Hyperbaric oxygen therapy for peripheral nerve damage induced in rabbits with clioquinol

Mukoyama, Masakuni; Iida, Mitsuo; Sobue, I

doi:10.1016/0014-4886(75)90070-9

Cited by 19 publications

(22 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Energy wise, climbing back up from the “metabolic well” mandates energy input. As discussed above, HBOT has been shown to induce neuroplasticity and reactivation of cells in chronic metabolic dysfunction in different type of brain injuries, and in FMS specifically ( Mukoyama et al, 1975 ; Bradshaw et al, 1996 ; Haapaniemi et al, 1998 ; Yildiz et al, 2004 ; Vilela et al, 2008 ; Yang et al, 2008 ; Chang et al, 2009 ; Boussi-Gross et al, 2013 , 2015 ; Efrati et al, 2013 ; Mu et al, 2013 ; Efrati and Ben-Jacob, 2014 ; Hadanny and Efrati, 2015 , 2016 ; Hadanny et al, 2015 ; Tal et al, 2015 ). HBOT supplies extra oxygen to the anaerobic brain regions, providing them with the energy needed to exit metabolic well.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperbaric oxygen therapy (HBOT), the application of hyperbaric pressure in conjunction with increased oxygen content, has been shown in several clinical studies to have the capacity to induce neuroplasticity in injured brains even years after an acute insult ( Boussi-Gross et al, 2013 , 2015 ; Efrati et al, 2013 ; Efrati and Ben-Jacob, 2014 ; Hadanny et al, 2015 ; Tal et al, 2015 ; Hadanny and Efrati, 2016 ). As demonstrated in different animal models, HBOT induces neuroplasticity by stimulating cell proliferation ( Mu et al, 2013 ), promotes neurogenesis of endogenous neural stem cells ( Yang et al, 2008 ), regenerates axonal white matter ( Chang et al, 2009 ), improves maturation and myelination of injured peripheral and cranial neural fibers ( Haapaniemi et al, 1998 ; Vilela et al, 2008 ), induces brain angiogenesis ( Tal et al, 2015 ), and stimulates axonal growth ( Mukoyama et al, 1975 ; Bradshaw et al, 1996 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen – Case Series Presentation and Suggested Bio-Psycho-Social Mechanism

et al. 2018

View full text Add to dashboard Cite

Fibromyalgia Syndrome (FMS) is a condition considered to represent a prototype of central sensitization syndrome, characterized by chronic widespread pain and along with symptoms of fatigue, non-restorative sleep and cognitive difficulties. FMS can be induced by trauma, infection or emotional stress with cumulative evidence that dissociation is relatively frequent in FMS patients. Two randomized controlled trials have shown that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity and be effective in patients suffering from FMS. In this paper we present, for the first time, case series of female fibromyalgia patients who, in the course of HBOT, suddenly recalled repressed traumatic memories of childhood sexual abuse (CSA). The surfacing of the repressed (dissociative) memories decades after the sexual abuse events was sudden and utterly surprising. No psychological intervention was involved. As the memories surfaced, the physical pain related to FMS subsided. In one patient who had brain single photon emission CT (SPECT) before and after HBOT, the prefrontal cortex appeared suppressed before and reactivated after. The 3 cases reported in this article are representative of a total of nine fibromyalgia patients who experienced a retrieval of repressed memory during HBOT. These cases provide insights on dissociative amnesia and suggested mechanism hypothesis that is further discussed in the article. Obviously, prospective studies cannot be planned since patients are not aware of their repressed memories. However, it is very important to keep in mind the possibility of surfacing memories when treating fibromyalgia patients with HBOT or other interventions capable of awakening dormant brain regions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen – Case Series Presentation and Suggested Bio-Psycho-Social Mechanism

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The elevated oxygen concentration in the blood and injured tissue during treatment (Calvert, Cahill, & Zhang, 2007;Niklas, Brock, Schober, Schulz, & Schneider, 2004;Reinert et al, 2003) helps supply the energy needed to regenerate damaged brain tissue. It has been shown that HBOT induced neuroplasticity is mediated by stimulating cell proliferation (Mu et al, 2013), neurogenesis of endogenous neural stem cells (Yang et al, 2008), regeneration of axonal white matter (Chang et al, 2009), improved maturation and myelination of injured neural fibers (Haapaniemi, Nylander, Kanje, & Dahlin, 1998;Vilela, Lazarini, & Da Silva, 2008), and stimulation of axonal growth, thus increasing the ability of neurons to function and communicate with each other (Bradshaw, Nelson, Fanton, Yates, & Kagan-Hallet, 1996;Mukoyama, Iida, & Sobue, 1975). A retrospective analysis of post-stroke patients in the late chronic stage revealed that HBOT can significantly improve the memory domain (Boussi-Gross et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis

Hadanny

Rittblat

Bitterman

et al. 2020

RNN

View full text Add to dashboard Cite

Background: Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage. Objective: The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chronic stage. The nature, type and location of the stroke were investigated as possible modifiers. Methods: A retrospective analysis was conducted on patients who were treated with HBOT for chronic stroke (>3 months) between 2008-2018. Participants were treated in a multi-place hyperbaric chamber with the following protocols: 40 to 60 daily sessions, 5 days per week, each session included 90 min of 100% oxygen at 2 ATA with 5 min air brakes every 20 minutes. Clinically significant improvements (CSI) were defined as > 0.5 standard deviation (SD). Results: The study included 162 patients (75.3% males) with a mean age of 60.75 ± 12.91. Of them, 77(47.53%) had cortical strokes, 87(53.7%) strokes were located in the left hemisphere and 121 suffered ischemic strokes (74.6%). HBOT induced a significant increase in all the cognitive function domains (p < 0.05), with 86% of the stroke victims achieving CSI. There were no significant differences post-HBOT of cortical strokes compared to sub-cortical strokes (p > 0.05). Hemorrhagic strokes had a significantly higher improvement in information processing speed post-HBOT (p < 0.05). Left hemisphere strokes had a higher increase in the motor domain (p < 0.05). In all cognitive domains, the baseline cognitive function was a significant predictor of CSI (p < 0.05), while stroke type, location and side were not significant predictors. Conclusions: HBOT induces significant improvements in all cognitive domains even in the late chronic stage. The selection of post-stroke patients for HBOT should be based on functional analysis and baseline cognitive scores rather than the stroke type, location or side of lesion.

show abstract

“…HBOT induces neuroplasticity by stimulating cell proliferation [139], promotes neurogenesis of endogenous neural stem cells [140], regenerates axonal white matter [141], improves maturation and myelination of injured peripheral and cranial neural fibers [142,143], and stimulates axonal growth thus increasing the ability of neurons to function and communicate with each other [144,145]. The common denominator to all repair and regeneration mechanisms is that they are all oxygen-dependent.…”

Section: Hyperbaric Oxygen Therapy (Hbot)mentioning

confidence: 99%

Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions

Hadanny

Efrati

2016

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

Persistent post-concussion syndrome caused by mild traumatic brain injury has become a major cause of morbidity and poor quality of life. Unlike the acute care of concussion, there is no consensus for treatment of chronic symptoms. Moreover, most of the pharmacologic and non-pharmacologic treatments have failed to demonstrate significant efficacy on both the clinical symptoms as well as the pathophysiologic cascade responsible for the permanent brain injury. This article reviews the pathophysiology of PCS, the diagnostic tools and criteria, the current available treatments including pharmacotherapy and different cognitive rehabilitation programs, and promising new treatment directions. A most promising new direction is the use of hyperbaric oxygen therapy, which targets the basic pathological processes responsible for post-concussion symptoms; it is discussed here in depth.

show abstract

Hyperbaric oxygen therapy for peripheral nerve damage induced in rabbits with clioquinol

Cited by 19 publications

References 5 publications

Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen – Case Series Presentation and Suggested Bio-Psycho-Social Mechanism

Recovery of Repressed Memories in Fibromyalgia Patients Treated With Hyperbaric Oxygen – Case Series Presentation and Suggested Bio-Psycho-Social Mechanism

Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis

Treatment of persistent post-concussion syndrome due to mild traumatic brain injury: current status and future directions

Contact Info

Product

Resources

About