Hyperbaric Environment: Oxygen and Cellular Damage versus Protection

Poff, Angela M.; Kernagis, Dawn; D’Agostino, Dominic P.

doi:10.1002/cphy.c150032

Cited by 35 publications

(59 citation statements)

References 188 publications

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“…Dalam lingkungan yang terapeutik, diberikan jumlah oksigen yang telah dilarutkan dalam plasma yang dapat mencapai dan lebih tinggi 20 kali dari udara ruangan pada tekanan atmosfer normal. Plasma yang kaya oksigen kemudian diangkut ke jaringan yang mengalami hipoksia atau iskemik untuk mencegah terjadinya angiogenesis, edema, dan mampu memodulasi respons sistem imun dan kekebalan (Ilmi et al, 2017;Poff, Kernagis, & D'Agostino, 2011).…”

Section: Pendahuluanunclassified

“…Untuk prinsip inilah pengobatan dengan oksigenasi hiperbarik membantu memperbaiki jaringan perfusi, hipoksia, iskemik, infark atau nekrotik yang buruk. Oksigenasi terbaik memungkinkan untuk memicu proses pemulihan jaringan dan, selain itu, memfasilitasi reperfusi dan angiogenesis (Landolfi et al, 2006;Poff et al, 2011;Stephen R Thom, 2011).…”

Section: Pendahuluanunclassified

“…Efektivitas terapi oksigen hiperbarik harus selalu dievaluasi sebagai terapi ajuvan dalam pengobatan dengan dasar patologi yang melibatkan hipoperfusi, infeksi, iskemia atau proses infark, yang jika digunakan dengan tepat dan baik, dapat membantu pasien untuk sembuh, pulih dalam waktu yang lebih singkat, memiliki lebih sedikit gejala sisa sehingga penting sebagai sensitivitas atau fungsi, yang secara langsung akan mempengaruhi kualitas hidup, sosialisasi, produktivitas dan kualitas hidup pasien. (Huchim et al, 2017;Poff et al, 2011).…”

Section: Pendahuluanunclassified

See 2 more Smart Citations

Mekanisme yang Terlibat dalam Terapi Oksigen Hiperbarik: theoritical review hyperbaric oxygen therapy/HBOT

Rosyanti

Hadi

Rahayu

et al. 2019

HIJP

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ABSTRAKTerapi Oksigen Hiperbarik (HBOT) semakin sering digunakan di berbagai bidang medis, perawatan, dan praktik kesehatan. Menjadi intervensi penting dengan mekanisme tindakan yang tidak dipahami dengan baik. Terapi Oksigen Hiperbarik adalah salah satu metode pengobatan yang dilakukan dengan menyediakan 100% oksigen murni yang dihirup oleh pasien di ruangan khusus dengan udara bertekanan tinggi. Tekanan udara yang meningkat pada ruang Hiperbarik menyebabkan paru pasien menyerap lebih banyak oksigen daripada biasanya, yang dapat membantu menyembuhkan berbagai penyakit. Diharapkan adanya kajian ilmiah, ulasan dan diskusi tentang terapi heperbaric dan pencarian literatur tentang penggunaannya dapat bermanfaat bagi tim medis baik perawat, dokter, pekerja kesehatan lainnya dan masyarakat, sehingga mereka dapat meningkatkan pengetahuan, berdasarkan fisiologi, patologi, fisika, farmakologi, manfaat, indikasi dan perawatan tentang terapi hiperbarik sehingga dapat diterapkan dalam berbagai bidang yang diperlukan.Kata kunci: Hiperbarik, Mekanisme, Terapi oksigen, Tinjauan teoritis abstract Hyperbaric oxygen therapy (HBOT; Hyperbaric Oxygen Therapy) is increasingly being used in various fields of medical, nursing, and health practice. Being an important intervention with a mechanism of action that is not well understood. Hyperbaric oxygen therapy is one of the treatment methods performed by providing 100% pure oxygen which is inhaled by patients in a special room with high pressure air. Increased air pressure in the hyperbaric chamber causes the patient's lungs to absorb more oxygen than usual, which can help cure various diseases. It is expected that the existence of scientific studies, reviews and discussions of heperbaric therapy and literature search on their use can be beneficial to medical teams both nurses, doctors, other health workers and the community, so that they can increase knowledge, based on physiology, pathology, physics, pharmacology, benefits, indications and treatments about hyperbaric therapy so that it can be applied in various fields as needed.

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Section: Pendahuluanunclassified

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Mekanisme yang Terlibat dalam Terapi Oksigen Hiperbarik: theoritical review hyperbaric oxygen therapy/HBOT

Rosyanti

Hadi

Rahayu

et al. 2019

HIJP

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“…Accumulating evidence indicates that increased ROS may be fundamental in HBO therapy, in addition to the effects of increasing oxygen supply to alleviate tissue hypoxia [10,11]. Although, excessive HBO exposure would cause a massive ROS accumulation and lead to oxygen toxicity [11]. Modest increase of intracellular ROS during routine HBO treatment can modulate signaling pathways and induce the expression of cytoprotective proteins, thus enhancing cellular tolerance of harmful stimuli [12].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Approach to Estimate ROS Origination by Hyperbaric Oxygen Exposure, Targeted Probes and Specific Inhibitors

Zhou¹,

Huang²,

Yu³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Reactive oxygen species (ROS) are considered fundamental in various physiological/pathophysiological processes and prevention/treatment measures such as hyperbaric oxygen (HBO) therapy. In this study, the origination of ROS in human umbilical vein endothelial cells was investigated under basal and HBO conditions. Methods: Whole cell or mitochondria-targeted fluorescent probes were applied to mark superoxide anion (O₂^-), and the ROS produced from mitochondrial respiratory chain (MRC), NADPH oxidase (NOX) and xanthine oxidase (XO) were identified by flow cytometry, confocal imaging and microplate fluorometry with or without specific inhibitors. An algorithm was established to calculate ROS proportion of each source. Results: HBO increased ROS to about 2.14-2.44 fold in mitochondria and 1.32-1.42 fold in whole cell. Then ROS levels were significantly decreased by MRC inhibition about 30% and 16%, respectively. NOX or XO inhibition did not affect HBO-induced ROS generation. Based on these data, it could be further estimated that mitochondrial ROS accounted for 32%-39% of basal whole-cell ROS including 3% from MRC complex II, and NOX accounted for at least 24%-29%. Following HBO treatment, almost all increased ROS originated from mitochondria, and MRC complex II contributed at least 45%-60%. Conclusion: This study provided a simple but effective method to estimate the origination of intracellular ROS and found that MRC were the main source of HBO-induced ROS generation.

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Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges

et al. 2022

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Gaseous molecules have been increasingly explored for therapeutic development. Here, following an analytical background introduction, a systematic review of medical gas research is presented, focusing on tissue protections, mechanisms, data tangibility, and translational challenges. The pharmacological efficacies of carbon monoxide (CO) and xenon (Xe) are further examined with emphasis on intracellular messengers associated with cytoprotection and functional improvement for the CNS, heart, retina, liver, kidneys, lungs, etc. Overall, the outcome supports the hypothesis that readily deliverable "biological gas" (CO, H 2 , H 2 S, NO, O 2 , O 3 , and N 2 O) or "noble gas" (He, Ar, and Xe) treatment may preserve cells against common pathologies by regulating oxidative, inflammatory, apoptotic, survival, and/or repair processes. Specifically, CO, in safe dosages, elicits neurorestoration via igniting sGC/cGMP/MAPK signaling and crosstalk between HO-CO, HIF-1𝜶/VEGF, and NOS pathways. Xe rescues neurons through NMDA antagonism and PI3K/Akt/HIF-1𝜶/ERK activation. Primary findings also reveal that the need to utilize cutting-edge molecular and genetic tactics to validate mechanistic targets and optimize outcome consistency remains urgent; the number of neurotherapeutic investigations is limited, without published results from large in vivo models. Lastly, the broad-spectrum, concurrent multimodal homeostatic actions of medical gases may represent a novel pharmaceutical approach to treating critical organ failure and neurotrauma.

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Hyperbaric Environment: Oxygen and Cellular Damage versus Protection

Cited by 35 publications

References 188 publications

Mekanisme yang Terlibat dalam Terapi Oksigen Hiperbarik: theoritical review hyperbaric oxygen therapy/HBOT

Mekanisme yang Terlibat dalam Terapi Oksigen Hiperbarik: theoritical review hyperbaric oxygen therapy/HBOT

A Novel Approach to Estimate ROS Origination by Hyperbaric Oxygen Exposure, Targeted Probes and Specific Inhibitors

Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges

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