Hyper‐Crosslinkers Lead to Temperature‐ and pH‐Responsive Polymeric Nanogels with Unusual Volume Change

Zhou, Ning; Cao, Xiaoyan; Du, Xuewen; Wang, Huaimin; Wang, Ming; Liu, Shuang; Nguyen, Khang Cao; Schmidt‐Rohr, Klaus; Xu, Qiaobing; Liang, Gaolin; Xu, Bing

doi:10.1002/anie.201611479

Cited by 24 publications

(10 citation statements)

References 50 publications

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“…However, it still somewhat suffers from severe systemic toxic side effects and inevitable drug resistance that limits the therapeutic efficiency . Stimuli-responsive nanocarriers of drugs, which can respond to endogenous stimuli (such as pH, , enzyme, , ion, , and redox potential , ) and/or exogenous stimuli (such as temperature, − light, , magnetic field, , and ultrasound), have great potential to overcome the abovementioned limitations of conventional chemotherapy. However, stimuli-responsive nanocarrier-mediated single-modal chemotherapy remains undesirable due to the complexity and variability of the tumor microenvironment .…”

Section: Introductionmentioning

confidence: 99%

Novel Multifunctional Stimuli-Responsive Nanoparticles for Synergetic Chemo–Photothermal Therapy of Tumors

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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In this study, a novel class of multifunctional responsive nanoparticles is designed and fabricated as drug nanocarriers for synergetic chemo–photothermal therapy of tumors. The proposed nanoparticles are composed of a thermo-/pH-responsive poly(N-isopropylacrylamide-co-acrylic acid) (PNA) nanogel core, a polydopamine (PDA) layer for photothermal conversion, and an outer folic acid (FA) layer as a targeting agent for the folate receptors on tumor cells. The fabricated nanoparticles show good biocompatibility and outstanding photothermal conversion efficiency. The proposed nanoparticles loaded with doxorubicin (DOX) drug molecules are stable under physiological conditions with low leakage of drugs, while rapidly release drugs in environments with low pH conditions and at high temperature. The experimental results show that the drug release process is mainly governed by Fickian diffusion. In vitro cell experimental results demonstrate that the PNA–DOX@PDA–FA nanoparticles can be phagocytized by 4T1 tumor cells and release drugs in tumor cell acidic environments, and confirm that the combined chemo and photothermal therapeutic efficacy of PNA–DOX@PDA–FA nanoparticles is higher than the photothermal therapeutic efficacy or the chemotherapeutic efficacy alone. The proposed multifunctional responsive nanoparticles in this study provide a novel class of drug nanocarriers as a promising tool for synergetic chemo–photothermal therapy of tumors.

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Section: Introductionmentioning

confidence: 99%

Novel Multifunctional Stimuli-Responsive Nanoparticles for Synergetic Chemo–Photothermal Therapy of Tumors

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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“…15 As a consequence of these unique structure-dependent properties, hydrogels can efficiently remove metal ions from wastewater. 16,17 The desired hydrogel properties can be modified by controlling the synthesis parameters, such as reactor type, reaction temperature, reaction time, and polymerization molecular network structure. 18,19 In addition, depending on the heavy metal ions to be removed, specifically functionalized hydrogels can be prepared.…”

Section: Introductionmentioning

confidence: 99%

Cu(II) and Cd(II) capture using novel thermosensitive hydrogel microspheres: adsorption behavior study and mechanism investigation

Tang

Huang

Tun

et al. 2021

J of Chemical Tech & Biotech

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BACKGROUND: At present, various kinds of hydrogel adsorbents are applied to the treatment of heavy metal ions in wastewater. In this work, we focused on the adsorption of cadmium [Cd(II)] and copper [Cu(II)] onto microspheres of a novel thermosensitive hydrogel (NH 2 -SA/PNIPA, aminated sodium alginate/poly-N-isopropyl acrylamide), studied the effect of temperature on the phase transition of the hydrogel in detail, and discussed the influence on the adsorption behavior of metal ions in the hydrogel. RESULTS:The NH 2 -SA/PNIPA exhibited a higher adsorption efficiency under the conditions of interfering monovalent cationic and neutral pH. The adsorption capacities based on the Langmuir model were 57.2 mg g -1 for Cu(II) and 100.5 mg g -1 for Cd(II) at 20°C, respectively. Higher temperature facilitated the adsorption process and also led to the volume shrinkage and hydrophobicity of NH 2 -SA/PNIPA. The metal ions had different hydration and hence different adsorption capacities, of 56.7 mg g -1 for Cu(II) and 88.6 mg g -1 for Cd(II) at 40°C. The results of diffusion behavior analysis showed that the diffusion coefficients were ≈1 × 10 −11 m 2 s -1 . The adsorption performance of NH 2 -SA/PNIPA hardly decreased even after five cycles. In addition, the adsorption process was controlled mainly by the complexation reaction. CONCLUSION:The novel hydrogel microspheres overcame the deficiency of conventional adsorbents and possessed high diffusibility. This work provides a theoretical basis and empirical evidence for enhancement of adsorbents for removing heavy metals in wastewater.

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“…Inspired by biological actuators, mankind has developed responsive soft material systems that can perform animal‐like shape morphing upon different stimuli, such as light, [ 8,9 ] heat, [ 10 ] pH, [ 11 ] magnetism, [ 12,13 ] electricity, [ 14 ] etc. The stimuli‐driven active forces produced by these materials resemble the biological muscles driven by chemical fuels.…”

Section: Introductionmentioning

confidence: 99%

“…[4,5] Snapping motion enables ultrafast reactions in the time scales of milliseconds or below, yielding extraordinary survival skills for normally slow-moving species, equipping them with, e.g., fast preying, escaping, or seed-spreading capabilities. [3,6,7] Inspired by biological actuators, mankind has developed responsive soft material systems that can perform animal-like shape morphing upon different stimuli, such as light, [8,9] heat, [10] pH, [11] magnetism, [12,13] electricity, [14] etc. The stimuli-driven active forces produced by these materials resemble the biological muscles driven by chemical fuels.…”

mentioning

confidence: 99%

Optically Controlled Latching and Launching in Soft Actuators

Guo

Priimägi

Zeng

2021

Adv Funct Materials

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Snapping is an abrupt reaction, in which mechanical instability allows the structure to rapidly switch from one stabilized form to another. Snapping is attained through a sudden release of prestored elastic energy. It is perfected by natural species to enhance their preying, locomotion, and reproduction abilities. Recent developments in responsive materials research has allowed the realization of bioinspired snappers and rapidly moving soft robots triggered by external stimuli. However, it remains a grand challenge to reversibly and accurately control the snapping dynamics in terms of, e.g., onset timing and speed of motion. Here, a facile method to obtain light‐fueled snapping‐like launching with precise control over the elastic energy released and the onset timing is reported. The elastic energy is prestored in a light‐responsive liquid crystal elastomer actuator, and the launching event is dictated by releasing the energy through a photothermally induced crystal‐to‐liquid transition of a liquid‐crystalline adhesive latch. The method provides manual control over the amount of prestored energy, motion speed upon multiple launching events, and enables demonstrations such as jumping and catapult motions in soft robots and concerted motions of multiple launchers. The results provide a practical solution for controlled fast motions in soft small‐scale robotics.

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Hyper‐Crosslinkers Lead to Temperature‐ and pH‐Responsive Polymeric Nanogels with Unusual Volume Change

Cited by 24 publications

References 50 publications

Novel Multifunctional Stimuli-Responsive Nanoparticles for Synergetic Chemo–Photothermal Therapy of Tumors

Novel Multifunctional Stimuli-Responsive Nanoparticles for Synergetic Chemo–Photothermal Therapy of Tumors

Cu(II) and Cd(II) capture using novel thermosensitive hydrogel microspheres: adsorption behavior study and mechanism investigation

Optically Controlled Latching and Launching in Soft Actuators

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