Hyperbaric Oxygen as Radiation Sensitizer for Locally Advanced Squamous Cell Carcinoma of the Oropharynx: A Phase 1 Dose-Escalation Study

Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review

“…45 Other benefits of HBOT may include tumor sensitization to radiation, improved dental implant survival rates, amelioration of xerostomia symptoms, and better quality-of-life scores. [46][47][48][49][50][51][52][53] Experimental studies in mice also suggest HBOT may positively affect muscle growth in irradiated tissues, which could potentially protect against dysphagia. 54 The benefits of HBOT must be weighed against the high cost and relative rarity of HBOT facilities, which create a barrier to access for most patients.…”

Justifying Hyperbaric Oxygen Delivery for Carbon Monoxide Poisoning

“…Despite its academic nadir in years past, the field of hyperbaric medicine has gradually demonstrated efficacy for a number of indications in clinical medicine through a variety of published reports over the past several decades-from studies showing mobilization of bone marrow-derived stem/progenitor cells by a free radical mechanism in a hyperbaric environment 6 to the use of hyperbaric therapies as an adjunctive measure in the treatment of malignancies. [7][8][9] Although administration of supplemental oxygen is the primary treatment for CO exposure, the use of HBOT to deliver supplemental oxygen remains inconclusive as a primary treatment strategy. Following several unblinded studies concluding that neurologic outcomes were more favorable in patients receiving HBOT compared with those receiving standard normobaric oxygen therapies for CO poisoning, a meta-analysis published in 2005 and updated in 2011 concluded that there was no significant alteration in neurologic sequelae involving four of six randomized controlled trials (RCTs) involving the use of HBOT for treatment of CO exposure at that time.…”