Hymenolepis nana: Passive transfer of mouse immunity by T-cell subset of phenotype Lyt-1

Asano, Kozo; Shinoda, Masaki; Nakamura, Fuminori; Okamoto, Ken‐ichi

doi:10.1016/0014-4894(86)90193-1

Cited by 18 publications

(11 citation statements)

References 6 publications

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“…Mesenteric lymph node cell (MLNC) suspension was prepared according to our standard methods (Asano et al, 1986(Asano et al, , 1993) and suspended in PBS.…”

Section: Preparation Of Cell Suspensionmentioning

confidence: 99%

“…On day 9, all parasites derived from the primary infection were recovered as lumen-dwelling adult-worms. Immunity was assessed by examining cysticercoids developed in the intestinal villi on day 9, 4 days after the challenge (Asano et al, 1986).…”

Section: H Nana Infection and Assay For Protective Immunitymentioning

confidence: 99%

“…The free oncospheres penetrate the intestinal villi, where they grow into cysticercoids within 5 days. When fully grown, the larvae migrate to the lumen of the small intestine, and develop into mature worms (Reed et al, 1977;Asano et al, 1986). Experimental evidence from studies of mice clearly show that strong immunity to reinfection develops during the tissue phase (larval growing in the intestinal villi), and that a second infection with eggs will be completely rejected.…”

mentioning

confidence: 99%

“…Experimental evidence from studies of mice clearly show that strong immunity to reinfection develops during the tissue phase (larval growing in the intestinal villi), and that a second infection with eggs will be completely rejected. The lumen dwelling-adult worms are not immunogenic to egg challenge (Reed et al, 1977;Asano et al, 1986). It has been shown that the immune responses responsible for protection to egg challenge are mediated by T cells (Reed et al, 1977;Asano et al, 1986).…”

mentioning

confidence: 99%

“…The lumen dwelling-adult worms are not immunogenic to egg challenge (Reed et al, 1977;Asano et al, 1986). It has been shown that the immune responses responsible for protection to egg challenge are mediated by T cells (Reed et al, 1977;Asano et al, 1986). Furthermore, in our previous work, we used various physical and biological methods to isolate protective lymphocytes from mesenteric lymph node cell populations found in H. nana-infected mice, and reported that the cells responsible for protective immunity are helper T cells, especially Thl subtype Asano etal, 1993).…”

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confidence: 99%

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Suppressive Activity of the Chloroform Extract of Tripterygium wilfordii Hook f on Effector T Cell Activation during Hymenolepis nana Infection in Mice

Asano

Matsuishi

et al. 1998

Am. J. Chin. Med.

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The chloroform extract of Tripterygium wilfordii Hook f (TWH extract) administered into mice daily at doses of 80.0 to 200.0 micrograms/kg (but not 40.0 micrograms/kg) caused suppression of protective immunity to Hymenolepis nana when the extract was injected subcutaneously during the induction phase of protective immunity. Daily administration of 200.0 micrograms/kg TWH extract, during the course of larval development from challenge, also suppressed protective immunity. Inhibition of protective immunity was only observed in mice that received TWH extract for 6 days at a daily dose of 200.0 micrograms/kg and were challenged 24 h after the final injection. TWH extract did not inhibit formation of effector cells that mediate delayed type hypersensitivity (DTH) to H. nana egg antigen when the extract was administered subcutaneously at a dose of 200.0 micrograms/kg/day for 5 days before cell preparation. However, TWH extract did inhibit DTH effector cell activation when cells prepared from infected, PBS-injected mice were transferred into 200.0 micrograms/kg TWH extract-treated recipient mice. These results strongly indicate that TWH extract cannot inhibit the generation of effector cells but will suppress their function in vivo.

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“…Mesenteric lymph node cell (MLNC) suspension was prepared according to our standard methods (Asano et al, 1986(Asano et al, , 1993) and suspended in PBS.…”

Section: Preparation Of Cell Suspensionmentioning

confidence: 99%

Section: H Nana Infection and Assay For Protective Immunitymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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