Hydroxysafflor yellow A from safflower (Carthamus tinctorius L.) prevents cerebral ischemia-reperfusion injury in rats

Abstract

In this study we extracted hydroxysafflor yellow A (HSYA) from safflower and investigate its preventive effect on cerebral ischemia-reperfusion injury (CIRI) in rats. HSYA with 89.78% purity was extracted from safflower. Ninety rats were divided into sham-operated, model, low-dose HSYA, high-dose HSYA and nimodipine groups. The CIRI model was established in latter three groups. After 30 min from ischemia beginning, the low-dose and high-dose HSYA groups were treated with 2 and 4 mg/kg HSYA via tail-vein injection, respectively. The nimodipine group was treated with 2 mg/kg nimodipine. Results showed that, at 24 h after ischemia, compared with model group, in high-dose HSYA and nimodipine groups the neurological symptom score was significantly decreased (P < 0.05), the brain water content was significantly decreased (P < 0.05), the brain infarction area percentage was significantly decreased (P < 0.05), the serum IL-6 and IL-1β levels were significantly decreased (P < 0.05), and the brain tissue phosphorylated p38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated nuclear factor kappa B (p-NF-κB) p65 protein expression levels were significantly decreased (P < 0.05). In conclusion, HSYA can inhibit the p38 MAPK/NF-κB pathway and reduce the inflammatory response, thus exerting the preventive effect on CIRI in rats.

Effect of lipoxin A4 methyl ester from arachidonic acid on JAK2/STAT3 pathway after cerebral ischemia-reperfusion injury

“…Presenting in neuronal cytoplasm and a small number of glial cells, JAK-STAT signalling proteins are mainly distributed in the cortex and hippocampus (Wu et al, 2018). Cerebral ischemia injury models proved that STAT3 phosphorylation mainly occurs in the neurons in layers IV-V of the cortex, corpora striata, and hippocampal tissues (Sharma et al, 2011;Wang et al, 2022), along with astrocytes, microglial cells, oligodendrocytes, and vascular endothelial cells (Liang et al, 2016). These data (Wu et al, 2018;Sharma et al, 2011;Liang et al, 2016) revealed the effect of JAK2/ STAT3 activation on regulating the physiologic status in cerebral injuries.…”

Copper phosphide–phosphorus (Cu3P/P) hybrid nanomaterials: an in situ dioxygen activator in ambient aqueous conditions for advanced oxidation process

“…Recently, advanced oxidation processes (AOPs) have been considered as a promising choice to generate reactive oxygen species (ROS) that can degrade persistent and recalcitrant antibiotic contaminants into harmless small molecules. [1][2][3][4][5][6][7] To efficiently generate ROS, AOPs generally consist of energy systems (thermal, photochemical, electrochemical or sonochemical), homogeneous or heterogeneous catalysis systems and chemical oxidants. [8][9][10][11][12] The external addition of chemical oxidants (e.g., H 2 O 2 , peroxymonosulfate (PMS) and persulfate (PS)), which is still quite costly, is applied in most AOPs.…”

“…[1][2][3][4][5][6][7] To efficiently generate ROS, AOPs generally consist of energy systems (thermal, photochemical, electrochemical or sonochemical), homogeneous or heterogeneous catalysis systems and chemical oxidants. [8][9][10][11][12] The external addition of chemical oxidants (e.g., H 2 O 2 , peroxymonosulfate (PMS) and persulfate (PS)), which is still quite costly, is applied in most AOPs. [13][14][15][16] Therefore, the in situ activation of dioxygen to yield ROS has been considered as an economical and environmentally friendly route for AOPs, as dioxygen is inexhaustible and readily available in the atmosphere.…”

Catalytic Ozonation in Pulp and Paper Industry Wastewater Treatment: A Bibliometric Analysis

“…These methods mainly rely on the generation of hydroxyl free radicals, which have a high electrochemical oxidant power and oxidizing potential. Due to their high oxidizing potential, these methods are helpful for treating organic and inorganic contaminants in wastewater to ensure a safe environment 28, 31, 32. There are various methods of AOPs, whose performance is summarized in Tab.…”