Hyperadiponectinemia in Newborns: Relationship with Leptin Levels and Birth Weight

Pardo, Inês Maria Crespo Gutierres; Geloneze, Bruno; Tambascia, Marcos Antônio; Barros-Filho, Antônio A.

doi:10.1038/oby.2004.59

Cited by 59 publications

(55 citation statements)

References 22 publications

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“…Previous studies have revealed conflicting results: some (25,28,29,31) found a positive association between ponderal index and adiopnectin, whereas others (20,30) showed no such relation. Hormonal factors, stress or gestational age may be responsible for the reported conflicting data (20, 25, 27 -31) but no previous study has performed multivariate adjustment to control for the potential effect of these potential confounders.…”

Section: Discussionmentioning

confidence: 85%

“…The strengths of this study include its relatively large size, which has provided the power needed to allow statistical documentation of important associations, the blinded measurements of hormone levels that minimizes misclassification, and the fact that this is the first study to perform multivariable adjustment for potential confounders such as gestational age, maternal factors and stress (28). While all previous studies have utilized cord blood, this research studied the above association using serum adiponectin levels of neonates.…”

Section: Discussionmentioning

confidence: 99%

“…It remains unclear why the gender difference is absent at birth and perhaps the gender dimorphism of adiponectin levels develops later in life in response to sex steroids in the peripubertal period (12,32,33). The role of gender with respect to adiponectin levels may prove to be of clinical importance, since it could also be directly related to gender differences in inflammatory responses and metabolic diseases later in life (28).…”

Section: Discussionmentioning

confidence: 99%

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Serum adiponectin concentrations in relation to maternaland perinatal characteristics in newborns

Mantzoros

Petridou

Alexe

et al. 2004

European Journal of Endocrinology

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Objective: To assess serum adiponectin levels of neonates in relation to ponderal index and birth length with and without adjustment for potential confounding factors including maternal factors and perinatal characteristics. Design: A cross-sectional study. Methods: Three hundred and three newborns (Caucasian, singleton, full term, with a birth weight of $ 2500 g, and apparently healthy) were included in the study. Blood samples were collected from the newborns no later than the fifth day of life for measurements of adiponectin and major IGF system components (IGF-I, IGF-II, IGF binding protein-3 (IGFBP-3)). The data were analyzed using simple and multiple regression analyses. Results: Adiponectin is substantially higher in neonates than in adults, with no evidence of the gender dimorphism observed among adults. We found an inverse association between neonatal adiponectin levels and newborn ponderal index and a positive association with newborn length by univariate analysis. We also found a statistically significant inverse association of adiponectin with jaundice/bilirubin, and a marginally significant positive association of this hormone with IGFBP-3 but no significant association with any maternal factors. In multivariate analysis, the inverse association between serum adiponectin and ponderal index does not remain significant after adjustment for potential confounding factors. In contrast, neonatal adiponectin levels correlate inversely significantly and independently with liver maturity and IGF-II and tend to remain positively associated with IGFBP-3 and increased birth length. Conclusions: An inverse association of adiponectin with ponderal index by univariate analysis is not independent from confounding factors. In contrast, the positive association between serum adiponectin and birth length may reflect either a direct effect of adiponectin or an adiponectin-mediated increase in the sensitivity of tissues to insulin and components of the IGF system, and needs to be explored further. European Journal of Endocrinology 151 741-746

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum adiponectin concentrations in relation to maternaland perinatal characteristics in newborns

Mantzoros

Petridou

Alexe

et al. 2004

European Journal of Endocrinology

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“…In addition to regulating body metabolism, adiponectin is also produced within the intrauterine environment (52,(103)(104)(105). The findings that adiponectin is present in cord blood (103), positively correlates with birth weight (52,104), and is highly produced by both the placenta and the fetus (52,105) suggest that this adipocytokine may play a key role in fetal growth, probably enhancing the growth-promoting effect of insulin through its insulin-sensitizing action (52).…”

Section: Adiponectin In Iugrmentioning

confidence: 97%

Intrauterine growth restriction and adult disease: the role of adipocytokines

Briana¹,

Malamitsi‐Puchner²

2009

European Journal of Endocrinology

126

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Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve his/her intrinsic growth potential, due to anatomical and/or functional disorders and diseases in the feto-placental-maternal unit. IUGR results in significant perinatal and long-term complications, including the development of insulin resistance/metabolic syndrome in adulthood.The thrifty phenotype hypothesis holds that intrauterine malnutrition leads to an adaptive response that alters the fetal metabolic and hormonal milieu designed for intrauterine survival. This fetal programming predisposes to an increased susceptibility for chronic diseases. Although the mechanisms controlling intrauterine growth are poorly understood, adipose tissue may play an important role in linking poor fetal growth to the subsequent development of adult diseases. Adipose tissue secretes a number of hormones, called adipocytokines, important in modulating metabolism and recently involved in intrauterine growth.This review aims to summarize reported findings concerning the role of adipocytokines (leptin, adiponectin, ghrelin, tumor necrosis factor (TNF), interleukin-6 (IL6), visfatin, resistin, apelin) in early life, while attempting to speculate mechanisms through which differential regulation of adipocytokines in IUGR may influence the risk for development of chronic diseases in later life.

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“…7 In contrast, in full-term neonates, during the first few days of life, serum or plasma adiponectin levels correlate positively with size at birth, neonatal adiposity and circulating levels of leptin. [8][9][10][11][12][13][14] It has been suggested that the factors implicated in adiponectin inhibition, which are mainly related to the amount/distribution of body fat, are not operative in newborns. 9 It has also been proposed that adiponectin has a role in fetal growth and development.…”

mentioning

confidence: 99%

Circulating levels of adiponectin in preterm infants

Siahanidou

Mandyla

Papassotiriou

et al. 2007

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Objective: To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels. Design: Prospective study. Setting: A university hospital neonatal care unit. Study population: 62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group). Interventions: Blood samples taken at discharge (40.9 (14.8) days of life) from the preterm infants and at a comparable postnatal age in full-term infants. All infants were fed the same commercial formula, but in nine preterms the formula contained long-chain polyunsaturated fatty acids (LCPUFAs). Main outcome measures: Serum levels of adiponectin, leptin and insulin. Associations of adiponectin levels were tested only in the preterm group. Results: Serum levels of adiponectin were lower in preterm (40.9 (14.8) mg/ml) than full-term infants (53.1 (16.0) mg/ml, p,0.01). However, after adjustment for body weight, the influence of prematurity on adiponectin levels was no longer significant. In preterm infants, adiponectin levels independently correlated with being born small for gestational age (SGA) (b = 20.35, p = 0.01), weight gain (b = 0.28, p = 0.03) and LCPUFA-supplemented formula (b = 0.34, p = 0.009). Serum adiponectin levels did not correlate with insulin or leptin levels. However, insulin levels were higher in preterm than in full-term infants after adjustment for body weight. Conclusions: Adiponectin levels are lower in preterm infants at discharge than full-term infants probably due to decreased adiposity. The levels are influenced by being born SGA, weight gain and, possibly, by dietary LCPUFAs. The importance of these findings in the development of insulin or leptin resistance in children born prematurely needs to be further studied. N utrition and growth during fetal life and early infancy have been linked to health and disease in later life.

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Hyperadiponectinemia in Newborns: Relationship with Leptin Levels and Birth Weight

Cited by 59 publications

References 22 publications

Serum adiponectin concentrations in relation to maternaland perinatal characteristics in newborns

Serum adiponectin concentrations in relation to maternaland perinatal characteristics in newborns

Intrauterine growth restriction and adult disease: the role of adipocytokines

Circulating levels of adiponectin in preterm infants

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