Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

Oliai, Caspian; Fisher, Brandon J.; Jani, Ashish; Wong, Michael L.; Poli, Jaganmohan; Brady, Luther W.; Komarnicky, Lydia

doi:10.1016/j.ijrobp.2011.12.056

Cited by 69 publications

(68 citation statements)

References 16 publications

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“…However, HBOT does have numerous side-effects, including: claustrophobia, ear pain due to high atmospheric pressure, rare oxygen toxicity (seizures and alveolar membrane damage), and digitalis toxicity (digoxin or digitoxin). HBOT is a time-consuming treatment with variable reported response rates (27–92%) and relatively high recurrence rates (8–63%) [22, 23]. HBOT is not recommended during pregnancy and for patients with a fever of which the cause is unknown.…”

Section: Hyperbaric Oxygenmentioning

confidence: 99%

Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies

et al. 2018

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Section: Hyperbaric Oxygenmentioning

confidence: 99%

Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies

et al. 2018

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“…Nonetheless, many prospective studies [64][65][66] and retrospective studies [63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78] have been performed, and the results are presented in Table 3. Results are consistent and show a generally good response rate (80 %) especially in case of a short delay between the onset of bleeding and the initiation of HBO therapy (B6 months) [70,75].…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

A Practical Approach to the Management of Radiation-Induced Hemorrhagic Cystitis

Liem

Saad

Delouya

2015

Drugs

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Radiation-induced hemorrhagic cystitis (HC) is a complication of pelvic radiotherapy, mainly for prostate and uterine cancers. In the acute phase, patients feel urinary urgency and bladder pain. This phase is reversible after radiotherapy. In the chronic stage, an irritative syndrome is coupled with hematuria during the 2-10 years following radiotherapy. Cystoscopy shows white and frosted mucosa with telangiectasia. The incidence is estimated at 5 % or less. It is suggested that the radiation oncologist reviews the dosimetry plan to validate that the lesions coincide with significant radiation exposure confirming diagnosis of radiation-induced HC. The treatment for HC is first symptomatic, with bladder lavage, clot evacuation, coagulation via cystoscopy and blood transfusions if necessary. Subsequently, hyaluronic acid bladder instillation can be done with little toxicity. Hyperbaric oxygen therapy delivers pure oxygen to patients in a pressurized cabin, promoting angio-neogenesis and lowering hypoxia to the irradiated tissues. The clinical response rate is estimated to be around 80 %. Nevertheless, this approach is limited by the low availability, and length of treatment. While surgery remains an effective treatment for HC, it is the last option because of the high morbidity and mortality risks. Prospective studies need to be conducted to identify and evaluate new interventions, particularly for HC.

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“…Thereafter, a variety of therapeutic options are available if the hematuria is persistent. 1,3,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Following is a discussion of some of these alternatives. A small proportion of patients with HRC has severe, refractory, life-threatening hematuria and may require urinary diversion alone or combined with cystectomy.…”

Section: Managementmentioning

confidence: 99%

Hemorrhagic Radiation Cystitis

Mendenhall

Henderson

Costa

et al. 2015

American Journal of Clinical Oncology

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The optimal management of persistent hemorrhagic radiation cystitis is ill-defined. Various options are available and include oral agents (ie, sodium pentosan polysulfate), intravenous drugs (ie, WF10), topical agents (ie, formalin), hyperbaric oxygen, and endoscopic procedures (ie, electrical cautery, argon plasma coagulation, laser coagulation). In general, it is best to manage patients conservatively and intervene only when necessary with the option least likely to exacerbate the cystitis. More aggressive measures should be employed only when more conservative approaches fail. Bladder biopsies should be avoided, unless findings suggest a bladder tumor, because they may precipitate a complication.

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Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

Cited by 69 publications

References 16 publications

Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies

Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies

A Practical Approach to the Management of Radiation-Induced Hemorrhagic Cystitis

Hemorrhagic Radiation Cystitis

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