Hyena disease in cattle: a review

Espinasse, J.; Parodi, André-Laurent; Constantin, Angela Petruta; Viso, Michel; Laval, Alexandra Helene Denise Yvonne

doi:10.1136/vr.118.12.328

Cited by 14 publications

(5 citation statements)

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“…One calf had bilateral hyperextension of all hindlimb joints due to spastic contraction of limb muscles. Another calf had a caudally declining dorsal profile resembling hyena disease [17] . The splanchnocranium, mandible and palate were normal, as was the heart, and there was no polydactyly.…”

Section: Resultsmentioning

confidence: 99%

Deletion in the EVC2 Gene Causes Chondrodysplastic Dwarfism in Tyrolean Grey Cattle

et al. 2014

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During the summer of 2013 seven Italian Tyrolean Grey calves were born with abnormally short limbs. Detailed clinical and pathological examination revealed similarities to chondrodysplastic dwarfism. Pedigree analysis showed a common founder, assuming autosomal monogenic recessive transmission of the defective allele. A positional cloning approach combining genome wide association and homozygosity mapping identified a single 1.6 Mb genomic region on BTA 6 that was associated with the disease. Whole genome re-sequencing of an affected calf revealed a single candidate causal mutation in the Ellis van Creveld syndrome 2 (EVC2) gene. This gene is known to be associated with chondrodysplastic dwarfism in Japanese Brown cattle, and dwarfism, abnormal nails and teeth, and dysostosis in humans with Ellis-van Creveld syndrome. Sanger sequencing confirmed the presence of a 2 bp deletion in exon 19 (c.2993_2994ACdel) that led to a premature stop codon in the coding sequence of bovine EVC2, and was concordant with the recessive pattern of inheritance in affected and carrier animals. This loss of function mutation confirms the important role of EVC2 in bone development. Genetic testing can now be used to eliminate this form of chondrodysplastic dwarfism from Tyrolean Grey cattle.

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Section: Resultsmentioning

confidence: 99%

Deletion in the EVC2 Gene Causes Chondrodysplastic Dwarfism in Tyrolean Grey Cattle

et al. 2014

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“…Some ground slices were polished with 5-and 0.3-µm alumina on Bovine hyena disease is regarded as a disorder of skeltal development, localized mainly in the pelvic limbs of young calves. A virus may cause it [7], and high doses of vitamin AD 3 E premix may be related to it [10,21]. Some investigators [7,10,21] reported that the pelvic limbs of calves with hyena disease showed a deformation and a local disappearance of epiphyseal growth plates.…”

Section: Animalsmentioning

confidence: 99%

“…A virus may cause it [7], and high doses of vitamin AD 3 E premix may be related to it [10,21]. Some investigators [7,10,21] reported that the pelvic limbs of calves with hyena disease showed a deformation and a local disappearance of epiphyseal growth plates. Recently, high doses of vitamin A as well as vitamin AD 3 E premix have caused hyena disease in young calves [15][16][17].…”

Section: Animalsmentioning

confidence: 99%

Local Disappearance of Epiphyseal Growth Plates in Rats with Hypervitaminosis A.

Kodaka

Takaki

Soeta

et al. 1998

The Journal of Veterinary Medical Science

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ABSTRACT. Epiphyseal growth plates of proximal tibiae in rats with high doses of vitamin A (V-A) were observed. Of 4 groups, each consisting of 5 rats, three groups were given V-A at doses, IU/100 g by body weight/day, of 50,000, 100,000, and 150,000, respectively. The other group rats were given no V-A (control). Rats were administered V-A for the 5 days from 4 weeks after birth and sacrificed at 12 weeks after birth. Three rats of the 150,000 IU group died during the period of observation. The decalcified sections were stained with hematoxylin-eosin or toluidine blue. In the ground sections, microradiography, backscattered electron imaging, and energy-dispersive Xray microanalysis were performed. These observations suggest that the local disappearance of epiphyseal growth plates under high doses of V-A goes in the order of the increased doses through the process of (1) calcified cartilage areae appearing in the resting cell zone, (2) some of the calcified areae extending in the growth plate towards the diaphysial side, (3) bone tissue replacing the calcified areae, and (4) the local disappearing of the growth plate. Such a local disappearance may be formed in the stressed proximal regions of tibiae. -KEY WORDS: calcified cartilage, epiphyseal growth plate, hypervitaminosis A, local disappearance, sulfur content.

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“…Hyena disease of cattle was first reported in France and since then has been recognised in many other countries and described as a skeletal disorder. BVDV has been identified as the causative agent of this disease (Russo, et al, 1985;Espinasse, et al, 1986;Nettleton, 1990).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of BVD infection in ruminants in Serbia

Kurčubić¹,

Đoković²,

Ilić³

et al. 2015

JCEA

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The aim of this article is to provide a historical summary of worldwide Bovine Viral Diarrhoea Virus (BVDV) prevalence data through a number of studies, review the current knowledge and published data on the presence and prevalence of BVDV infection among ruminants in Serbia, and consequently open questions as to the possibilities for the implementation of the control programme in Serbia. Rezime Cilj ovog rada je da obezbedi podatke za istorijski rezime o rasprostranjenosti virusa goveĊe dijareje (BVDV) širom sveta kroz brojna ispitivanja, razmatra trenutna znanja i objavi podatake o prisustvu i rasprostranjenosti infekcije BVDV meĊu preţivarima u Srbiji, a samim tim i postavi pitanja u pogledu mogućnosti za primenu programa kontrole u Srbiji.Ključne reči: virus goveĊe dijareje (BVDV), rasprostranjenost (prevalenca), ELISA, reverzna transkipcija -lanĉana reakcija polimeraze (RT-PCR), virus neutralizacioni test (VNT)

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Hyena disease in cattle: a review

Cited by 14 publications

References 0 publications

Deletion in the EVC2 Gene Causes Chondrodysplastic Dwarfism in Tyrolean Grey Cattle

Deletion in the EVC2 Gene Causes Chondrodysplastic Dwarfism in Tyrolean Grey Cattle

Local Disappearance of Epiphyseal Growth Plates in Rats with Hypervitaminosis A.

Prevalence of BVD infection in ruminants in Serbia

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