Hyper-fractionated Intensity Modulated Radiation Therapy (HF-IMRT) in Head and Neck Cancer: The Technical Feasibility and Results of a Short Clinical Series

Balukrishna, Sasidharan; Pilaka, Venkata Krishna Reddy; Michael, Rajiv C; Samuel, Prasanna; Ravindran, P

doi:10.7860/jcdr/2015/11343.5878

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…HRT and IMRT are also being increasingly used together in HNC RT regimens. Small scale studies thus far have found HRT-IMRT to be well tolerated with marginally improved locoregional control in patients with locally advanced HNC [18][19][20]. Given the recent incorporation of HRT and IMRT into HNC treatment, more research is needed to determine factors affecting treatment selection, prognosis and survival associated with these forms of therapy.…”

Section: Introductionmentioning

confidence: 99%

Treatment trends in head and neck cancer: Surveillance, Epidemiology, and End Results (SEER) Patterns of Care analysis

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Pagedar

Chioreso

et al. 2019

Cancer Causes Control

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Purpose-Recent advances in head and neck cancer (HNC) treatment, such as increased use of organ-preserving advanced radiation treatments, the approval of cetuximab for HNC treatment, and the increase in human papillomavirus (HPV)-related HNC, have changed clinical approaches to HNC management. We sought to identify treatment trends in a population-based cohort of HNC patients. Methods-The Surveillance, Epidemiology, and End Results Patterns of Care program collected additional treatment and HPV testing information on stratified random samples of HNC patients diagnosed in 1997 (n=473), 2004 (n=1,317), and 2009 (n=1,128). Rao-Scott chi-square tests were used to examine unadjusted associations between year of diagnosis and patient sociodemographic, tumor, and treatment characteristics. Cochran-Armitage tests for trend were used to examine the hypothesis that certain treatments were used increasingly (or decreasingly) over the time period, while logistic regression was used to examine factors associated with particular treatments. Results-Use of radiation and chemotherapy without surgery significantly increased for all HNC sites between 1997 and 2009. Cetuximab and taxane use also showed a significantly increasing trend. Lack of insurance was associated with not receiving treatment in multivariate models. The majority (64%) of cases undergoing radiation in 2009 received an advanced treatment, with 55% receiving intensity modulated. The majority of oropharyngeal cases with known HPV status received chemotherapy and radiation only (62%) and nearly all were insured and had one or fewer co-morbidities. Conclusions-Treatment patterns have changed for HNC, leading to increased incorporation of systemic therapy and newer radiation techniques. HPV testing should be targeted for more widespread use, especially in traditionally underserved groups.

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Section: Introductionmentioning

confidence: 99%

Treatment trends in head and neck cancer: Surveillance, Epidemiology, and End Results (SEER) Patterns of Care analysis

Schlichting

Pagedar

Chioreso

et al. 2019

Cancer Causes Control

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“…As a matter of fact, RTOG 9003 11 has reported that hyperfractionation and accelerated fractionation with concomitant boost are more efficacious than standard fractionation for locally advanced head and neck cancer. Balukrishna et al 12 reported a series of 3 patients with advanced oropharyngeal cancers who were treated with hyperfractionated-IMRT. Two phase treatment planning were adopted with phase I prescribed to high risk volume and intermediate risk volume, 60 Gy in 50 fractions at 1.2 Gy per fraction, 2 fractions/day, 6 to 8 hours apart.…”

Section: Discussionmentioning

confidence: 99%

Late-course accelerated hyperfractionated intensity-modulated radiotherapy for nasopharyngeal adenoid cystic carcinoma: A case report

Xie

Chen

et al. 2020

Medical Dosimetry

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“…The super-segmented IMRT has also been put forward, it combines the advantages of super-grading with those of IMRT. The study of Monnerat et al ( 16 ) showed the feasibility of this regimen, but stage II tests are still needed to validate its efficacy ( 19 ). The assessment of survival and adverse reactions was limited by only using the criteria of the World Health Organization (WHO), Response Evaluation Criteria In Solid Tumors (RECIST) and RECIST 1.1, especially when assessing the efficacy of newer cancer treatments.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and survival rate of intensity-modulated radiotherapy combined with chemotherapy for elderly patients with locally advanced oropharyngeal cancer

Lin

2017

Exp Ther Med

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Abstract. The efficacy of intensity-modulated radiotherapy (IMRT) combined with chemotherapy in the treatment of elderly patients with locally advanced oropharyngeal cancer and its effect on survival rate were studied. Elderly patients (n=150) diagnosed with locally advanced oropharyngeal cancer by histopathology were selected and randomly divided into the observation group (n=75) and the control group (n=75). Patients in the observation group were treated with IMRT combined with chemotherapy, while those in the control group were treated with conventional radiotherapy and chemotherapy. The two groups were treated with docetaxel + cisplatin (TP regimen). All patients received 1 to 2 cycles of docetaxel + cisplatin-induced chemotherapy, and after the radiotherapy began, the chemotherapy with docetaxel was synchronously conducted. The recent efficacy (tumor regression condition was observed at 3 months after the treatment), 1-year, 3-year and 5-year overall survival (OS), local-regional control (LRC), progression-free survival (PFS), disease-free survival (DFS) and the incidence rate of adverse reactions of patients in the two groups were compared. In the observation group, 73 patients completed the radiotherapy and chemotherapy, while all the patients in the control group completed the treatments. The 1-year OS of the observation group and the control group was 97.3 and 85.3%, respectively. In the observation group, the 3-year LRC, OS, PFS and DFS of the observation group was 94.5, 91.8, 90.4 and 87.7%, respectively; the 5-year LRC, OS, PFS and DFS was 64.4, 56.2, 56.2 and 54.8%, respectively. In the control group, the 3-year LRC, OS, PFS and DFS was 86.7, 73.3, 82.7 and 68.0%, respectively; the 5-year LRC, OS, PFS and DFS were 54.7, 45.3, 44.0 and 56.7%, respectively. The differences were statistically significant (P<0.05). In the observation group, the number of leukocytes was decreased, and the incidence rates of acute oropharyngeal mucosa reaction and radiation dermatitis were significantly lower than those in the control group. The differences were statistically significant (P<0.05). In conclusion, IMRT combined with chemotherapy can improve the OS and the 3-year and 5-year LRC, PFS and DFS of elderly patients with locally advanced oropharyngeal cancer, reduce toxic and side effects, and improve patients' quality of life. IntroductionIn recent years, oropharyngeal cancer has accounted for ~1.3% of systemic malignant tumors and 4.2% of head and neck cancers. With the changes in people's eating habits and gradually increased pressure, the incidence rate continues to rise. The disease often occurs in men, especially in those aged 50-60 years or alcoholics. In addition, betel nut, human papillomavirus infection and other factors are related to the occurrence of oral cancer to a certain degree (1). At present, if the locally advanced oral cancer is only treated by surgical treatments, the specificity of its anatomical location and strong invasion will bring great difficulties to the operation, which not only caus...

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Hyper-fractionated Intensity Modulated Radiation Therapy (HF-IMRT) in Head and Neck Cancer: The Technical Feasibility and Results of a Short Clinical Series

Cited by 3 publications

References 7 publications

Treatment trends in head and neck cancer: Surveillance, Epidemiology, and End Results (SEER) Patterns of Care analysis

Treatment trends in head and neck cancer: Surveillance, Epidemiology, and End Results (SEER) Patterns of Care analysis

Late-course accelerated hyperfractionated intensity-modulated radiotherapy for nasopharyngeal adenoid cystic carcinoma: A case report

Efficacy and survival rate of intensity-modulated radiotherapy combined with chemotherapy for elderly patients with locally advanced oropharyngeal cancer

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