Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1

Zheng, Li; Yan, Xiaojun; Xu, Jilin; Chen, Haimin; Lin, Wei

doi:10.1007/s10438-005-0006-8

Cited by 31 publications

(20 citation statements)

References 24 publications

(20 reference statements)

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“…According to the MS and NMR data of 7, the main difference from 6 was lack of a hydroxyl group in the indole moiety. The MS and NMR data of 7 matched well with reported data [8], and was identified as (1H-indol-3-yl) carboxylic acid methyl ester which was previously reported from marine-derived bacteria [8] and fungi [21], and red alga [22], with cytotoxicity against K562 human chronic leukemia (MIC s 14.0 μg/mL) [21]. It is expected that (1H-indol-3-yl) oxoacetamide derivatives serve as intermediate for the biogenesis of co-occurring bisindole alkaloids, topsentins and hamacanthins [11,12] (Scheme 1).…”

Section: (100) /224(100)supporting

confidence: 74%

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Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

Bao

2007

Mar. Drugs

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Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.

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Section: (100) /224(100)supporting

confidence: 74%

“…To date, dozens of simple monoindole derivatives were reported from marine sources, such as sponges [1−5], ascidians [6], bryozoans [7], bacteria [8], and fungi [9]. Some of these metabolites were reported to exhibit antibacterial [2,10], antifungal [3], and auxin [4] activities.…”

Section: Introductionmentioning

confidence: 99%

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

Bao

2007

Mar. Drugs

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“…The activity in ethyl acetate extracts were, in general, higher than Zheng et al (2005) who have reported moderate activity (1-5 mm) in the ethyl acetate extract of two sponge associated bacteria against pathogenic bacteria. The activity in culture supernatants of the associated colonies indicated the production of exocellular metabolites.…”

Section: Resultsmentioning

confidence: 71%

Isolation and screening of marine associated bacteria from Tamil Nadu, Southeast coast of India for potential antibacterial activity

et al. 2008

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The bacteria associated with living surfaces are rich sources of bioactive metabolites. In the present study, 182 heterotrophic epibacterial colonies, isolated from seaweeds (44%), ascidians (30.2%), barnacles (10.4%) and molluscan egg mass (15.4%), were subjected to high throughput screening by cross streaking method against six human pathogenic bacteria, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio cholerae, Proteus mirabilis and Klebsiella pneumoniae. The 137 epibacterial isolates, which showed activity against at least one human bacterial pathogen in cross streaking method, were further cultured and the ethyl acetate extract of the culture broth (100 μg/disc) was assayed for antibacterial activity through disc diffusion method. The four epibacterial colonies, BR1, EM13, EM14 and PC4, isolated from the barnacle Balanus amphitrite, seaweed Enteromorpha compressa, and ascidian Polyclinum constellatum showed broad spectral antibacterial activity.

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“…Based on earlier reports, high microbial diversity, especially of Actinobacteria, was found within this sponge (Dharmaraj 2010;Sun et al 2010;Xin et al 2008;Xin et al 2009;Zhang et al 2006;Zhang et al 2008;Zheng et al 2005). Our preliminary work showed that the sponge was a good source for the dehalogenase producing bacteria isolation (Huang et al 2010).…”

Section: Introductionmentioning

confidence: 76%

Phylogenetic diversity and characterization of 2-haloacid degrading bacteria from the marine sponge Hymeniacidon perlevis

Huang

Xin

Cao

et al. 2011

World J Microbiol Biotechnol

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A total of 139 2-haloacid degrading bacteria strains were isolated from the marine sponge Hymeniacidon perlevis using a modified enrichment medium and a pH indicator method. After screening on indicator agar and 2-chloropropionic acid (2-CPA) liquid medium, 11 isolates with high degrading activities were characterized and initially identified. Seven of the 11 isolates were able to degrade 2-CPA at 8% salt, and four isolates (DEH 66, DEH 99, DEH125 and DEH138) degraded 2-CPA at 15% salt. Eight of the 11 isolates utilized all four types of organohalogen compounds used in this study. The DEH99 and DEH138 isolates exhibited the best enantioselectivity towards (S)-2-chloropropionic acid (S-CPA) and (R)-2-chloropropionic acid (R-CPA), respectively. The dehalogenase activities of DEH84 against racemic CPA, DEH99 against S-CPA, DEH138 against R-CPA and DEH130 against racemic CPA were 0.16U/mg, 0.06U/mg, 0.12U/ mg and 0.19U/mg, respectively. Based on 16S rRNA sequence analysis, the 11 isolates were clustered into the Rhodobacteraceae family of a-proteobacteria and the Pseudomonadaceae family of c-proteobacteria. To our knowledge, this is the first report detailing the isolation of organisms of Pseudomonas stuzeri sp. and the Rhodobacteraceae family with 2-haloacid dehalogenase activity from marine sponges.

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Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1

Cited by 31 publications

References 24 publications

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

Isolation and screening of marine associated bacteria from Tamil Nadu, Southeast coast of India for potential antibacterial activity

Phylogenetic diversity and characterization of 2-haloacid degrading bacteria from the marine sponge Hymeniacidon perlevis

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