Hyperacusis following unilateral damage to the insular cortex: A three-case report

Boucher, Olivier; Turgeon, Christine; Champoux, Sara; Ménard, Lucie; Rouleau, Isabelle; Lassonde, Maryse; Leporé, Franco; Nguyen, Dang Khoa

doi:10.1016/j.brainres.2015.02.030

Cited by 32 publications

(34 citation statements)

References 60 publications

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“…MMN responses, and their source locations, were negatively related to emotional-cognitive distress caused by tinnitus. In the study by Boucher et al 44,. no significant effect on P2 or MMN amplitude was found in hyperacusis caused by insular lesion.…”

Section: Discussionmentioning

confidence: 94%

A window into the brain mechanisms associated with noise sensitivity

Kliuchko

Heinonen-Guzejev

Vuust

et al. 2016

Sci Rep

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Noise sensitive individuals are more likely to experience negative emotions from unwanted sounds and they show greater susceptibility to adverse effects of noise on health. Noise sensitivity does not originate from dysfunctions of the peripheral auditory system, and it is thus far unknown whether and how it relates to abnormalities of auditory processing in the central nervous system. We conducted a combined electroencephalography and magnetoencephalography (M/EEG) study to measure neural sound feature processing in the central auditory system in relation to the individual noise sensitivity. Our results show that high noise sensitivity is associated with altered sound feature encoding and attenuated discrimination of sound noisiness in the auditory cortex. This finding makes a step towards objective measures of noise sensitivity instead of self-evaluation questionnaires and the development of strategies to prevent negative effects of noise on the susceptible population.

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Section: Discussionmentioning

confidence: 94%

A window into the brain mechanisms associated with noise sensitivity

Kliuchko

Heinonen-Guzejev

Vuust

et al. 2016

Sci Rep

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“…The posterior insula is also thought to play a fundamental role in pain perception, showing consistent activation in response to noxious stimuli in neuroimaging studies, irrelevant of modality or body part 39, 40 . Interestingly, strokes and cortical resections involving the posterior insula and the innermost parietal operculum have been associated with a central pain syndrome with dissociated contralateral thermoalgesic sensory loss 41 , suggesting an intimate relation between the thermal and nociceptive functions of the insula.…”

Section: Insula Functionmentioning

confidence: 99%

Structure and Function of the Human Insula

Uddin

Nomi

Hébert-Seropian

et al. 2017

Journal of Clinical Neurophysiology

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811

604

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The insular cortex, or “Island of Reil”, is hidden deep within the lateral sulcus of the brain. Subdivisions within the insula have been identified on the basis of cytoarchitectonics, sulcal landmarks, and connectivity. Depending on the parcellation technique employed, the insula can be divided into anywhere between 2 and 13 distinct subdivisions. The insula subserves a wide variety of functions in humans ranging from sensory and affective processing to high-level cognition. Here we provide a concise summary of known structural and functional features of the human insular cortex with a focus on lesion case studies and recent neuroimaging evidence for considerable functional heterogeneity of this brain region.

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“…Other terminology that is used in this regard includes “decreased” or “reduced sound tolerance”: An Internet patient forum ( www.hyperacusis.net [ 23 ]) uses the variant “collapsed sound tolerance.” While there is undoubtedly an emotional and psychological component to hyperacusis [ 25 ] (not least since becoming apprehensive about sound exposure is an obvious corollary to perceiving that sound as intense), hyperacusis is a subjective self-reported symptom of some physiological change in the central auditory system such as increased gain [ 3 ], such that even when sound is of a moderate intensity it is perceived as loud and intrusive. Hyperacusis is almost exclusively bilateral, and the presentation of unilateral hyperacusis is confined to unilateral triggers such as an acoustic shock [ 30 ] or a specific unilateral neural lesion [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Hyperacusis: major research questions

Baguley

Hoare

2018

HNO

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BackgroundHyperacusis is a troublesome symptom that can have a marked negative impact on quality of life.ObjectivesTo identify major research questions in hyperacusis.Materials and methodsReview of gaps in knowledge regarding hyperacusis, and where opportunities may lie to address these.ResultsEight major research questions were identified as priorities for future research. These were: What is the prevalence of hyperacusis in adults and children? What are the risk factors associated with hyperacusis? What is the natural history of hyperacusis? How is ‘pain hyperacusis’ perceived? What mechanisms are involved in hyperacusis? What is the relationship between hyperacusis and tinnitus? Can a questionnaire be developed that accurately measures the impact of hyperacusis and can be used as a treatment outcome measure? What treatments, alone or in combination, are effective for hyperacusis?ConclusionThis clinical/researcher-led project identified major research questions in hyperacusis. A further development to identify patient-prioritized research will follow.

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Hyperacusis following unilateral damage to the insular cortex: A three-case report

Cited by 32 publications

References 60 publications

A window into the brain mechanisms associated with noise sensitivity

A window into the brain mechanisms associated with noise sensitivity

Structure and Function of the Human Insula

Hyperacusis: major research questions

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