Hyperbaric oxygen therapy in free flap surgery: is it meaningful?

Vishwanath, G

doi:10.1016/s0377-1237(11)60052-x

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…A total of 29 studies using HBOT for skin wound healing were included . Fourteen studies investigated HBOT for chronic wounds, 12 studies investigated HBOT in acute wounds, one study investigated HBOT in both chronic and acute wounds and two studies were performed in experimental wound models.…”

Section: Resultsmentioning

confidence: 99%

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Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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Oxygen is an important factor for wound healing. Although several different therapies investigated the use of oxygen to aid wound healing, the results of these studies are not unequivocal. This systematic review summarizes the clinical and experimental studies regarding different oxygen therapies for promoting wound healing, and evaluates the outcomes according the methodological details. A systematic literature search was conducted using Embase, Medline, Web of Science, Cochrane, PubMed publisher, and Google Scholar libraries. Clinical and experimental studies investigating oxygen for wound healing were selected. Included articles were categorized according to the kind of therapy, study design, and wound type. The methodological details were extracted and analyzed. Sixty-five articles were identified and divided in three different oxygen therapies: Local oxygen therapy, hyperbaric oxygen therapy, and supplemental inspired oxygen therapy. More than half of the included local oxygen and hyperbaric oxygen studies had one or more significant positive outcomes, 77 and 63%, respectively. Supplemental inspired oxygen therapy during gastrointestinal and vascular surgery was more likely to have a positive result than during other surgical interventions reducing surgical site infections. These many positive outcomes promote the use of oxygen treatment in the stimulation of wound healing. However, the lack of clinical studies and vast methodological diversity made it impossible to perform a proper comparison within and between the different therapies. Further randomized clinical studies are warranted to examine the value of these therapies, especially studies that investigate the more patient-friendly oxygen dressings and topical wound oxygen therapies. Also, to achieve more solid and consistent data, studies should use more standardized methods and subjects.

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Section: Resultsmentioning

confidence: 99%

“…Vishwanath investigated the effects of HBOT on free flaps. 56 Flap survival, flap edema, venous congestion, and period of postoperative recovery were evaluated. None of these findings were significantly different.…”

Section: Randomized Controlled Trialsmentioning

confidence: 99%

Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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show abstract

“…Incluyeron 8 estudios, involucrando pacientes con quemaduras agudas 44,45 , heridas por trauma 46 , quemaduras por radiación ultravioleta 47 , colgajos libres 48 , injertos de piel parcial 42 y postoperados de lifting facial 49 y reducción mamaria post radioterapia 50 . Siete de los 8 estudios favorecieron el uso de la cámara hiperbárica.…”

Section: Evidencia De Ensayos Clínicosunclassified

Uso de oxígeno hiperbárico para el manejo de heridas: bases físicas, biológicas y evidencia disponible

et al. 2014

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“…The operative technique requires involves vascular anastomosis and requires special instrumentation, Operative magnification, and training. 4,5 Antithrombotic agents such as low molecular-weight dextran, aspirin and heparin have been thought to play a significant role in this success. Ninety-six percent of micro surgeons use antithrombotic agents such as dextran, heparin and aspirin alone or combination in free flap transfer and replantation.…”

Section: Introductionmentioning

confidence: 99%

“…An increasing number of reports of significant morbidity and mortality related to these agents have brought into question their routine use in microsurgery. 3,4 Their adverse effects can cause morbidity and mortality in patients; with serious side effects from low-molecularweight dextran have been reported. For example, Disa and colleagues reported that dextran did not improve benefit in free flap survival but increased the risk of systemic complications.…”

Section: Introductionmentioning

confidence: 99%