Hyperbaric oxygen (HBO) therapy for acute traumatic cervical spinal cord injury

Asamoto, Shunji; Sugiyama, Hiroyuki; Doi, Hiroshi; Iida, Masataka; Nagao, Takehiko; Matsumoto, Kiyoshi

doi:10.1038/sj.sc.3101023

Cited by 39 publications

(34 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, it may be effective in the treatment of incomplete spinal cord injury. 4 Our case as reported supported the value of hyperbaric oxygen treatment in patients with BSS.…”

Section: Discussionsupporting

confidence: 84%

Brown–Séquard syndrome due to penetrating injury by an iron fence point

Jia

Chen

et al. 2009

Spinal Cord

View full text Add to dashboard Cite

Study design: Case report. Objectives: To present an unusual type of penetrating objects causing Brown-Séquard syndrome (BSS) and its clinical character. Setting: Department of Orthopaedic Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, PR China. Methods: A 54-year-old man fell from a height of 4 m onto an iron fence, and a sharp iron fence point penetrated the right side of his back. He developed left-sided BSS. Both X-ray film and computed tomography scanning of the thoracic spine showed a right vertebral plate of Th5 fracture and metal fragments inclining through the posterior and left lateral of the spinal canal. Emergency decompressive laminectomy and removal of the foreign metal piece were performed. No improvement in neurological function was observed 10 days after surgery, and thus hyperbaric oxygen treatment was initiated twice a day for the next 1 month. Results: Forty days after surgery, his bladder function returned to normal. The motor deficit had regressed and he could walk without assistance 70 days after the operation. One year later, his lower extremity functions recovered almost completely, except for slight numbness on the right side. Conclusion: As far as we know, on the basis of existing literature, the injury mechanism to BSS by a sharp iron fence point has not been reported so far. The satisfactory recovery after injury may in part be attributed to timely surgery and continuing hyperbaric oxygen treatment.

show abstract

“…In contrast, it may be effective in the treatment of incomplete spinal cord injury. 4 Our case as reported supported the value of hyperbaric oxygen treatment in patients with BSS.…”

Section: Discussionsupporting

confidence: 84%

Brown–Séquard syndrome due to penetrating injury by an iron fence point

Jia

Chen

et al. 2009

Spinal Cord

View full text Add to dashboard Cite

show abstract

“…HBO, which is widely performed for patients in hypoxic condition, is an attractive method of treatment that has frequently been used for several neurological diseases. [3][4][5][6][7] HBO therapy has been shown to decrease tissue edema, improve blood flow, and promote oxygen delivery, leading to an increase in the oxygen level in neuronal tissues and enhancement of cellular and metabolic functions. 8 Arterial oxygen pressure and content were increased after HBO treatment, with a 20% improvement of oxygen supply to the ischemic periphery.…”

Section: Discussionmentioning

confidence: 99%

“…20 HBO therapy has also been clinically reported to promote neurological recovery after spinal cord injury or surgical treatment of cervical myelopathy. 6,7 We believe that HBO might facilitate the recovery of reversibly injured cells by improving the hypoxic condition of neural tissue at risk, though it has no effect on the recovery of irreversibly injured cells. In the CSA patients of the present study, we speculate that oxygen supply to reversibly injured anterior horn cells under hypoxic conditions by HBO treatment might result in improvement of energy failure and subsequent reinnervation of the atrophic muscles, leading to improvement of muscle strength.…”

Section: Discussionmentioning

confidence: 99%

Conservative treatment with hyperbaric oxygen therapy for cervical spondylotic amyotrophy

et al. 2011

View full text Add to dashboard Cite

Study design: Small case series of patients with cervical spondylotic amyotrophy (CSA) managed by conservative treatment with hyperbaric oxygen (HBO) therapy. Objective: To study the effects of conservative treatment with HBO therapy of CSA patients. Setting: Department of Orthopaedic Surgery, Imakiire General Hospital, Kagoshima, Japan. Methods: This study included 10 patients with CSA who underwent rehabilitation, including cervical traction and muscle exercise, for some period of time but did not respond well to it, and were then managed by additional HBO therapy for rehabilitation. Information was obtained on the duration of symptoms and strength of the most atrophic muscle, intramedullary high-signal-intensity changes on T2-weighted magnetic resonance imaging, presence of 'snake-eyes' appearance and the number of stenotic canal levels. Results: The mean duration of symptoms before HBO treatment was 3.1 months. The axial T2-weighted magnetic resonance images of all 10 patients showed a 'snake-eyes' appearance. The mean number of stenotic canal levels was 0.3. There was marked improvement on manual muscle testing from a mean of 1.9 pretreatment to a mean of 4.4 at the last follow-up after HBO therapy. The outcomes of all 10 patients, whose results were classified as excellent or good, were considered clinically satisfactory. Conclusion: To our knowledge, conservative treatment with HBO therapy for CSA patients has not previously been described. It appears that HBO therapy might improve ischemic injury of the anterior horns in CSA patients with short duration of symptoms.

show abstract

“…On the other hand, the epidural varices at the thoracic level resulting in radiculopathy were located on the dorsal surface of the dural sac. 1,5) Suggested mechanisms for the development of varices include increased venous pressure and vein enlargement due to a protruded intervertebral disk, lumbar canal stenosis, 14) venous thrombosis from endothelial injury due to acute disk herniation, 19) epidural vein reflux in the valveless venous system due to increased thoraco-abdominal pressure induced by strain, lifting of a heavy load, or the Valsalva maneuver, 16) disturbance of blood outflow from the epidural venous plexus through the intervertebral veins into the inferior vena cava system result-…”

Section: Discussionmentioning

confidence: 99%

Radiculopathy Caused by Lumbar Epidural Venous Varix -Case Report-

Aoyama

Hida

Akino

et al. 2008

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 33-year-old man presented with a rare case of lumbar epidural venous varix causing radiculopathy manifesting as sciatica exacerbated during bowel movements. The left straight-leg raising test was positive and patellar tendon reflex was lost. Lumbar magnetic resonance imaging showed a mass lesion in the epidural space at the L4 level just anterior to the dural sac on the left, appearing as hypointense on T 1 -and hyperintense on T 2 -weighted images, with ring-like enhancement with gadopentetate dimeglumine. He underwent surgery under a preoperative diagnosis of cystic nerve sheath tumor. After left hemilaminectomy, intraoperative ultrasonography showed a low echoic mass lesion ventral to the L4 nerve root. The mass was dark blue with a smooth wall. Tearing of the wall resulted in continuous bleeding. After removal of the lesion, we confirmed that the dura of the nerve root was intact. Histological examination of the surgical specimen confirmed venous tissue. The postoperative course was excellent. Lumbar epidural varix is difficult to diagnose preoperatively. Lumbar epidural varix should be considered if the lesion is smaller on preoperative than intraoperative imaging, or disappears with bleeding cessation, as this may avoid unnecessary widening of the operative field. The correct preoperative diagnosis remains difficult, so we recommend surgical removal and histological confirmation.

show abstract

Hyperbaric oxygen (HBO) therapy for acute traumatic cervical spinal cord injury

Cited by 39 publications

References 4 publications

Brown–Séquard syndrome due to penetrating injury by an iron fence point

Brown–Séquard syndrome due to penetrating injury by an iron fence point

Conservative treatment with hyperbaric oxygen therapy for cervical spondylotic amyotrophy

Radiculopathy Caused by Lumbar Epidural Venous Varix -Case Report-

Contact Info

Product

Resources

About