Hyoscine butylbromide administered at the cecum increases polyp detection: a randomized double-blind placebo-controlled trial

Corte, Crispin; Dahlenburg, L.; Selby, Warwick; Griffin, Sean; Byrne, Christopher; Chua, Tee Joo; Kaffes, Arthur J.

doi:10.1055/s-0032-1310009

Cited by 49 publications

(69 citation statements)

References 29 publications

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“…(Figure 1). Of these articles, 8 published randomized controlled trials (RCTs) performed at various locations in Europe, Asia, and Australia were included in our meta- analysis, seven published as manuscripts [17,[25][26][27][28][29][30] and one published as an abstract [24] ( Table 1). All included patients with a hyoscine and a no hyoscine/placebo group and were of acceptable quality (≥ 2 on the Jadad scale) ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…They did not notice any difference between the sites of polyps and suggested that hyoscine might be an option in patients with significant spasm [17] . Similarly, Corte et al [25] favored the use of hyoscine for screening and surveillance colonoscopy to aid in polyp detection. They did notice a difference in the withdrawal time and attributed that likely to the time spent on waiting for the spasm to resolve [25] .…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Corte et al [25] favored the use of hyoscine for screening and surveillance colonoscopy to aid in polyp detection. They did notice a difference in the withdrawal time and attributed that likely to the time spent on waiting for the spasm to resolve [25] . However, this was not designed primarily for ADR and considered…”

Section: Discussionmentioning

confidence: 99%

“…It is associated with significantly less anticholinergic side effects due to not crossing the blood-brain barrier, making it a useful antispasmodic agent [23] . The use of hyoscine as premedication or at the time of cecal intubation during colonoscopy has shown conflicting results for detection of polyps [17,[24][25][26][27][28][29][30] . Therefore, through study of randomized controlled trials (RCTs), hyoscine was compared to no hyoscine or placebo for polyp or adenoma detection during colonoscopy.…”

Section: Introductionmentioning

confidence: 99%

“…November 16, 2014|Volume 6|Issue 11| WJGE|www.wjgnet.com [26] 2012 RCT Double Netherlands 674 20 mg IV Cecal intubation Byun et al [24] 2009 RCT Double NR 205 20 mg IV Cecal intubation Lee et al [17] 2010 RCT Double NR 116 20 mg IV Cecal intubation Kim et al [27] 2010 RCT Double South Korea 133 20 mg IM Premedication Rondonotti et al [29] 2013 RCT Double Italy 402 20 mg IV Cecal intubation Mui et al [28] 2004 RCT Yes China 120 40 mg IV Premedication Saunders et al [30] 1996 RCT Yes England 56 20 mg IV Premedication Corte et al [25] 2012 RCT Yes Australia 601 20 mg IV Cecal intubation RCT: Randomized controlled trial; NR: Not reported. tachycardia with hyoscine.…”

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confidence: 99%

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Hyoscine for polyp detection during colonoscopy: A meta-analysis and systematic review

Ashraf

Siddique

et al. 2014

WJGE

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AIM:To assess the role of hyoscine for polyp detection during colonoscopy. METHODS: Studies (randomized controlled trials orRCTs) that compared the use of hyoscine vs no hyoscine or placebo for polyp detection during colonoscopy were included in our analysis. A search on multiple databases was performed in September 2013 with search terms being "hyoscine and colonoscopy", "hyoscine and polyp", "hyoscine and adenoma", "antispasmotic and colonoscopy", "antispasmotic and adenoma", and "antispasmotic and polyp". Jadad scoring was used to assess the quality of studies. The efficacy of hyoscine was analyzed using Mantel-Haenszel model for polyp and adenoma detection with odds ratio (OR). The I 2 measure of inconsistency was used to assess heterogeneity (P < 0.05 or I 2 > 50%). Statistical analysis was performed by RevMan 5.1. Funnel plots was used to assess publication bias. RESULTS:The search of the electronic databases identified 283 articles. Of these articles, eight published RCTs performed at various locations in Europe, Asia, and Australia were included in our meta-analysis, seven published as manuscripts and one published as an abstract (n = 2307). All the studies included patients with a hyoscine and a no hyoscine/placebo group and were of adequate quality (Jadad score ≥ 2). Eight RCTs assessed the polyp detection rate (PDR) (n = 2307). The use of hyoscine demonstrated no statistically significant difference as compared to no hyoscine or placebo for PDR (OR = 1.06; 95%CI: 0.89-1.25; P = 0.51). FiveRCTs assessed the adenoma detection rate (ADR) (n = 2015). The use of hyoscine demonstrated no statistically significant difference as compared to no hyoscine or placebo for ADR (OR = 1.12; 95%CI: 0.92-1.37; P = 0.25). Furthermore, the timing of hyoscine administration (given at cecal intubation or pre-procedure) demonstrated no differences in PDR compared to no hyoscine or placebo. Publication bias or heterogeneity was not observed for any of the outcomes. CONCLUSION:Hyoscine use in patients undergoing colonoscopy does not appear to significantly increase the detection of polyps or adenomas.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Hyoscine; Antispasmodic; Polyp detection; Colonoscopy Core tip: Hyoscine is used in clinical practice to decrease spasms in the colon during colonoscopy in an effort to improve polyp or adenoma detection. However, this study shows that hyoscine given before the procedure or at time of cecal intubation does not improve polyp or adenoma detection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hyoscine for polyp detection during colonoscopy: A meta-analysis and systematic review

Ashraf

Siddique

et al. 2014

WJGE

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Assessment of Cimetropium Bromide Use for the Detection of Gastric Neoplasms During Esophagogastroduodenoscopy

et al. 2022

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Key Points Question Is the use of cimetropium bromide, an antispasmodic agent, associated with higher rates of detection of gastric neoplasms during esophagogastroduodenoscopy (EGD) screening? Findings In this cohort study of 67 683 participants who received EGD screening, the use of cimetropium bromide as premedication was associated with higher gastric neoplasm detection rates during EGD than nonuse. Lesions in the gastric body were detected more frequently in those who received cimetropium bromide compared with those who did not. Meaning This study’s findings suggest that cimetropium bromide may be considered as premedication for the detection of gastric neoplasms during EGD examination among individuals with no contraindications.

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Colonoscopy using back brace support belt: A randomized, prospective trial

et al. 2019

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Background and Aim Looping is a major problem in colonoscopy, and it prolongs procedure time. We evaluated the efficacy and safety of an external abdominal compression device (back brace support belt; Maxbelt) with respect to cecal insertion time and other outcomes. Methods We performed a prospective study on outpatients undergoing elective colonoscopy in Toyoshima Endoscopy Clinic. Subjects were randomly assigned to groups and were subjected to either Maxbelt (n = 39) or no device (control, n = 38) during colonoscopy. The colonoscopist was blinded to the study. The primary outcome that was observed was insertion time. Results The intubation time of the Maxbelt group was shorter than that of the no device group, but the difference was not significant (3.29 vs 4.49 min, P = 0.069). After stratifying by age, the use of Maxbelt significantly decreased cecal intubation time in elderly participants (age ≥ 45) compared to no device group (3.27 vs 5.00 min, P = 0.032). The use of the Maxbelt significantly decreased insertion difficulty encountered by the colonoscopist (P = 0.01). There was no difference in adenoma detection rate, manual pressure, position change, and adverse event. Conclusions The use of a back brace support belt could be a viable approach for colonoscopy in elderly patients. (University Hospital Medical Information Network: UMIN000029361).

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Hyoscine butylbromide administered at the cecum increases polyp detection: a randomized double-blind placebo-controlled trial

Abstract: Hyoscine butylbromide administered at the cecum aids polyp detection. Further studies are required to determine the contribution of colonic spasm to polyp miss rates.

Cited by 49 publications

References 29 publications

Hyoscine for polyp detection during colonoscopy: A meta-analysis and systematic review

Hyoscine for polyp detection during colonoscopy: A meta-analysis and systematic review

Assessment of Cimetropium Bromide Use for the Detection of Gastric Neoplasms During Esophagogastroduodenoscopy

Colonoscopy using back brace support belt: A randomized, prospective trial

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