Hydroxytyrosol Alleviates Obesity-Induced Cognitive Decline by Modulating the Expression Levels of Brain-Derived Neurotrophic Factors and Inflammatory Factors in Mice
Shenlin Liu,
Yalong Lu,
Dan Tian
et al.
Abstract:Hydroxytyrosol (HT; 3,4-dihydroxyphenyl ethanol) is an
important
functional polyphenol in olive oil. Our study sought to evaluate the
protective effects and underlying mechanisms of HT on obesity-induced
cognitive impairment. A high-fat and high-fructose-diet-induced obese
mice model was treated with HT for 14 weeks. The results show that
HT improved the learning and memory abilities and enhanced the expressions
of brain-derived neurotrophic factors (BDNFs) and postsynaptic density
proteins, protecting neurona… Show more
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