Hymenoptera Venom Allergy Re-Sting reactions

Mesquita, A M; Carneiro‐Leão, Leonor; Amaral, Luís; Coimbra, Alice

doi:10.23822/eurannaci.1764-1489.156

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Among the patients that were re-stung, there were patients that had an initial reaction of grade 4 and now no reaction to the new sting after a one-year treatment. In some studies, after the first year of treatment they have found an incidence of 80% of local reactions after re-stings [ 37 , 38 ], with about 80% of patients experiencing local reactions during VIT. In this study, only 10% had local reactions after the re-sting and 0% had systemic reactions.…”

Section: Discussionmentioning

confidence: 99%

Real-World Safety and Efficacy Clinical Data of an Improved Allergen-Specific Immunotherapy Product for the Treatment of Bee Venom Allergy

Guzmán

Robaina

et al. 2023

Vaccines

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The aim of this study is to explore the safety and efficacy of bee venom immunotherapy without HSA, in real-life patients. Methods: This is an observational retrospective study developed in seven hospitals in Spain, where patients treated with this immunotherapy were included. They gathered the protocol used to initiate the immunotherapy, adverse reactions, field re-stings, and the patient clinical data (clinical history, biomarkers, and skin prick test). Results: A total of 108 patients were included. In total, 4 protocols were used (5 weeks reaching 200 μg, and 4, 3, and 2 weeks reaching 100 μg). An incidence of systemic adverse reactions for each 100 injections of 1.5, 1.7, 0, and 0.58, respectively, was found. The demographic data showed not to directly affect the appearance of adverse reactions, except for those having a grade 2 systemic reaction with immunotherapy previously had a grade 4 systemic reaction; the IgE to Apis mellifera was 3 times higher in patients with systemic reactions of grade 1 than in the general group, and other specific IgEs were lower in those with systemic reactions. Most of the patients recognized Api m 1 followed by Api m 10. In the sample, 32% experienced spontaneous re-stings, without presenting systemic reactions, after a year of treatment.

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Section: Discussionmentioning

confidence: 99%

Real-World Safety and Efficacy Clinical Data of an Improved Allergen-Specific Immunotherapy Product for the Treatment of Bee Venom Allergy

Guzmán

Robaina

et al. 2023

Vaccines

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“…Although ant venoms are richly diverse in toxins, bioactive compounds, alkaloids, proteins, and peptides [4,[6][7][8], knowledge about the toxinology of these animals remains limited or even largely unknown due extensively to the number of species. The lack of information about the effects derived from crude venom stands out in this scenario, as such understanding is important from a medical point of view in cases of allergies, envenoming, and anaphylaxis, as well as from the perspective of these effects in the process of drug discovery [9][10][11]; this is exemplified by the most famous success of a toxin that bioinspired the design of Captopril, from the observation of the hypotensive effect of the bite by the Brazilian snake Bothrops jararaca [11].…”

Section: Introductionmentioning

confidence: 99%

Shedding Lights on Crude Venom from Solitary Foraging Predatory Ant Ectatomma opaciventre: Initial Toxinological Investigation

Correia

Azevedo

Amorim

et al. 2022

Toxins

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Some species of primitive predatory ants, despite living in a colony, exercise their hunting collection strategy individually; their venom is painful, paralyzing, digestive, and lethal for their prey, yet the toxins responsible for these effects are poorly known. Ectatomma opaciventre is a previously unrecorded solitary hunting ant from the Brazilian Cerrado. To overcome this hindrance, the present study performed the in vitro enzymatic, biochemical, and biological activities of E. opaciventre to better understand the properties of this venom. Its venom showed several proteins with masses ranging from 1–116 kDa, highlighting the complexity of this venom. Compounds with high enzymatic activity were described, elucidating different enzyme classes present in the venom, with the presence of the first L-amino acid oxidase in Hymenoptera venoms being reported. Its crude venom contributes to a state of blood incoagulability, acting on primary hemostasis, inhibiting collagen-induced platelet aggregation, and operating on the fibrinolysis of loose red clots. Furthermore, the E. opaciventre venom preferentially induced cytotoxic effects on lung cancer cell lines and three different species of Leishmania. These data shed a comprehensive portrait of enzymatic components, biochemical and biological effects in vitro, opening perspectives for bio-pharmacological application of E. opaciventre venom molecules.

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“…The prevalence of systemic reactions ranges between 0.3 and 7.5 % in adult population (4). The estimated number of annual mortalities due to insect sting-induced anaphylaxis ranges from 0.03 to 0.45 per one million inhabitants (5) Due to the fear of future reactions, HVA imposes a signifi cant impact in healthrelated Quality of Life (6,7).…”

Section: Introductionmentioning

confidence: 99%

Basophil activation test in the diagnostics of hymenoptera venom allergy

Nemsovska¹,

Waczulı́ková²,

Svecova³

2021

BLL

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OBJECTIVES: The aim of the study was to analyse the diagnostic performance of the basophil activation test (BAT), to compare the diagnostic reliability of BATs performed with different types of allergens, which are available in Slovakia and to verify the correlation between the symptom severity and the sensitivity and specifi city of the BAT in 114 patients with suspected hymenoptera venom allergy (HVA). BACKGROUND: Diagnosis of the HVA and the identifi cation of the appropriate venom for immunotherapy are in Slovakia based on detailed patient'medical history, skin tests and detection of sIgE. In unclear cases, where the clinical decision regarding the relevant insect species for immunotherapy is diffi cult, the cellular tests are recommended in several countries, such as Sweden, Spain, Germany, Denmark and Italy. In Slovakia, BAT is not adapted as s part of routine diagnostic work-up. METHODS: The identifi cation of the culprit hymenoptera species among 114 patients was based on detailed history, skin tests and detection of sIgE. Obtained results were compared with the results acquired by the BAT. RESULTS: The sensitivity of the BAT was 80.8 % and the specifi city was 87.8 %. The sensitivity of the BAT was higher when using Soluprick SQ Allergens, but the specifi city was higher with BŰHLMANN CAST Allergens. In the study no correlation between the symptom severity and the sensitivity and specifi city of the BAT was observed. CONCLUSIONS: The results show that the BAT can be recommended in the identifi cation of the appropriate venom for immunotherapy, the only specifi c treatment that is currently available for patients with HVA. Allergen source is one of critical factors in diagnostic reliability of the BAT (Tab. 4, Ref. 29).

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Hymenoptera Venom Allergy Re-Sting reactions

Cited by 4 publications

References 4 publications

Real-World Safety and Efficacy Clinical Data of an Improved Allergen-Specific Immunotherapy Product for the Treatment of Bee Venom Allergy

Real-World Safety and Efficacy Clinical Data of an Improved Allergen-Specific Immunotherapy Product for the Treatment of Bee Venom Allergy

Shedding Lights on Crude Venom from Solitary Foraging Predatory Ant Ectatomma opaciventre: Initial Toxinological Investigation

Basophil activation test in the diagnostics of hymenoptera venom allergy

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