Hyperbaric oxygen in the treatment of gas gangrene and clostridial infection: A report of 40 patients treated in a single-person hyperbaric oxygen chamber

Slack, W. K.; Hanson, Gillian C.; Chew, H. E. R.

doi:10.1002/bjs.1800560708

Cited by 30 publications

(10 citation statements)

References 17 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IN the 10 years between 1964 and 1973, 88 patients with gas gangrene or related infection have been treated at the Regional Hyperbaric Oxygen Unit, Whipps Cross Hospital, London. The number of cases now available for study provides a larger series than that previously reported from this centre (Slack et al, 1969).…”

mentioning

confidence: 87%

See 1 more Smart Citation

Gas gangrene and related infection: Classification, clinical features and aetiology, management and mortality. A report of 88 cases

Darke

King

Slack

1977

British Journal of Surgery

Self Cite

107

View full text Add to dashboard Cite

The clinical features of gas gangrene and related infection seen in 88 patients over a 10-year period are described. It is suggested that clostridial infection could be simply classified as either 'gas-forming' or 'non-gas-forming'. The gas-forming group represents the more severe form of infection. Non-clostridial gas gangrene may present in a variety of forms. The anaerobic streptococcus was the organism most frequently responsible, but these cases were indistinguishable from clostridial infection on clinical grounds. The treatment of gas gangrene in this series of patients is reported. Emphasis is laid on the importance of adequate prophylaxis with penicillin in patients at risk. The value of antibiotics in established infection remains equivocal. The evidence supporting the value of hyperbaric oxygen therapy is assessed and an attempt made to quantify the response to this treatment. Benefit was apparent in only a proportion of patients. A favourable response indicated clostridial infection and guaranteed immediate survival. Extensive debridement or amputation is unnecessary in this group. No response following hyperbaric oxygen therapy indicated widespread mixed clostridial and non-clostridial infection, or infection due to organisms other than clostridia. Urgent and extensive debridement and amputation remain the predominant measures in this group.

show abstract

mentioning

confidence: 87%

“…The treatment of gas gangrene and related infection is based upon general resuscitative measures (Slack et al, 1969) and specific therapy which consists of antibiotics, surgical debridement and hyperbaric oxygen therapy. These three aspects will be considered separately.…”

Section: Treatmentmentioning

confidence: 99%

Gas gangrene and related infection: Classification, clinical features and aetiology, management and mortality. A report of 88 cases

Darke

King

Slack

1977

British Journal of Surgery

Self Cite

107

View full text Add to dashboard Cite

show abstract

“…A subnormal temperature associated with a remarkably rapid pulse was usually indicative of a grave prognosis. 6. In striking contrast to the usual facial flush associated with pyogenic infections, a peculiar gray pallor often occurred in the general appearance of the patient.…”

Section: Diagnosis and Pitfalls In Diagno¬mentioning

confidence: 83%

Prevention and Treatment of Gas Gangrene

Altemeier¹

1971

JAMA

119

View full text Add to dashboard Cite

“…Most authors agree that in view of the risks of serum sickness and hypersensitivity, anti-gas gangrene serum has no place in the prevention or treatment of gas gangrene in any situation (Johnson, Gillespie & Cole, 1969;Schraibauan, 1968;Slack, Hanson & Chew, 1969).…”

Section: Discussionmentioning

confidence: 99%

Clostridial brain abscess and hyperbaric oxygen

Keogh¹

1973

Postgraduate Medical Journal

View full text Add to dashboard Cite

Summary The first case of ‘gas gangrene’ of the brain treated with hyperbaric oxygen is reported. It is suggested that there is no place in clostridial infection confined to the central nervous system for hyperbaric oxygen treatment. The early onset of symptoms in clostridial brain abscess with the presence of a gas bubble localizing the abscess were again confirmed. The importance of taking a careful history and obtaining skull radiographs in suspected penetrating wounds is stressed.

show abstract

Hyperbaric oxygen in the treatment of gas gangrene and clostridial infection: A report of 40 patients treated in a single-person hyperbaric oxygen chamber

Cited by 30 publications

References 17 publications

Gas gangrene and related infection: Classification, clinical features and aetiology, management and mortality. A report of 88 cases

Gas gangrene and related infection: Classification, clinical features and aetiology, management and mortality. A report of 88 cases

Prevention and Treatment of Gas Gangrene

Clostridial brain abscess and hyperbaric oxygen

Contact Info

Product

Resources

About