Hyperbaric oxygen preconditioning improves myocardial function, reduces length of intensive care stay, and limits complications post coronary artery bypass graft surgery

Yogaratnam, Jeysen; Laden, Gerard; Guvendik, Levent; Cowen, Mike; Cale, Alex; Griffin, Steve

doi:10.1016/j.carrev.2009.03.004

Cited by 50 publications

(39 citation statements)

References 43 publications

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“…It is also possible, however, to administer HBO to organs, if the preservation fluid is exposed to hyperbaric oxygen. A favourable impact on organs in heart transplantation was shown when using HBO [19][20][21][22]. However, to our knowledge, the influence of preoxygenation of preservation solutions on organ quality in pancreas preservation has not been determined yet.…”

Section: Introductionmentioning

confidence: 83%

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Hyperbaric oxygenation of UW solution positively impacts on the energy state of porcine pancreatic tissue*

et al. 2011

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Background: Pancreatic islet transplantation is a promising option for the treatment of diabetic patients; xenotransplantation of porcine islet cells would be a possibility to overcome the shortage of donor organs. Usually the donor pancreas is preserved with University of Wisconsin (UW) solution. A large number of reports have shown that the two-layer method (TLM), which employs oxygenated perfluorochemical and UW solution, is superior to simple cold storage. However, the extensive use of TLM is cost intensive and there is evidence that TLM only oxygenates small parts of the organ preserved. Another possibility to increase the oxygen supply during organ preservation would be the use of hyperbaric oxygenation (HBO) which increases the oxygen tension in fluids. The aim of this study was to evaluate the effect of pre-oxygenation of different preservation solutions on organ quality in terms of high energy phosphate levels as well as the occurrence of apoptosis and the induction of heat shock proteins and nitrosative stress induced cell death in porcine pancreatic tissue.Methods: Porcine pancreatic tissue was preserved in different preservation solutions with or without pre-oxygenation for 6 hours of cold ischemic time (CIT). Then, tissue specimens were harvested and high energy phosphate levels were determined by HPLC. Moreover, immunohistochemistry was performed in order to detect occurrence of apoptosis, heat shock protein 70 (HSP70) as well as nitrosative stress induced cell death.Results: Organs stored in pre-oxygenated UW solution showed best results in terms of high energy phosphate levels; apoptotic cells per islet as well as HSP70 positivity were significantly less when compared to simple UW storage and all other organ preservation solutions with or without pre-oxygenation.Conclusions: Pre-oxygenation of UW solution is a simple and promising method to improve islet cell quality after cold organ storage. However, further in vitro experiments have to be performed in order to confirm these findings.

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Section: Introductionmentioning

confidence: 83%

“…High energy phosphates (ATP, ADP, AMP and phosphocreatine for heart samples), hypoxanthine and xanthine were measured by HPLC as previously described[21][22][23]. In brief, separation was performed on a Hypersil ODS column (5 mm, 250Â4 mm I.D.)…”

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confidence: 99%

Hyperbaric oxygenation of UW solution positively impacts on the energy state of porcine pancreatic tissue*

et al. 2011

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“…HBO 2 is especially effective as a preconditioning method - alleviating cardiac ischemic injury in a rat model and improving heart function parameters (left ventricular systolic pressure and myocardial contractility indicators), as demonstrated in the work of Han et al [63]. In clinical studies, preconditioning patients with repeated HBO 2 prior to coronary artery bypass graft surgery induces myocardial and cerebral protection (smaller rise in troponin and S100 calcium binding protein B levels), improves myocardial function (left ventricular stroke work), reduces the length of intensive care stay (by 18%) and limits postoperative complications [67,68]. …”

Section: Hyperbaric Oxygen Use In Disorders With Vascular Damagementioning

confidence: 99%

“…Potential regulation of antioxidant systems by HBO 2 can be relevant for a number of diseases where oxidative stress plays an important role such as atherosclerosis, limb ischemia or reperfusion injury; this makes a better understanding of these mechanisms necessary. The beneficial effects of HBO 2 in myocardial ischemia and preconditioning with HBO 2 which limits myocardial damage could prove to be important [63,64,65,66,67,68]. …”

Section: Molecular Effects Of Hyperbaric Oxygen In Disorders and Expementioning

confidence: 99%

Restoring Vascular Function with Hyperbaric Oxygen Treatment: Recovery Mechanisms

Drenjančević-Perić

Kibel²

2013

J Vasc Res

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Treatment with hyperbaric oxygen can be a beneficial adjuvant therapy in various disorders characterized by compromised tissue oxygenation and perfusion. However, the effects of hyperbaric oxygenation cannot be simply explained as a compensation of the oxygen deficit. Hyperbaric oxigenation has a much broader influence and has the ability to alter protein expression, modulate signaling pathways and affect vascular structure and function. We discuss some of the most important uses of hyperbaric oxigenation for clinical conditions that involve abnormal vascular function. We present recent studies and insights into the mechanisms and effects of hyperbaric oxygen in the vasculature.

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“…20 In addition, Yogaratnam et al demonstrated that HBO preconditioning before coronary artery bypass graft surgery decreased myocardial damage, intraoperative blood loss, ICU length of stay, and postoperative complications. 21 Interestingly, in an experimental study, HBO therapy results in an otoprotection effect against Cisplatin-induced ototoxicity. 22 In a series of 89 liver transplant patients, donor hyperoxygenation before organ harvest, defined as a PaO 2 value greater than 150 mmHg, was associated with good graft outcome.…”

mentioning

confidence: 99%

Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

Saadat¹,

Maghani²,

Rahimi³

et al. 2013

Renal Failure

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Background: Cisplatin is a potent anticancer drug, but its nephrotoxicity limits the clinical use of it. To reduce the Cisplatin-induced nephrotoxicity, various interventions have been implicated. The aim of this study was to examine whether preconditioning with normobaric hyperoxia would prevent Cisplatin-induced nephrotoxicity in patient with solid tumor. Methods: In a prospective study, 80 adult patients with solid tumor who were treated with Cisplatin between February 2011 and December 2011 were included. Forty-three patients were exposed to pure oxygen via non-rebreathing reservoir mask which increased the provided oxygen rate to 60% oxygen for 2 hours at 48, 24, and 6 hours before intravenous administration of Cisplatin and 37 patients received only Cisplatin as a control group. Estimated glomerular filtration rate (eGFR) calculated in all patients on day 1 before and on days 1, 3, 6, 30 after Cisplatin exposures. Results: Patients treated with Cisplatin and 60% oxygen showed a mild improvement in eGFR and mild reduction of serum creatinine after 30 days with statistically mild significant differences (p ¼ 0.048). Conclusion: This study showed that normobaric and intermittent precondition of 60% oxygen prior to Cisplatin treatment had an acute transient adverse effect on renal function; however, the improvement of renal function will be seen after 30 days. Thus, it may help to prevent Cisplatin nephrotoxicity.

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Hyperbaric oxygen preconditioning improves myocardial function, reduces length of intensive care stay, and limits complications post coronary artery bypass graft surgery

Cited by 50 publications

References 43 publications

Hyperbaric oxygenation of UW solution positively impacts on the energy state of porcine pancreatic tissue*

Hyperbaric oxygenation of UW solution positively impacts on the energy state of porcine pancreatic tissue*

Restoring Vascular Function with Hyperbaric Oxygen Treatment: Recovery Mechanisms

Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

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