Hyperbaric oxygen exposure temporarily reduces Mac-1 mediated functions of human neutrophils

Kalns, John; Lane, Janae; Delgado, Ángel Acuña; Scruggs, Julie; Ayala, Eleanor; Gutierrez, Elizabeth; Warren, Doug; Niemeyer, D. H.; Wolf, Eckhard; Bowden, Robert A.

doi:10.1016/s0165-2478(02)00068-8

Cited by 33 publications

(32 citation statements)

References 24 publications

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“…Administration of MAB to CD18 in the microcirculation IR model blocked neutrophil adhesion and subsequent arteriole vasoconstriction associated with IR, suggesting that HBO affects CD18 [7]. Other studies showed that HBO and a MAB to CD18 inhibited the adhesion of activated PMNs to nylon columns, fibronectin-coated glass, or endothelial cells [6,29]. Experiments evaluating quantitative CD18 expression by flow cytometry revealed that, while IR increases quantitative expression of CD18 versus controls, HBO does not alter this expression [13].…”

Section: Discussionmentioning

confidence: 94%

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Reperfusion-Induced Neutrophil CD18 Polarization: Effect of Hyperbaric Oxygen

Khiabani

Bellister

Skaggs

et al. 2008

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 94%

“…Research evaluating the CD18 neutrophil adhesion molecule has given some insight regarding the mechanism of HBO therapy [6,7,29]. Administration of MAB to CD18 in the microcirculation IR model blocked neutrophil adhesion and subsequent arteriole vasoconstriction associated with IR, suggesting that HBO affects CD18 [7].…”

Section: Discussionmentioning

confidence: 99%

Reperfusion-Induced Neutrophil CD18 Polarization: Effect of Hyperbaric Oxygen

Khiabani

Bellister

Skaggs

et al. 2008

Journal of Surgical Research

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“…HBO protected renal functions as well as significantly decreased the number of infiltrated neutrophils in rat kidneys after I/R injury. It has been shown that HBO decreases neutrophil infiltration by inhibiting neutrophil ␤ 2 -integrin (CD11/CD18) function [20,21] as well as the expression of ICAM-1 on endothelial cells [6,22] after I/R injury. Inhibition of leukocyte adhesion with HBO in I/R injury is directly related to the pressure of the oxygen exposed.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Attenuates Renal Ischemia/Reperfusion Injury in Rats

Solmazgül¹,

Uzun

Çermik³

et al. 2007

Urol Int

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Objective: Renal ischemia/reperfusion (I/R) injury occurs in both native and transplanted kidneys. Hyperbaric oxygen (HBO) has been shown to prevent I/R injury in different tissues. The aim of this study was to evaluate the effect of HBO on renal I/R injury in rats. Materials and Methods: Sprague-Dawley rats were randomly assigned to one of three groups. The Control group (n = 6) received right nephrectomy. The I/R (n = 6) and I/R+HBO groups (n = 6) received 30 min left renal ischemia followed by 24 h of reperfusion after right nephrectomy. The I/R+HBO group (n = 6) received additional HBO therapy for 60 min at 2.5 absolute atmospheres starting at the initial 15th minute of reperfusion. Results: In the I/R group, blood urea nitrogen (BUN) and creatinine levels increased significantly compared with the Control and I/R+HBO groups (p < 0.05). BUN and creatinine levels were similar in the Control and I/R+HBO groups. Kidney samples from I/R group rats revealed severe tubular damage and neutrophil infiltration at histopathological examination. The animals treated with HBO showed markedly improved lesions and less neutrophil infiltration compared with the I/R group (p < 0.05). Conclusions: HBO exhibited marked protection against I/R injury in this study as measured using BUN and creatinine levels and renal histopathology. However, further studies are needed to clarify the renoprotective effect of HBO on I/R injury.

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“…41 Its general anti-inflammatory effects are clearly demonstrated in "zymosan" models of shock, in which HBO attenuates the inflammatory response and reduces mortality. [42][43][44] All these features may significantly improve outcomes in severe pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Reduces Severity and Improves Survival in Severe Acute Pancreatitis

Nikfarjam

Cuthbertson

Malcontenti‐Wilson

et al. 2007

Journal of Gastrointestinal Surgery

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Severe acute pancreatitis is characterized by pancreatic necrosis, resulting in local and systemic inflammation. Hyperbaric oxygen (HBO) therapy modulates inflammation, but has not been extensively studied in pancreatitis. This study investigates the effects of HBO in a rat model of severe acute pancreatitis. Sixty-four rats were induced with severe pancreatitis using 4% sodium taurocholate and randomized to HBO treatment or control. HBO was commenced 6 h after induction (100% oxygen at 2.5 atmospheres for 90 min) and continued every 12 h for a maximum of eight treatment episodes. Surviving animals were killed at 7 days. Severity of pancreatitis was graded macroscopically and microscopically. Lung edema was calculated using wet and dry lung weights. Macroscopic and microscopic severity scores (mean +/- SE) of HBO-treated animals with pancreatitis (8.3 +/- 0.7; 9.6 +/- 0.4) were lower than those of controls (10.5 +/- 0.5; 11.1 +/- 0.4) (p = 0.02 and p = 0.03, respectively). The HBO-treated group had reduced pancreatic necrosis compared to controls (40 +/- 4% vs. 54 +/- 4%; p = 0.003). There was no difference in pulmonary edema between the groups. Median survival in the HBO-treatment group was 51 h, compared to 26 h in controls. Day-7 survival was significantly improved in the HBO-treated animals compared to controls (40% vs. 27%; p = 0.04). HBO therapy reduces overall severity, decreases the extent of necrosis, and improves survival in severe acute pancreatitis.

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Hyperbaric oxygen exposure temporarily reduces Mac-1 mediated functions of human neutrophils

Cited by 33 publications

References 24 publications

Reperfusion-Induced Neutrophil CD18 Polarization: Effect of Hyperbaric Oxygen

Reperfusion-Induced Neutrophil CD18 Polarization: Effect of Hyperbaric Oxygen

Hyperbaric Oxygen Therapy Attenuates Renal Ischemia/Reperfusion Injury in Rats

Hyperbaric Oxygen Therapy Reduces Severity and Improves Survival in Severe Acute Pancreatitis

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