Hyperbaric Oxygen Preconditioning Alleviates Myocardial Ischemic Injury in Rats

Han, Cuihong; Lin, Li; Zhang, Weidong; Zhang, Li; Lv, Shijun; Sun, Qiang; Tao, Hengyi; Zhang, Junyi; Sun, Xuejun

doi:10.3181/0801-rm-8

Cited by 26 publications

(28 citation statements)

References 24 publications

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“…Expression of these genes can provide insights into the metabolic state of the tissue under different physiological conditions (Hooper and Hooper 2009;Hooper et al 2014). Evidence that HBOT can condition tissues to promote function and survival comes from the study of rat models of myocardial infarction (Han et al 2008;Sun et al 2011) and cerebral ischemia reperfusion injury (Li et al 2008(Li et al , 2009Cheng et al 2011), as well as a mouse model of repeated UV-A skin exposure (Fuller et al 2013). Whether or not HBOT can be used therapeutically in selected patient populations to alleviate tissue damage arising from chronic inflammation and oxidative stress remains to be determined.…”

mentioning

confidence: 99%

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Verma

Chopra

Giardina

et al. 2015

Cell Stress and Chaperones

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The disease burden from diabetic kidney disease is large and growing. Effective therapies are lacking, despite an urgent need. Hyperbaric oxygen therapy (HBOT) activates Nrf2 and cellular antioxidant defenses; therefore, it may be generally useful for treating conditions that feature chronic oxidative tissue damage. Herein, we determined how periodic exposure to oxygen at elevated pressure affected type 2 diabetes mellitus-related changes in the kidneys of db/db mice. Two groups of db/db mice, designated 2.4 ATA and 1.5 ATA, were treated four times per week with 100 % oxygen at either 1.5 or 2.4 ATA (atmospheres absolute) followed by tests to assess kidney damage and function. The sham group of db/db mice and the Hets group of db/+ mice were handled but did not receive HBOT. Several markers of kidney damage were reduced significantly in the HBOT groups including urinary biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CyC) along with significantly lower levels of caspase-3 activity in kidney tissue extracts. Other stress biomarkers also showed trends to improvement in the HBOT groups, including urinary albumin levels. Expressions of the stress response genes NRF2, HMOX1, MT1, and HSPA1A were reduced in the HBOT groups at the end of the experiment, consistent with reduced kidney damage in treated mice. Urinary albumin/creatinine ratio (ACR), a measure of albuminuria, was significantly reduced in the db/db mice receiving HBOT. All of the db/db mouse groups had qualitatively similar changes in renal histopathology. Glycogenated nuclei, not previously reported in db/db mice, were observed in these three experimental groups but not in the control group of nondiabetic mice. Overall, our findings are consistent with therapeutic HBOT alleviating stress and damage in the diabetic kidney through cytoprotective responses. These findings support an emerging paradigm in which tissue oxygenation and cellular defenses effectively limit damage from chronic oxidative stress more effectively than chemical antioxidants.

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mentioning

confidence: 99%

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Verma

Chopra

Giardina

et al. 2015

Cell Stress and Chaperones

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“…The animal model employed presently was established by occlusion of the anterior descending proximal artery (Han et al, 2008). Briefly, the rat was anaesthetized with Xylazine 8 mg kgG 1 and Ketamine at 100 mg kgG 1 , administered intraperitoneally.…”

Section: Animal Model Of Acute Myocardial Infarctionmentioning

confidence: 99%

“…The extent of this increase is in function of the number of exposures, the time of exposure and the levels of ATA (Simsek et al, 2011;Sheikh et al, 2000). In studies with a rat model of coronary heart disease, previous HBO treatment followed by myocardial infarction resulted in a reduction in the extent of heart tissue damage and a shorter recovery time (Han et al, 2008). This suggests the possible efficacy of HBO therapy to prevent AMI or reduce the damage to heart tissue of individuals who suffer this event.…”

Section: Introductionmentioning

confidence: 99%

“…After having had an acute myocardial infarction with unstable angina, patients who underwent a percutaneous coronary intervention were given HBO therapy as therapy to recover the risk zone, showing improved results (Han et al, 2008;Sharif et al, 2004). Subsequent to myocardial infarction, patients undergoing thrombolytic therapy received HBO as a coadjuvant, also showing better outcome (Shandling et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hyperbaric Oxygenation in Total Antioxidant System, Nitric Oxide and 3 Nitrotyrosine Levels in a Rat Model of Acute Myocardial Infarct in the Absence of Reperfusion

Guadalupe¹,

Carmen²,

Kormanovski³

et al. 2015

International J. of Pharmacology

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A B S T R A C TCoronary heart disease is one of the main causes of death worldwide. Only 10-15% of patients in Mexico receive the standard treatment (reperfusion therapy) leaving the vast majority without an effective remedy. One possible coadjuvant treatment after acute myocardial infarction is Hyperbaric Oxygen Therapy (HBO), which has shown beneficial effects in patients having pathologies with an ischemic origin. The HBO therapy is known to favor vascular regeneration and oxygenation of ischemic tissues and to stimulate an increase in antioxidant enzymes in tissues and plasma. The aim of this study was to evaluate the levels of enzymes of the antioxidant system and oxidative status in a rat model of Acute Myocardial Infarct (AMI) with HBO therapy. The anterior descending artery was surgically ligated to provoke AMI, Rats were grouped: without HBO and with HBO treatment (for 1, 3, 5, 10 or 20 sessions with 100% oxygen at 2 atmospheres for 60 min). After sacrifice, the heart was extracted to evaluate the left and right side for Total Antioxidant Response (TAS) and levels of nitric oxide and 3'nitrotyrosine. Left heart samples were taken from the ischemic area. In the left heart, the HBO therapy group had a higher level of 3'nitrotyrosine (compared to basal values) in the ischemic area at the 20th session. This indicates a greater production of NO, favoring better recovery in the ischemic area, improvement in the penumbra area and greater vascularization.

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“…19 Han et al showed that HBO preconditioning decreased infarct size and improved heart function in rat myocardial infarction. 20 In addition, Yogaratnam et al demonstrated that HBO preconditioning before coronary artery bypass graft surgery decreased myocardial damage, intraoperative blood loss, ICU length of stay, and postoperative complications. 21 Interestingly, in an experimental study, HBO therapy results in an otoprotection effect against Cisplatin-induced ototoxicity.…”

mentioning

confidence: 99%

Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

Saadat¹,

Maghani²,

Rahimi³

et al. 2013

Renal Failure

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Background: Cisplatin is a potent anticancer drug, but its nephrotoxicity limits the clinical use of it. To reduce the Cisplatin-induced nephrotoxicity, various interventions have been implicated. The aim of this study was to examine whether preconditioning with normobaric hyperoxia would prevent Cisplatin-induced nephrotoxicity in patient with solid tumor. Methods: In a prospective study, 80 adult patients with solid tumor who were treated with Cisplatin between February 2011 and December 2011 were included. Forty-three patients were exposed to pure oxygen via non-rebreathing reservoir mask which increased the provided oxygen rate to 60% oxygen for 2 hours at 48, 24, and 6 hours before intravenous administration of Cisplatin and 37 patients received only Cisplatin as a control group. Estimated glomerular filtration rate (eGFR) calculated in all patients on day 1 before and on days 1, 3, 6, 30 after Cisplatin exposures. Results: Patients treated with Cisplatin and 60% oxygen showed a mild improvement in eGFR and mild reduction of serum creatinine after 30 days with statistically mild significant differences (p ¼ 0.048). Conclusion: This study showed that normobaric and intermittent precondition of 60% oxygen prior to Cisplatin treatment had an acute transient adverse effect on renal function; however, the improvement of renal function will be seen after 30 days. Thus, it may help to prevent Cisplatin nephrotoxicity.

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Hyperbaric Oxygen Preconditioning Alleviates Myocardial Ischemic Injury in Rats

Cited by 26 publications

References 24 publications

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Effect of Hyperbaric Oxygenation in Total Antioxidant System, Nitric Oxide and 3 Nitrotyrosine Levels in a Rat Model of Acute Myocardial Infarct in the Absence of Reperfusion

Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

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