Hyperalgesia, nerve infiltration and nerve growth factor expression in deep adenomyotic nodules, peritoneal and ovarian endometriosis

Anaf, Vincent; Simon, Philippe; Nakadi, Issam El; Fayt, Isabelle; Simonart, Thierry; Buxant, Frédéric; Jc, Noël

doi:10.1093/humrep/17.7.1895

Cited by 280 publications

(232 citation statements)

References 24 publications

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“…It is likely that growth factors are involved in the coordinated reinnervation and vascularization of transplants (30,31) and may contribute to innervation of the ectopic endometrial growths. Thus, of relevance to ENDO in women, Anaf et al (7) found that nerve growth factor expression was greater in deeply infiltrating adenomyotic endometrial nodules when compared with other ectopic endometrial growths and that these nodules were located closer to nerve fibers.…”

Section: Discussionmentioning

confidence: 97%

“…Another group used S-100 protein as a marker for nerve fibers to compare samples of deeply infiltrating adenomyotic endometrial growths with other growths. The percentage of patients complaining of pain was greater in women with adenomyotic growths than other growths, and the adenomyotic growths were more likely to infiltrate nerves (7). No study, however, has investigated whether the ectopic growths develop their own nerve supply.…”

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confidence: 99%

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Innervation of ectopic endometrium in a rat model of endometriosis

Berkley

Dmitrieva

Curtis

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

195

161

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Endometriosis (ENDO) is a disorder in which vascularized growths of endometrial tissue occur outside the uterus. Its symptoms include reduced fertility and severe pelvic pain. Mechanisms that maintain the ectopic growths and evoke symptoms are poorly understood. One factor not yet considered is that the ectopic growths develop their own innervation. Here, we tested the hypothesis that the growths develop both an autonomic and a sensory innervation. We used a rat model of surgically induced ENDO whose growths mimic those in women. Furthermore, similar to women with ENDO, such rats exhibit reduced fertility and increased pelvic nociception. The ENDO was induced by autotransplanting, on mesenteric cascade arteries, small pieces of uterus that formed vascularized cysts. The cysts and healthy uterus were harvested from proestrous rats and immunostained using the pan-neuronal marker PGP9.5 and specific markers for calcitonin gene-related peptide (CGRP) (sensory C and A␦ fibers), substance P (SP) (sensory C and A␦ fibers) and vesicular monoamine transporter (sympathetic fibers). Cysts (like the uterus) were robustly innervated, with many PGP9.5-stained neurites accompanying blood vessels and extending into nearby luminal epithelial layers. CGRP-, SP-, and vesicular monoamine transporter-immunostained neurites also were observed, with CGRP and SP neurites extending the furthest into the cyst lining. These results demonstrate that ectopic endometrial growths develop an autonomic and sensory innervation. This innervation could contribute not only to symptoms associated with ENDO but also to maintenance of the ectopic growths.uterus ͉ fertility ͉ pain ͉ transplant ͉ neuropeptides

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Innervation of ectopic endometrium in a rat model of endometriosis

Berkley

Dmitrieva

Curtis

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

195

161

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“…MCs are likely to sensitize primary nociceptive neurons by the release of nerve growth factor (NGF) and proinflammatory cytokines. Lesional NGF can, in turn, attract MCs and trigger their degranulation [24].…”

Section: Mast Cells In Ems: a Painful Liaison?mentioning

confidence: 99%

Mast cells in endometriosis: guilty or innocent bystanders?

Kirchhoff

Kaulfuß

Fuhrmann

et al. 2012

Expert Opinion on Therapeutic Targets

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“…14,25 Endometrial cells then invade the epineurium and perineurium of the lumbosacral nerves. [3][4][5]25,40 Furthermore, studies examining endometriotic nociception have shown that endometrial cells possess considerable neurotropic properties, 26 secreting factors such as nerve growth factor, which stimulates neurite growth. Mechanisms allowing endometrial cells to migrate, adhere, and infiltrate nervous tissue are under investigation, but involve the complex interactions of integrins, cadherins, and matrix metalloproteinases.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis of the conus medullaris causing cyclic radiculopathy

Steinberg¹,

Gonda²,

Muller³

et al. 2014

SPI

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Intramedullary spinal cord hematomas are a rare neurosurgical pathological entity typically arising from vascular and neoplastic lesions. Endometriosis is an extremely rare cause of intramedullary spinal cord hematoma, with only 5 previously reported cases in the literature. Endometriosis is characterized by ectopic endometrial tissue, typically located in the female pelvic cavity, that causes a cyclical pain syndrome, bleeding, and infertility. In the rare case of intramedullary endometriosis of the spinal cord, symptoms include cyclical lower-extremity radiculopathies and voiding difficulties, and can acutely cause cauda equina syndrome. The authors report a case of endometriosis of the conus medullaris, the first to include radiological, intraoperative, and histopathological imaging. A brief review of the literature is also presented, with discussion including etiological theories surrounding intramedullary endometriosis.

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Hyperalgesia, nerve infiltration and nerve growth factor expression in deep adenomyotic nodules, peritoneal and ovarian endometriosis

Abstract: These results suggest a role of NGF in endometriotic pain and hyperalgesia in deep adenomyotic nodules. The strong expression of the NGF-TrkA pathway in deep adenomyotic nodules could explain why this type of lesion infiltrates in richly innervated anatomical sites.

Cited by 280 publications

References 24 publications

Innervation of ectopic endometrium in a rat model of endometriosis

Innervation of ectopic endometrium in a rat model of endometriosis

Mast cells in endometriosis: guilty or innocent bystanders?

Endometriosis of the conus medullaris causing cyclic radiculopathy

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