Hyperactivity Induced By Vapor Inhalation of Nicotine in Male and Female Rats
Mehrak Javadi-Paydar,
Tony M. Kerr,
Michael A. Taffe
Abstract:RationalePreclinical models of electronic nicotine delivery system (ENDS; “e-cigarette”) use have been rare, so there is an urgent need to develop experimental approaches to evaluate their effects.ObjectiveTo contrast the impact of inhaled nicotine across sex.MethodsMale and female Wistar rats were exposed to vapor from a propylene glycol vehicle (PG), nicotine (NIC; 1-30 mg/mL in PG), or were injected with NIC (0.1-0.8 mg/kg, s.c.), and then assessed for changes in temperature and activity. The antagonist mec… Show more
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