Hyperacute Rejection After Single Lung Transplantation: A Case Report

Camargo, Jesus; Camargo, Spencer Marcantônio; Schio, Sadi Marcelo; Machuca, Tiago; Perin, Fabíola Adélia

doi:10.1016/j.transproceed.2008.02.052

Cited by 25 publications

(10 citation statements)

References 7 publications

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“…In most of the documented cases hyperacute rejection was caused by pre-existing donor-specific HLA Class I antibodies. 7,[9][10][11] Three studies reported (hyper)acute rejection due to donor-specific Class II antibodies. 5,23,24 A recent case report showed hyperacute rejection due to antibodies against DQA1 molecules leading to transplant failure and death of the patient, indicating that anti-DQ antibodies can be damaging to a lung allograft.…”

Section: Discussionmentioning

confidence: 99%

Successful lung transplantation in the presence of pre-existing donor-specific cytotoxic HLA Class II antibodies

Lambeck¹,

Verschuuren²,

Bouwman³

et al. 2012

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Successful lung transplantation in the presence of pre-existing donor-specific cytotoxic HLA Class II antibodies

Lambeck¹,

Verschuuren²,

Bouwman³

et al. 2012

The Journal of Heart and Lung Transplantation

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Section: Hyperacute Rejectionmentioning

confidence: 99%

“…Histologically, platelet thrombi, neutrophilic infiltration, fibrin thrombi, necrosis of vessel wall, and morphologic features of diffuse alveolar damage (DAD) have been described [15]. Autopsy findings include red hepatization and firm consistency of the transplanted lung with microscopic evidence of acute lung injury [15]. [10] (Table 1) The ISHLT consensus classification for lung allograft rejection was developed as a "working formulation" for the diagnosis of lung rejection by transbronchial biopsy [16].…”

Section: Hyperacute Rejectionmentioning

confidence: 99%

The Pathology of Lung Allograft Rejection: A Concise Review

Roden¹,

Tazelaar²

2012

Tur Toraks Der

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Lung transplantations in humans have been performed for almost 50 years. However, allograft rejection, non-rejection diseases such as harvest/reperfusion injury, infection, drug toxicity, post-transplant lymphoproliferative diseases, and recurrent disease are still significant complications. Although the clinical impression might suggest the possibility of any of these conditions, tissue diagnosis is usually necessary to establish a definitive diagnosis. This article mainly focuses on reviewing the morphological features of lung allograft rejection and its grading according to the revised 2007 ISHLT consensus classification of allograft rejection. Acute and chronic alloreactive injuries affect both the vasculature and the airways. Currently, the guidelines of the 2007 ISHLT consensus conference are used for the histolopathologic assessment of rejection. Although antibody mediated rejection is recognized in heart and kidney transplants, at present, there is no consensus about its diagnosis in transplanted lungs. Mimickers of rejection and posttransplant diseases will also be discussed. The collaboration between the transplant clinician and pathologist cannot be overemphasized to establish an optimal treatment for the individual patient following lung transplantation. (

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“…Further investigation detected an anti-HLA A2 in the recipient serum, and the donor had an A2 antigen. 11 The tools are important.…”

Section: Hyperacute Rejectionmentioning

confidence: 99%