Hyperbaric oxygen therapy as an anti-infective agent

Çimşit, Maide; Uzun, Günalp; Yıldız, Şenol

doi:10.1586/eri.09.76

Cited by 84 publications

(44 citation statements)

References 72 publications

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“…18 Furthermore, HBO seems to be beneficial in osteomyelitis and soft tissue infections. 7,24 These advantageous effects of HBO are attributable to the intracellular generation of reactive oxygen species and nitric oxide, both playing a central role in cell signal transduction cascades. [26][27][28][29] Based on these beneficial effects, HBO therapy has been used for the treatment of various conditions.…”

Section: Diabetic Footmentioning

confidence: 99%

The Role of Hyperbaric Oxygen in the Treatment of Diabetic Foot Ulcers

et al. 2011

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Diabetic foot ulcers are still extremely difficult to heal. Therefore, therapeutic options to improve healing rates are continuously being explored. Hyperbaric oxygen (HBO) has been used in addition to standard treatment of the diabetic foot for more than 20 years. Evidence suggests that HBO reduces amputation rates and increases the likelihood of healing in infected diabetic foot ulcers, in association with improved tissue oxygenation, resulting in better quality of life. Nonetheless, HBO represents an expensive modality, which is only available in few centers. Moreover, adverse events necessitate a closer investigation of its safety. Finally, it is not entirely clear which patients stand to benefit from HBO and how these should be selected. In conclusion, HBO appears promising, but more experience is needed before its broad implementation in the routine care of the diabetic foot.

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Section: Diabetic Footmentioning

confidence: 99%

The Role of Hyperbaric Oxygen in the Treatment of Diabetic Foot Ulcers

et al. 2011

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“…Turhan [20] and others [32-34] associated the bacteriostatic and bactericidal effects of HBO to hyperoxic toxicity which leads to increased production of oxygen radicals such as superoxide (O 2 - ), hydrogen peroxide (H 2 O 2 ) and hydroxyl radical (.OH) at a rate in excess of the capacity of the cellular defense mechanisms to inactivate such species. Although a similar pathway, i.e., the production of reactive oxygen species, has been suggested as the mechanism underlying the bactericidal effect of blue light [35-36], ongoing works in our laboratory suggest that another mechanism may be at play, i.e., that 470 nm light alters MRSA membrane potential.…”

Section: Discussionmentioning

confidence: 99%

The bactericidal effect of 470-nm light and hyperbaric oxygen on methicillin-resistant Staphylococcus aureus (MRSA)

et al. 2015

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It has been shown that, in vitro, hyperbaric oxygen (HBO) suppresses 28% bacterial growth, while 470 nm blue light alone suppresses up to 92% methicillin resistant Staphylococcus aureus (MRSA) in one application in vitro. Therefore, we determined if combined 470 nm light (55 J/cm2) and HBO will yield 100% bacterial suppression in experimental simulation of mild, moderate or severe MRSA infection. We cultured MRSA at 3×106, 5×106, 7×106, 8×106 or 12×106 CFU/ml and treated each concentration in four groups as follows: (1) Control (no treatment) (2) photo-irradiation only, (3) photo-irradiation then HBO, (4) HBO only, and (5) HBO then photo-irradiation. Bacteria colonies were then quantified. The results showed that at each bacterial concentration, HBO alone was significantly less effective in suppressing MRSA than photo-irradiation or combined HBO and photo-irradiation (p<0.0001). Similarly, at no bacterial concentration did combined HBO and 470 nm light treatment yield a statistically better result than 470 nm light alone (p > 0.05), neither did HBO treatment either before or after irradiation make a difference. Furthermore, at no bacterial concentration was 100% MRSA suppression achieved. Indeed, the maximum bacterial suppression attained was in the mild infection model (3×106 CFU/ml), with blue light producing 97.3±0.2% suppression and HBO +55 J/cm2 yielding 97.5±2.5% suppression. We conclude that: (1) HBO and 470 nm light individually suppress MRSA growth; (2) 470nm blue light is more effective in suppressing MRSA than HBO; and (3) HBO did not act synergistically to heighten the bactericidal effect of 470 nm light.

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“…Studies on NF advocate a treatment protocol of at least ten sessions. 15 Patient #2 was early suspected with an anaerobic infection. HBOT was considered at first, but not started as Clostridium ssp.…”

Section: Discussionmentioning

confidence: 99%

“…HBOT provides oxygenation to otherwise ischemic areas, and reduces the impact of hypoxia on leukocyte function. 13,15,17 The oxygenation of tissue thereby limits the spread and progression of infection. HBOT of infections also occurs via HBO acting as a bactericide or as a bacteristatic agent to some microorganisms, and through an additive and/or synergistic effect on some antimicrobial drugs.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Treatment in Three Cases of Necrotizing Infection of the Neck

Nedrebø

Bruun

Skjåstad

et al. 2012

Infectious Disease Reports

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Necrotizing infections of the head and neck are rare conditions in our hospital. Clinical and microbiological characteristics of three consecutive cases treated in Haukeland University Hospital in western Norway in the year 2010 are described. Two cases of Lemierre's syndrome and one case with a descending necrotizing mediastinitis (DNM) were diagnosed. All three cases were treated with broad spectrum antibiotics and in two cases surgery was possible. Hyperbaric oxygen treatment (HBOT) with intensive care facilities became recently available at our hospital, and this treatment was used in all these patients regardless of surgery. In one case we describe the use of HBOT on the basis of strong clinical suspicion of anaerobic infection only. Bacterial identification by partial sequencing of the 16SrDNA gene proved to be a useful supplement to conventional culture techniques. All the cases all demonstrated a significant clinical improvement after introduction of HBOT. When HBOT is available, it should be considered as adjunctive treatment in extensive infections with anaerobes.

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Hyperbaric oxygen therapy as an anti-infective agent

Cited by 84 publications

References 72 publications

The Role of Hyperbaric Oxygen in the Treatment of Diabetic Foot Ulcers

The Role of Hyperbaric Oxygen in the Treatment of Diabetic Foot Ulcers

The bactericidal effect of 470-nm light and hyperbaric oxygen on methicillin-resistant Staphylococcus aureus (MRSA)

Hyperbaric Oxygen Treatment in Three Cases of Necrotizing Infection of the Neck

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