Hyper-brain connectivity in binge drinking college students: a diffusion tensor imaging study

Kashfi, Karl; Al-Khalil, Kareem; Hou, Jiancheng; Fang, Dan; Anderson, Ron; Rajmohan, Ravi; Syapin, Peter J.; O’Boyle, Michael W.

doi:10.1080/13554794.2017.1347264

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…FA, which quantifies the directionality of diffusion within a voxel between 0 (undirected, isotropic) and 1 (directed, anisotropic), is derived from the diffusion tensor and is the most commonly studied diffusion parameter of white matter microstructural properties related to the integrity of the fiber tract 21,22 . Increased (or decreased) FA in white matter tracts involved in cognitive processes is related to improved (or declined) cognitive function 7,23 , but the reduced FA in white matter tracts related to affective processes is related to increased severity of depression, anxiety or stress [24][25][26] . In the current study, the decreased FA on the bilateral C(cg) in CDs' may indicate increased severity of depression or anxiety (the C(cg) is responsible for pain, depression, mood, and anxiety perceptions 16,[27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Hou

Dodd

Nair

et al. 2020

Sci Rep

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Patients with inflammatory bowel disease have been shown to have abnormal brain morphometry or function, which are associated with psychological symptoms such as stress, depression or anxiety. The present work recruited 20 Crohn's disease patients in remission (CDs) and 20 age-gender-handednesseducation matched healthy controls (HCs) and compared their brain white matter microstructural properties using Diffusion Tensor Imaging (DTI). Additionally, we examined the correlations between the microstructural properties and cognition (verbal fluency language task, VF) and affect (anxiety) in both groups as well as disease duration in CDs. Results showed that CDs exhibited significant alterations in microstructural properties compared to Hcs in various white matter tracts relevant to language function despite no significant difference in VF scores. Furthermore, CDs' microstructural changes exhibited correlations with anxiety level and disease duration. These findings suggest that CD patients may experience changes in white matter microstructural properties which may be a biomarker of neuropsychiatric comorbidities of CD.Crohn's disease (CD), as one subtype of inflammatory bowel disease (IBD), is thought to be caused by disruption of the normal immune system and also perhaps by altered intestinal permeability 1 and it can affect any gastrointestinal part from the mouth to the anus 2 . The impact of IBD may also extend to the brain and lead to anatomical and functional changes. Several studies have reported anatomical and functional brain changes in CD patients, possibly due to increased proinflammatory cytokines or chemokines and microglial cells which play an important role in communication between the brain, gut, and systemic immune system. These systemic changes have been posited to lead to a cascade of neuroplastic events that result in anatomical or functional brain changes that affect cognitive or affective abilities 3-5 . The observed brain changes might also account for the increased sensitivity of the CD patients to their related external environment which has been described among CDs and the inadequate ability to modulate cognitive and emotional states 3,6,7 . Moreover, the comorbidities assciated with IBD such as psychological stress, anxiety, depression, chronic pain may also influence anatomical and functional changes in the brain 1 .A growing body of evidence suggests that abnormalities in the brain morphometry or function of CD patients may correlate with cognitive and affective changes. Several studies, in CD patients, have reported changes in brian morphometry compared to age-matched healthy controls (HCs). For exmaple, Bao et al. reported decreased cortical thickness in several regions and this decrease was correlated to pain score or disease duration 8 . Increased cortical thickness has also been reported as well as decreased sub-cortical volumes have been correlated to pain score or disease duration 3 ; Zikou et al. showed decreased volume in the bilateral fusiform, inferior temporal gyrus (emotional...

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Section: Discussionmentioning

confidence: 99%

Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Hou

Dodd

Nair

et al. 2020

Sci Rep

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“…All diffusion data were processed using the “Pipeline for Analyzing braiN Diffusion images” (PANDA): a toolbox implemented in MATLAB 1 ( Cui et al, 2013 ). This software employs several neuroimaging processing modules, namely, the FMRIB Software Library (FSL), the Pipeline System for Octave and Matlab (PSOM), the Diffusion Toolkit, and the MRIcron to automatically perform a series of steps (i.e., skull removal, correction of eddy current distortion, build diffusion tensor models) ( Cui et al, 2013 ; Kashfi et al, 2017 ; Hou et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults

Yeske

Hou

Adluru

et al. 2021

Front. Aging Neurosci.

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Throughout adulthood, the brain undergoes an array of structural and functional changes during the typical aging process. These changes involve decreased brain volume, reduced synaptic density, and alterations in white matter (WM). Although there have been some previous neuroimaging studies that have measured the ability of adult language production and its correlations to brain function, structural gray matter volume, and functional differences between young and old adults, the structural role of WM in adult language production in individuals across the life span remains to be thoroughly elucidated. This study selected 38 young adults and 35 old adults for diffusion tensor imaging (DTI) and performed the Controlled Oral Word Association Test to assess verbal fluency (VF). Tract-Based Spatial Statistics were employed to evaluate the voxel-based group differences of diffusion metrics for the values of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and local diffusion homogeneity (LDH) in 12 WM regions of interest associated with language production. To investigate group differences on each DTI metric, an analysis of covariance (ANCOVA) controlling for sex and education level was performed, and the statistical threshold was considered at p < 0.00083 (0.05/60 labels) after Bonferroni correction for multiple comparisons. Significant differences in DTI metrics identified in the ANCOVA were used to perform correlation analyses with VF scores. Compared to the old adults, the young adults had significantly (1) increased FA values on the bilateral anterior corona radiata (ACR); (2) decreased MD values on the right ACR, but increased MD on the left uncinate fasciculus (UF); and (3) decreased RD on the bilateral ACR. There were no significant differences between the groups for AD or LDH. Moreover, the old adults had only a significant correlation between the VF score and the MD on the left UF. There were no significant correlations between VF score and DTI metrics in the young adults. This study adds to the growing body of research that WM areas involved in language production are sensitive to aging.

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“…The observed radial and mean diffusivity reduction can result from the extracellular matrix reorganization with increased tissue density [ 48 ]. Some studies have also reported a binge-drinking-associated increase in brain connectivity and FA of the cingulum (the area which is often associated with reward and positive reinforcement), in the corona radiata and capsula [ 60 – 62 ], or increase in the neurite density in the cortical white matter [ 63 ]. Such observed brain hyperconnectivity might place these individuals at higher risk of impulsive behavior, including binge drinking.…”

Section: Neuroimaging Neurocognitive and Neurophysiological Studmentioning

confidence: 99%

Neurobiological Effects of Binge Drinking Help in Its Detection and Differential Diagnosis from Alcohol Dependence

et al. 2018

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The prevalence of binge drinking in the general population is 3-4 times higher than that of alcohol dependence. Neuroimaging studies show that binge drinking in adolescence impairs brain development and white matter integrity. Regions with reduced functional activity include the limbic system, ventral diencephalon, frontal lobe, and middle and inferior temporal lobes, whereas the right superior frontal and parietal lobes are typically hyperactivated. The observed activation of the frontoparietal areas might reflect the alternative memory system operating, whereas the reduced occipito-hippocampal response is associated with impaired visual and linguistic processing/learning. Some other findings from literature research include a decrease of N-acetylaspartate (NAA) in the frontal lobe and its increase in the parietal lobes, as well as the reduced components of event-related potentials, reflecting deficit in attention, working memory, inhibition, and executive functioning. Animal studies show that even a single day of binge drinking results in a neurodegeneration and reactive gliosis in the limbic cortex as well as in gene expression dysregulation and histone acetylation. Another biological evidence on binge drinking effect include inflammatory response, oxidative stress, formation of toxic ceramides, activation of caspase 3, and secretion of corticoliberin. Some of the binge drinking-induced cognitive abnormalities can be reversible after three weeks of abstinence. Although binge drinkers have a similar pattern of neuropsychological deficits with chronic alcohol consumers (mainly memory deficits), binge drinkers have prominent impairment of inhibitory control, which may be a marker of binge pattern of alcohol drinking. The optimal therapeutic strategies should target the inhibitory control processes to facilitate discontinuation of alcohol consumption and to block its possible progression to the alcohol dependence syndrome.

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Hyper-brain connectivity in binge drinking college students: a diffusion tensor imaging study

Cited by 6 publications

References 47 publications

Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Alterations in brain white matter microstructural properties in patients with Crohn’s disease in remission

Differences in Diffusion Tensor Imaging White Matter Integrity Related to Verbal Fluency Between Young and Old Adults

Neurobiological Effects of Binge Drinking Help in Its Detection and Differential Diagnosis from Alcohol Dependence

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