Hyperbaric oxygen therapy for hemorrhagic radiation cystitis

Lin, Kung-Hung; Lee, Hui-Chieh; Huang, Wen‐Yen; Huang, Po‐Wei; Ke, Seng-Chung; Lee, Man-Gang

doi:10.4103/fjs.fjs_19_17

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…The widest body of evidence in the use of HBO2 for HC in the recipients of allogeneic stem cell transplant is found when radiation is the etiological trigger . Multiple case reports and series are now noted in the pediatric population as well as middle‐aged and geriatric populations on use of HBO2 as a treatment for cyclophosphamide, or viral infection–related HC .…”

Section: Discussionmentioning

confidence: 99%

“…The widest body of evidence in the use of HBO2 for HC in the recipients of allogeneic stem cell transplant is found when radiation is the etiological trigger. [14][15][16][17] Multiple case reports and series are now noted in the pediatric population 7,18 as well as middle-aged 13 and geriatric populations 19,20 on use of HBO2 as a treatment for cyclophosphamide, 21 or viral infection-related HC. 22 Reports as old as 1985 23 can be found with evidence of efficacy of this treatment at many centers throughout the world 18,24,25 as a therapeutic option for refractory HC.…”

Section: Discussionmentioning

confidence: 99%

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Hyperbaric oxygen as a treatment modality in cyclophosphamide‐induced hemorrhagic cystitis

Kaur

Khan

Rodriguez

et al. 2018

Pediatric Transplantation

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Late-onset HC is a well-recognized complication associated with cyclophosphamide/acrolein-induced toxicity. It poses a management challenge when hyperhydration and bladder irrigation do not result in clinical improvement as desired. The data regarding use of hyperbaric oxygen therapy (HBO2) as an early treatment modality in this clinical setting are limited. We present 2 cases, that were refractory to hyperhydration and bladder irrigation but responded to HBO2. They were treated with 20-30 daily sessions over weekdays with 100% oxygen for 90 minutes at 2 atmospheric pressure units (2 atm). Both patients reported improved symptoms within the first 15 sessions, and hematuria diminished by 20 sessions. Hyperbaric oxygen is a less invasive, outpatient therapy that is effective for treatment of HC and is tolerated well by young patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen as a treatment modality in cyclophosphamide‐induced hemorrhagic cystitis

Kaur

Khan

Rodriguez

et al. 2018

Pediatric Transplantation

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“…in 1985 . To date, several case series of HBO therapy for RHC have been reported, with a 60–100% efficacy for complete hematuria response (Table ) . Although there is no consensus on HBO treatment regimens, the general dose is 2.0–3.0 ATA for 90 min, for approximately 30 sessions.…”

Section: Radiation‐induced Hemorrhagic Cystitismentioning

confidence: 99%

Potential of hyperbaric oxygen in urological diseases

et al. 2019

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Abbreviations & Acronyms AKI = acute kidney injury Alum = aluminium potassium sulfate ATA = atmosphere absolute CR = complete response CRPC = castration-resistant prostate cancer DC = dystrophic calcification EMT = epithelial-tomesenchymal transition FG = Fournier gangrene FGSI = Fournier Gangrene Severity Index HA = hyaluronic acid HBO = hyperbaric oxygen HIC = Hunner type interstitial cystitis IC/PBS = interstitial cystitis/painful bladder syndrome NHIC = non-Hunner type interstitial cystitis PR = partial response RHC = radiation-induced hemorrhagic cystitis ROS = reactive oxygen species RT = radiation therapy TRP = transient receptor potential channel WF10 = immunokine Correspondence: TomoakiAbstract: Hyperbaric oxygen therapy is a promising medical technology that delivers oxygen to targeted tissues at high pressure to increase the amount of dissolved oxygen in the blood. Over the past three decades, hyperbaric oxygen has been used in a variety of conditions, including radiation-induced tissue injuries, non-healing states with ischemia and malignant neoplasms. In the field of urology, hyperbaric oxygen has also been applied to some pathological conditions (e.g. radiation-induced hemorrhagic cystitis, Fournier gangrene, interstitial cystitis, male infertility, acute kidney injury and urological cancers). In normal and injured tissues, hyperoxia from hyperbaric oxygen therapy contributes to anti-inflammation, angiogenesis through endothelial proliferation, enhanced fibroblastic activity, increased lymphocyte and macrophage activity, and bactericidal effects with the aim of wound repair. In cancerous tissues, the enhanced supply of oxygen into the hypoxic cancer cells can exert inhibitory effects on factors that contribute to their aggressiveness (e.g. cell survival, escape from apoptosis, epithelial-to-mesenchymal transition and tumor immunotolerance), and sensitize the tumor to radiation therapy and chemotherapy. However, further research, including multicenter clinical studies, is essential for determining the role of hyperbaric oxygen therapy in refractory urological diseases that are resistant to conventional therapies.

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“…It has been shown that acute and non-complicated wounds need at least 2 mmHg oxygen tensions for healing. Chronic and complicated skin wounds generally undergo hypoxia, which results in delayed healing process, increased amount of wound necrotic tissue and impaired ability to combat microbial contamination [39,40]. Besides the requirements of wound microenvironment (nutrition, oxygenation, vascularization), other external factors must be considered during the healing of chronic wounds, including moisture, temperature and pressure [41].…”

Section: Wound Healing Processmentioning

confidence: 99%

The importance of oxygen release in diabetic foot ulcer wounds

2019

Bioengineering Int

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Oxygen is the essential element required for proper physiological function of cells, tissues and organs within healthy human body. Thanks to its intricate structure, the skin provides a multiprotective barrier against traumatic and non-traumatic injuries, but also a complex and successful self-healing process of the affected tissue. In the particular case of chronic skin wounds, such as diabetic foot ulcer wounds, there is an immediate demand to develop alternative procedures that prevent infection, speed up healing and eliminate any disrupting factor that may interfere with the therapeutic process. Given the importance of oxygen during wound healing cascade, impressive attention was oriented towards the fabrication of oxygen-releasing wound dressings.

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Hyperbaric oxygen therapy for hemorrhagic radiation cystitis

Cited by 8 publications

References 13 publications

Hyperbaric oxygen as a treatment modality in cyclophosphamide‐induced hemorrhagic cystitis

Hyperbaric oxygen as a treatment modality in cyclophosphamide‐induced hemorrhagic cystitis

Potential of hyperbaric oxygen in urological diseases

The importance of oxygen release in diabetic foot ulcer wounds

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