Abstract:Controversy still exists about the exact role of platelets in the pathogenesis of atherosclerosis. However, patients with cardiovascular (CV) diseases have been reported to have enhanced platelet activity and to show hyperaggregability in response to common aggregators. Very little is known on 5-hydroxytryptamine (5-HT)-induced platelet aggregation in these patients. In a previous preliminary study we observed an increased sensitivity of platelets in response to 5-HT in patients with CV diseases. We further sh… Show more
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