Hylocereus undatus flower extract suppresses OVA-induced allergic asthma in BALb/c mice by reducing airway inflammation and modulating gut microbiota

Liao, Wanzhong; Liu, Wei; Yan, Yu; Li, Liang; Tong, Jianjun; Huang, Y.; Guo, Shuhai; Jiang, Weizhe; Fu, Shujie

doi:10.1016/j.biopha.2022.113476

Cited by 9 publications

(4 citation statements)

References 81 publications

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“…Intestinal SCFAs migrate into pulmonary circulation and affect AA-related immune functions ( Verstegen et al, 2021 ). Notably, the relative abundance of the Lachnospiraceae_NK4A136_group is negatively correlated with inflammatory serum markers in ovalbumin-induced AA mice ( Liao et al, 2022 ). We also observed significantly decreased Lachnoclostridium numbers in this study.…”

Section: Discussionmentioning

confidence: 99%

Heat-killed Akkermansia muciniphila ameliorates allergic airway inflammation in mice

Yoon,

Lim,

Byeon

et al. 2024

Front. Microbiol.

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Allergic asthma (AA) is a common inflammatory airway disease characterized by increased airway hyper-responsiveness (AHR), inflammation, and remodeling. Akkermansia muciniphila is a strictly anaerobic bacterium residing in the gut and is a promising next-generation probiotic to improve metabolic inflammatory syndrome. A recent study suggested the beneficial effect of live A. muciniphila on allergic airway inflammation (AAI) in mice. However, whether the heat-killed form can improve AAI requires further investigation. Mice sensitized and challenged with house dust mites (HDM) develop AA hallmarks including inflammatory cell infiltration, goblet cell hyperplasia, and subepithelial collagen deposition in the lungs. These phenomena were reversed by oral administration of the heat-killed A. muciniphila strain EB-AMDK19 (AMDK19-HK) isolated from the feces of healthy Koreans. Furthermore, AMDK19-HK diminished the HDM-induced AHR to inhaled methacholine, lung mast cell accumulation, and serum HDM-specific IgE levels. It also led to the overall suppression of IL-4, IL-13, and eotaxin production in bronchoalveolar lavage fluids, and Il4, Il5, Il13, and Ccl17 gene expression in lung tissues. Moreover, AMDK19-HK suppressed Th2-associated cytokine production in the splenocytes of HDM-sensitized mice in vitro. Additionally, a combination of 16S rRNA gene sequencing and short-chain fatty acid (SCFA) analysis in cecal samples revealed that AMDK19-HK modulated the relative abundance of circulating SCFA-associated gut genera, including a positive correlation with Lachnospiraceae_ NK4A136_group and a negative correlation with Lachnoclostridium and significantly increased cecal SCFA concentrations. Finally, AMDK19-HK improved intestinal mucosal barrier function. These results suggest that the oral administration of AMDK19-HK ameliorates HDM-induced AAI in mice by suppressing Th2-mediated immune responses and could have a protective effect against AA development.

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Section: Discussionmentioning

confidence: 99%

Heat-killed Akkermansia muciniphila ameliorates allergic airway inflammation in mice

Yoon,

Lim,

Byeon

et al. 2024

Front. Microbiol.

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“…Recent reports have explored treatment options for allergic inflammation, including drugs that target SIRT1 to provide relief for allergic diseases ( Table 1 ). Among the drugs that have demonstrated effectiveness in alleviating AAI are Allopurinol, GW9962, Hylocereus undatus flower (HUF), Pterostilbene (Pts), Gentiopicroside (GPS), and EX-527 ( 26 , 33 , 43 , 51 , 112 , 113 ). Studies have found that SIRT1 expression in immune cells can help relieve allergic rhinitis, and the use of SIRT1 agonist resveratrol has shown promise in treating AR ( 64 , 71 ).…”

Section: Treatmentmentioning

confidence: 99%

The role of deacetylase SIRT1 in allergic diseases

Lu,

Tang,

Wang

et al. 2024

Front. Immunol.

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The silent information regulator sirtuin 1 (SIRT1) protein is an NAD+-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and non-histone proteins. SIRT1 has been reported to be involved in several physiological or pathological processes such as aging, inflammation, immune responses, oxidative stress and allergic diseases. In this review, we summarized the regulatory roles of SIRT1 during allergic disorder progression. Furthermore, we highlight the therapeutic effects of targeting SIRT1 in allergic diseases.

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“…7 Numerous studies state that gut microbiota is associated with asthma pathogenesis. 8,9 Liao et al 10 analyzed the treatment effects of Hylocereus undatus flower (HUF) extract on allergic asthma; they demonstrated that HUF attenuated pulmonary lesions and modulated the intestinal flora associated with asthma. Furthermore, investigation of fecal samples from patients with asthma suggested that asthma altered the gut microbiome, among which specific bacteria were found to be related to increased serum IgE level.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, there has been growing interest in natural plants with strong anti-inflammatory properties that positively modulate the gut microbiota. 10,15 LBT is a type of postfermented dark tea made from fresh tea (Camellia sinensis) leaves in Cangwu, Guangxi province, China. It is renowned for its distinctive betel flavor and is rich in polyphenols, flavonoids, alkaloids, polysaccharides, and other activated bioactive metabolites.…”

Section: Introductionmentioning

confidence: 99%

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

Guo,

Shi,

et al. 2023

Food Funct.

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Hylocereus undatus flower extract suppresses OVA-induced allergic asthma in BALb/c mice by reducing airway inflammation and modulating gut microbiota

Cited by 9 publications

References 81 publications

Heat-killed Akkermansia muciniphila ameliorates allergic airway inflammation in mice

Heat-killed Akkermansia muciniphila ameliorates allergic airway inflammation in mice

The role of deacetylase SIRT1 in allergic diseases

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

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