“…A number of investigators have studied HBOT in this setting. 47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64 An advantage of HBOT in these patients is the absence of the adverse effects on bladder structure or function that may be seen with other therapies, such as formalin or silver nitrate instillations, while avoiding the need for surgery. HBOT is also very well tolerated, with few adverse effects-the most common being pressure-related in the form of ear and sinus barotrauma.…”