Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

Maier, Andrea B.; Anegg, Udo; Fell, B.; Rehak, Peter; Ratzenhofer, B; Tomaselli, Florian; Sankin, Oliver; Pintér, H; Smolle‐Jüttner, Freyja Maria; Friehs, G

doi:10.1002/(sici)1096-9101(2000)26:3<308::aid-lsm9>3.3.co;2-2

Cited by 9 publications

(15 citation statements)

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“…There are recent reports of PDT delivered inside a hyperbaric chamber for various indications (65)(66)(67)(68)(69)(70). Although the results are not conclusive they have shown that hyperoxygenation has extended the survival period in patients with carcinoma of the esophagus and the esophago-gastic junction (68).…”

Section: Discussionmentioning

confidence: 99%

Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶

Chen¹,

Huang²,

Chen³

et al. 2007

Photochemistry and Photobiology

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Photodynamic therapy (PDT) requires molecular oxygen during light irradiation to generate reactive oxygen species. Tumor hypoxia, either preexisting or induced by PDT, can severely hamper the effectiveness of PDT. Lowering the light irradiation dose rate or fractionating a light dose may improve cell kill of PDT‐induced hypoxic cells but will have no effect on preexisting hypoxic cells. In this study hyperoxygenation technique was used during PDT to overcome hypoxia. C3H mice with transplanted mammary carcinoma tumors were injected with 12.5 mg/kg Photofrin® and irradiated with 630 nm laser light 24 h later. Tumor oxygenation was manipulated by subjecting the animals to 3 atp (atmospheric pressure) hyperbaric oxygen or normobaric oxygen during PDT light irradiation. The results show a significant improvement in tumor response when PDT was delivered during hyperoxygenation. With hyperoxygenation up to 80% of treated tumors showed no regrowth after 60 days. In comparison, when animals breathed room air, only 20% of treated tumors did not regrow. To explore the effect of hyperoxygenation on tumor oxygenation, tumor partial oxygen pressure was measured with microelectrodes positioned in preexisting hypoxic regions before and during the PDT. The results show that hyperoxygenation may oxygenate preexisting hypoxic cells and compensate for oxygen depletion induced by PDT light irradiation. In conclusion, hyperoxygenation may provide effective ways to improve PDT efficiency by oxygenating both preexisting and treatment‐induced cell hypoxia.

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Section: Discussionmentioning

confidence: 99%

Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶

Chen¹,

Huang²,

Chen³

et al. 2007

Photochemistry and Photobiology

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“…148, 149 Hyperbaric oxygen therapy which entails the use of pressurization to deliver increased oxygen concentration to the body and especially in the tumour has been developed. 147, 150 Since the 1970s, this strategy has been introduced in clinical trials with patients undergoing radiotherapy in hyperbaric oxygen chambers in an attempt to force more oxygen into blood and into the tumours. 150 Indeed, breathing hyperbaric oxygen can increase the pressure of oxygen (pO 2 ) in tissues of the patient.…”

Section: Oxygen Self-supplementmentioning

confidence: 99%

“…147, 150 Since the 1970s, this strategy has been introduced in clinical trials with patients undergoing radiotherapy in hyperbaric oxygen chambers in an attempt to force more oxygen into blood and into the tumours. 150 Indeed, breathing hyperbaric oxygen can increase the pressure of oxygen (pO 2 ) in tissues of the patient. For example, pO 2 of skin dermis increases from about 50 torr when breathing air (20% oxygen) to 150-350 torr during the breathing of 100% oxygen at 1 atm.…”

Section: Oxygen Self-supplementmentioning

confidence: 99%

“…156 Studies have shown that the combined hyperbaric oxygen therapy and PDT may enhance the effectiveness of PDT compared with PDT alone. 46, 150 Although PS dosage and light dosimetry have been well standardized in PDT procedures, the oxygen level and the hypoxic microenvironment within tumours cannot be controlled, leading to ambiguous outcomes in a number of PDT studies.…”

Section: Oxygen Self-supplementmentioning

confidence: 99%

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Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.

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“…By supplementing oxygen, we may improve PDT efficacy in the treatment of hypoxic tumors. The use of normobaric or hyperbaric oxygen to compensate for tissue hypoxia and oxygen depletion during clinical PDT is reported (16)(17)(18)(19)(20). Our previous in vivo study has shown that by subjecting animals to hyperoxygenation (i.e.…”

Section: Introductionmentioning

confidence: 99%

Hyperoxygenation Enhances the Tumor Cell Killing of Photofrin-mediated Photodynamic Therapy¶

Huang

Chen

Shakil

et al. 2007

Photochemistry and Photobiology

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Tumor hypoxia, either preexisting or as a result of oxygen depletion during photodynamic therapy (PDT) light irradiation, can significantly reduce the effectiveness of PDT‐induced cell killing. To overcome tumor hypoxia and improve tumor cell killing, we propose using supplemental hyperoxygenation during Photofrin‐PDT. The mechanism for the tumor cure enhancement of the hyperoxygenation–PDT combination is investigated using an in vivo–in vitro technique. A hypoxic tumor model was established by implanting mammary adenocarcinoma in the hind legs of mice. Light irradiation (200 J/cm2 at either 75 or 150 mW/cm2), under various oxygen supplemental conditions (room air, carbogen, 100% normobaric or hyperbaric oxygen), was delivered to animals that received 12.5 mg/kg Photofrin 24 h before light irradiation. Tumors were harvested at various time points after PDT and grown in vitro for colony formation analysis. Treated tumors were also analyzed histologically. The results show that when PDT is combined with hyperoxygenation, the hypoxic condition could be improved and the cell killing rate at various time points after PDT could be significantly enhanced over that without hyperoxygenation, suggesting an enhanced direct and indirect cell killing associated with high‐concentration oxygen breathing. This study further confirms our earlier observation that when a PDT treatment is combined with hyperoxygenation it can be more effective in controlling hypoxic tumors.

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Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

Cited by 9 publications

References 0 publications

Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶

Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Hyperoxygenation Enhances the Tumor Cell Killing of Photofrin-mediated Photodynamic Therapy¶

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