Hyperbaric Oxygen Therapy: Descriptive Review of the Technology and Current Application in Chronic Wounds

Hajhosseini, Babak; Kuehlmann, Britta; Bonham, Clark A.; Kamperman, Kathryn J; Gurtner, Geoffrey C.

doi:10.1097/gox.0000000000003136

Cited by 34 publications

(19 citation statements)

References 58 publications

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“…HBOT is recognized as an effective treatment for replacing any form of oxygen deficiency [ 14 ]. HBOT is a non-invasive treatment and serves as primary or adjunctive therapy in various medical conditions [ 16 ]. The efficacy of HBOT has been documented in several systemic illnesses, such as arterial gas embolism, carbon monoxide poisoning, decompression sickness, crush injuries, and diabetic foot ulcer [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review

et al. 2021

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Background Oxygenation serves as a cornerstone in the treatment of COVID-19, and several methods have been extensively studied so far. Herein, we aimed to systematically review the studies discussing hyperbaric oxygen therapy (HBOT) to examine its reported efficacy and adverse events in patients with COVID-19. Methods We systematically searched and retrieved the relevant articles using keywords on the online databases, including PubMed, Scopus, Embase, Web of Science, and Cochrane databases up to April 11th, 2021. The retrieved records underwent a two-step title/abstract and full-text screening process, and the eligible papers were identified. National Institutes of health (NIH) quality assessment tool was used for this study. This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) with ID CRD42021269821. Results Eight articles from three countries were included. All the included studies had good and fair quality scores, with no poor studies included in this systematic review (Good: n = 5, Fair: n = 3). Studies were divided into clinical trials and case reports/series. Most of the studies used HBOT less than 1.5–2 absolute atmospheres (ATA) for 90 min sessions and thereafter sessions were decreased to 60 min. Trials demonstrated most of the patients recovered after receiving HBOT, and blood oxygen saturation increased after several sessions of HBOT. Conclusion Overall, HBOT seems to be a safe and effective oxygenation method in patients with COVID-19. However, there is limited knowledge and evidence regarding the effects and mechanism of HBOT in COVID-19 treatment, and further evaluations require extensive well-designed studies.

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Section: Introductionmentioning

confidence: 99%

The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review

et al. 2021

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“…Hyperbaric oxygen (HBO) therapy is directly relevant to lower-extremity disease. Among these include clostridial myonecrosis, acute traumatic ischemia, better wound healing, necrotizing soft tissue infections, refractory osteomyelitis, damaged skin grafts and flaps, and thermal burns 72 . The delivery of 100% oxygen in a chamber via separate double-blinded pipes at 2.5 atmospheres absolute increases oxygenation, neovascularization, and the wound’s antimicrobial effect 73 .…”

Section: Therapeutic Strategies For Diabetic Wound Healingmentioning

confidence: 99%

Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic Wound Healing – an Overview

et al. 2022

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Diabetic wound healing is a complicated procedure because hyperglycemia changes the various stages of wound healing. In type 2 diabetes mellitus (T2DM), oxidative stress is proven to be a critical factor in causing non-healing wounds and aggravating the inflammatory phase, resulting in the amputation of lower limbs in T2DM patients. This makes scientists figure out how to control oxidative stress and chronic inflammation at the molecular level. Nuclear factor erythroid 2- related factor 2 (Nrf2) releases antioxidant proteins to suppress reactive oxygen species (ROS) activation and inflammation. The current review discusses the role of Nrf2 in improving diabetic wound healing by reducing the production of ROS and thus reducing oxidative stress, as well as inhibiting nuclear factor kappa B (NF-kB) dissociation and nuclear translocation, which prevents the release of inflammatory mediators and increases antioxidant protein levels, thereby improving diabetic wound healing. As a result, the researcher will be able to find a more effective diabetic wound healing therapy.

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“…Hyperbaric oxygen therapy (HBOT) has many physiologic effects that could promote tissue repair, and reports of its efficacy in wound healing date back to the 1950s 47 . HBOT has multiple approved indications and is used for the treatment of carbon monoxide poisoning, decompression sickness, and gas embolism.…”

Section: Wound Treatmentmentioning

confidence: 99%

Clinical approach to chronic wound management in older adults

Alam

Hasson

Reed

2021

J American Geriatrics Society

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Older adults are at high risk of developing chronic wounds due to numerous changes that occur with aging. It is reasonable to consider chronic wounds as a geriatric syndrome—highly prevalent, multifactorial, and associated with substantial morbidity and mortality. Due to the morbidity and cost associated with chronic wounds, prevention, early diagnosis, and treatment are important. The most common chronic wounds presenting in older adults are pressure and vascular wounds, including those associated with diabetes. Atypical wounds are also common and should raise the suspicion for skin malignancy. Diagnosis is primarily clinical and assessment should include documentation of wound characteristics, such as location, size and depth, presence of slough, drainage, odor, and infection. The mainstay of treatment is based on the TIME principle: Tissue debridement, Infection control, Moisture balance, and optimal wound Edges. The use of protein supplements has been shown to improve wound healing in subsets of older adults. In addition to wound care and optimizing nutrition, disease‐specific wound therapy forms an integral part of wound management. Pressure reduction for pressure injury, compression therapy for venous wounds, evaluation of arterial circulation with ABI or arterial Doppler and iCC for diabetic ulcers form the mainstays of therapy. Atypical wounds may present as chronic ulcers and should be biopsied. The goals of treatment should be realistic and for some older adults, palliative wound management may be more appropriate.

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Hyperbaric Oxygen Therapy: Descriptive Review of the Technology and Current Application in Chronic Wounds

Cited by 34 publications

References 58 publications

The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review

The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review

Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic Wound Healing – an Overview

Clinical approach to chronic wound management in older adults

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