Hyperbaric Oxygen Exposure Improves Blood Glucose Level and Muscle Oxidative Capacity in Rats with Type 2 Diabetes

Gu, Ning; Nagatomo, Fumiko; Fujino, Hidemi; Takeda, Isao; Tsuda, Kinsuke; Ishihara, Akihiko

doi:10.1089/dia.2009.0104

Cited by 26 publications

(32 citation statements)

References 42 publications

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“…Fiber type shifts occur under a variety of conditions, such as growth, aging, disease, and increased or decreased muscle activity [34]. To our knowledge, no previous studies have reported the shift of all fibers to a single type-with the exception of our finding that the soleus muscles in adult rats with type 2 diabetes contain only type I fibers that have lower oxidative enzyme activity than type IIA and IIC fibers [9][10][11][12]. However, the mechanism underlying the complete shift of fibers to a single type in the soleus muscles of CP-Ex rats remains unclear.…”

Section: Discussionmentioning

confidence: 70%

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The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome

et al. 2012

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Skeletal muscles in animals with metabolic syndrome exhibit reduced oxidative capacity. We investigated the effects of running exercise on fiber characteristics, oxidative capacity, and mRNA levels in the soleus muscles of rats with metabolic syndrome [SHR/NDmcr-cp (cp/cp); CP]. We divided 5-week-old CP rats into non-exercise (CP) and exercise (CP-Ex) groups. Wistar-Kyoto rats (WKY) were used as the control group. CP-Ex rats were permitted voluntary exercise on running wheels for 10 weeks. Triglyceride levels were higher and adiponectin levels lower in the CP and CP-Ex groups than in the WKY group. However, triglyceride levels were lower and adiponectin levels higher in the CP-Ex group than in the CP group. The soleus muscles in CP-Ex rats contained only high-oxidative type I fibers, whereas those in WKY and CP rats contained type I, IIA, and IIC fibers. Muscle succinate dehydrogenase (SDH) activity was higher in the CP-Ex group than in the CP group; there was no difference in SDH activity between the WKY and CP-Ex groups. Muscle proliferator-activated receptor γ coactivator-1α (PGC-1α) mRNA levels were higher in the CP-Ex group than in the CP group; there was no difference in PGC-1α mRNA levels between the WKY and CP-Ex groups. In CP-Ex rats, longer running distance was associated with increased muscle SDH activity and PGC-1α mRNA levels. We concluded that running exercise restored decreased muscle oxidative capacity and PGC-1α mRNA levels and improved hypertriglyceridemia in rats with metabolic syndrome.

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Section: Discussionmentioning

confidence: 70%

“…The skeletal muscles in patients with type 2 diabetes contain a lower percentage of high-oxidative fibers than those in healthy individuals [5][6][7][8]. Furthermore, we observed that the soleus muscles in rats with type 2 diabetes contain a lower percentage of high-oxidative fibers than those in non-diabetic rats [9][10][11][12].…”

Section: Introductionmentioning

confidence: 88%

The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome

et al. 2012

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“…The proportion of low-oxidative type I fibers in the soleus muscle decreases and high-oxidative type IIA and IIC fibers, which are not detected in the soleus muscle of type 2 diabetic rats 37,38) , are observed after hyperbaric oxygen 40) . Hyperbaric oxygen reduces high glucose levels in GK rats during postnatal development and improves oxidative capacity in the soleus and plantaris muscles, and these effects are maintained under normobaric conditions after hyperbaric oxygen 42) (Fig. 10).…”

Section: Effect Of Mild Hyperbaric Oxygenmentioning

confidence: 92%

“…Muscle fiber specification appears to be associated with type 2 diabetes as well as metabolic syndrome and hypertension [37][38][39][40][41][42] (Table 3). Yasuda et al 37,38) found that both obese Otsuka Long-Evans Tokushima fatty (OLETF) and nonobese Goto-Kakizaki (GK) rats as animal models of type 2 diabetes exhibit a decreased proportion of high-oxidative type IIA and IIC fibers and an increased proportion of low-oxidative type I fibers in the soleus muscle during postnatal development.…”

Section: Skeletal Muscle Characteristics Of Animal Modelsmentioning

confidence: 99%

Lifestyle-related disease and skeletal muscle: A review

Ishihara

Nagatomo

Fujino

et al. 2012

JPFSM

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The skeletal muscles in animal models with metabolic syndrome and lifestyle-related diseases, e.g., type 2 diabetes, have decreased oxidative capacity, which is associated with reduced expression levels of the gene for peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). Running restores decreased oxidative capacity in the skeletal muscles of rats with metabolic syndrome and type 2 diabetes, and hypertriglyceridemia and hyperglycemia are improved, respectively. Longer running distances are associated with increased oxidative capacity and PGC-1α mRNA levels in the skeletal muscles of rats with metabolic syndrome and type 2 diabetes. In contrast, a high-fat diet reduces the muscle oxidative capacity and PGC-1α mRNA levels of rats with metabolic syndrome, and weight gain, hypertriglyceridemia, and hyperglycemia are accelerated. Recently, mild hyperbaric oxygen at 1.25 atmospheres absolute with 36% oxygen has been proven effective for hypertension and type 2 diabetes. Mild hyperbaric oxygen inhibits a growth-related increase in glucose levels and further decreases high glucose levels in adult rats with type 2 diabetes-changes that are associated with improvements in muscle oxidative capacity and PGC-1α mRNA levels. This paper is a review of the fiber type distribution, oxidative enzyme activity, mRNA levels, and capillary architecture of skeletal muscles in animal models with metabolic syndrome and lifestyle-related diseases. In addition, the effects of a high-fat diet, exercise, and mild hyperbaric oxygen have been summarized.

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“…In this context, hyperbaric oxygen treatment was reported to reduce blood-glucose levels in diabetic mice and rats. [19][20][21] Therefore, this study examined whether chronic high glucose (CHG) causes cellular hypoxia in rat INS-1 β cells, and whether hyperoxia can reverse glucotoxicityinduced inhibition of insulin secretion.…”

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confidence: 99%

Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells

Matsunaga

Adachi

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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Hyperbaric Oxygen Exposure Improves Blood Glucose Level and Muscle Oxidative Capacity in Rats with Type 2 Diabetes

Abstract: Exposure to hyperbaric oxygen reduces high blood glucose levels and improves oxidative capacities in the skeletal muscles of rats with diabetes, and these effects are maintained under normobaric conditions even after exposure to hyperbaric oxygen.

Cited by 26 publications

References 42 publications

The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome

The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome

Lifestyle-related disease and skeletal muscle: A review

Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells

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