Hyperbaric oxygen preconditioning induces tolerance against brain ischemia–reperfusion injury by upregulation of antioxidant enzymes in rats

Li, Jiasi; Liu, Wenwu; Ding, Shilei; Xu, Wei; Guan, Yangtai; Zhang, Junyi; Sun, Xuejun

doi:10.1016/j.brainres.2008.03.007

Cited by 109 publications

(66 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HBOT therapy before and after I-R was associated with a significant decrease in the expression of caspase-3, concomitant with decreased cellular damage, as detected in the histological evaluation (grade 2). In accordance with our findings preconditioning with HBOT has previously been shown to increase survival and suppress activity of caspase-3 and caspase-9 22 . There is a relationship between the effect of HBOT on I-R injury in the bowels and apoptotic injury in the mucosa 22 .…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury

Daniel¹,

Cardoso

Gois³

et al. 2011

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE: Adequate tissue oxygenation is essential for healing. Hyperbaric oxygen therapy (HBOT) has potential clinical applications to treat ischemic pathologies, however the exact nature of any protective effects are unclear at present. We therefore investigated the potential role of HBOT in modulating the ischemia/reperfusion (I/R) injury response in intestinal model of I/R injury. METHODS: Male Wistar rats were subjected to surgery for the induction of intestinal ischemia followed by reperfusion. HBOT was provided before and/or after intestinal ischemia. Cell viability in the intestinal tissue was assessed using the MTT assay and by measuring serum malondealdehyde (MDA). Microvascular density and apoptosis were evaluated by immunohistochemistry. RESULTS:The results indicate that HBOT treatment pre-and post-ischemia reduces lesion size to the intestinal tissue. This treatment increases cell viability and reduces the activation of caspase-3, which is associated with increased number of tissue CD34 cells and enhanced VEGF expression. CONCLUSION: The hyperbaric oxygen therapy can limit tissue damage due to ischemia/reperfusion injury, by inducing reparative signaling pathways. Keywords: Reperfusion Injury. Hyperbaric Oxygenation. Rats. RESUMO OBJETIVO:Oxigenação tissular adequada é essencial para cicatrização. Oxigenoterapia hiperbárica (HBOT) tem aplicação clínica para tratar lesões isquêmicas, entretanto a natureza exata dos mecanismos envolvidos permanece incerta. Procuramos investigar o papel potencial da HBOT na modulação da resposta a uma lesão por isquemia reperfusão (I/R) intestinal em modelo de lesão de I/R. MÉTODOS: Ratos machos Wistar foram submetidos à cirurgia para a indução da isquemia intestinal seguida de reperfusão. HBOT foi fornecido antes e / ou após a isquemia intestinal. A viabilidade das células no tecido intestinal foi avaliada através do ensaio de MTT e pela medição malondealdeido (MDA) no plasma. Densidade microvascular e apoptose foram avaliados por imuno-histoquímica. RESULTADOS: Os resultados indicam que o tratamento HBOT pré e pós-isquemia reduz o tamanho da lesão ao tecido intestinal. Este tratamento aumenta a viabilidade celular e reduz a ativação da caspase-3, que está associada com aumento do número de células CD 34 no tecido e da expressão da VEGF. CONCLUSÃO: A oxigenoterapia hiperbárica pode limitar os danos do tecido devido à lesão por isquemia/reperfusão, induzindo às vias de sinalização reparadora. Descritores: Traumatismo por Reperfusão. Oxigenação Hiperbárica. Ratos.Daniel RAF et al.

show abstract

Section: Discussionsupporting

confidence: 93%

“…In accordance with our findings preconditioning with HBOT has previously been shown to increase survival and suppress activity of caspase-3 and caspase-9 22 . There is a relationship between the effect of HBOT on I-R injury in the bowels and apoptotic injury in the mucosa 22 . Early treatment with…”

Section: Discussionsupporting

confidence: 93%

Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury

Daniel¹,

Cardoso

Gois³

et al. 2011

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Expression of these genes can provide insights into the metabolic state of the tissue under different physiological conditions (Hooper and Hooper 2009;Hooper et al 2014). Evidence that HBOT can condition tissues to promote function and survival comes from the study of rat models of myocardial infarction (Han et al 2008;Sun et al 2011) and cerebral ischemia reperfusion injury (Li et al 2008(Li et al , 2009Cheng et al 2011), as well as a mouse model of repeated UV-A skin exposure (Fuller et al 2013). Whether or not HBOT can be used therapeutically in selected patient populations to alleviate tissue damage arising from chronic inflammation and oxidative stress remains to be determined.…”

mentioning

confidence: 99%

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Verma

Chopra

Giardina

et al. 2015

Cell Stress and Chaperones

View full text Add to dashboard Cite

The disease burden from diabetic kidney disease is large and growing. Effective therapies are lacking, despite an urgent need. Hyperbaric oxygen therapy (HBOT) activates Nrf2 and cellular antioxidant defenses; therefore, it may be generally useful for treating conditions that feature chronic oxidative tissue damage. Herein, we determined how periodic exposure to oxygen at elevated pressure affected type 2 diabetes mellitus-related changes in the kidneys of db/db mice. Two groups of db/db mice, designated 2.4 ATA and 1.5 ATA, were treated four times per week with 100 % oxygen at either 1.5 or 2.4 ATA (atmospheres absolute) followed by tests to assess kidney damage and function. The sham group of db/db mice and the Hets group of db/+ mice were handled but did not receive HBOT. Several markers of kidney damage were reduced significantly in the HBOT groups including urinary biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CyC) along with significantly lower levels of caspase-3 activity in kidney tissue extracts. Other stress biomarkers also showed trends to improvement in the HBOT groups, including urinary albumin levels. Expressions of the stress response genes NRF2, HMOX1, MT1, and HSPA1A were reduced in the HBOT groups at the end of the experiment, consistent with reduced kidney damage in treated mice. Urinary albumin/creatinine ratio (ACR), a measure of albuminuria, was significantly reduced in the db/db mice receiving HBOT. All of the db/db mouse groups had qualitatively similar changes in renal histopathology. Glycogenated nuclei, not previously reported in db/db mice, were observed in these three experimental groups but not in the control group of nondiabetic mice. Overall, our findings are consistent with therapeutic HBOT alleviating stress and damage in the diabetic kidney through cytoprotective responses. These findings support an emerging paradigm in which tissue oxygenation and cellular defenses effectively limit damage from chronic oxidative stress more effectively than chemical antioxidants.

show abstract

“…The hyperoxic state during HBO treatments causes primarily an increased production of the su peroxide radical (26) and, as a response, upregulation of the antioxidant enzyme SOD was reported for several times (34). Almost all of our previous one-session HBO exposure studies also resulted in increased SOD activities in rat erythrocytes (9,11,14).…”

Section: Discussionmentioning

confidence: 76%

Response of Rat Erythrocyte Oxidative Stress Markers to Repetitive Hyperbaric Oxygen Exposures Up to 40 Daily Sessions / Odgovor Markera Oksidativnog Stresa U Eritrocitima Pacova Na Višestruko Izlaganje Hiperbaričnom Kiseoniku Do 40 Seansi Dnevno

Şimşek¹,

Yıldırım²,

Demirbaş³

et al. 2013

Journal of Medical Biochemistry

View full text Add to dashboard Cite

SummaryBackground: Studies with single-session hyperbaric oxygen exposures have shown that HBO-induced oxidative stress is proportional to exposure pressure and duration. Since the efficacy of hyperbaric oxygen mainly depends on repetitive exposures, this study aimed to investigate the oxidative effect of hyperbaric oxygen administered for 5 to 40 sessions. Methods: Sixty rats were divided into one control and 6 study groups. Study groups were exposed to 5, 10, 15, 20, 30, and 40 daily consecutive 2.8 atm/90 min hyperbaric oxygen sessions. Animals were sacrificed 24 h after the last hyperbaric oxygen administration. Malondial dehyde and carbonylated protein levels as well as superoxide dismutase activities were determined in isolated rat erythrocytes. Results: Carbonylated protein levels increased significantly after just 5 hyperbaric oxygen exposures; reached a peak level with 10 exposures; were still significantly higher than controls after 15 sessions; and de creased to normal limits after 20 exposures. Malondial dehyde le vels were found to be significantly increased in the 10 to 30, but not in the 5 and 40-session groups. Superoxide dismutase activity showed elevated levels only in the 5 and 10 times hyperbarical oxygenexposed groups. Conclusions: The suppressed oxidative stress level after 40 exposures suggests an effective endogenous antioxidant defense in repetitive HBO administrations.

show abstract

Hyperbaric oxygen preconditioning induces tolerance against brain ischemia–reperfusion injury by upregulation of antioxidant enzymes in rats

Cited by 109 publications

References 17 publications

Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury

Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Response of Rat Erythrocyte Oxidative Stress Markers to Repetitive Hyperbaric Oxygen Exposures Up to 40 Daily Sessions / Odgovor Markera Oksidativnog Stresa U Eritrocitima Pacova Na Višestruko Izlaganje Hiperbaričnom Kiseoniku Do 40 Seansi Dnevno

Contact Info

Product

Resources

About