Hydroxypropyl Methylcellulose Based Cephalexin Extended Release Tablets: Influence of Tablet Formulation, Hardness and Storage on in Vitro Release Kinetics

Dissolution Behavior, Stability and Anti-Inflammatory Activity of Ketoprofen Coated Tripolyphosphate Modified Chitosan Nanoparticle

“…Mechanism of Korsmeyer-Peppas kinetic models indicate that the drug regard less of the matrix is dominated by the diffusion process. The study is in line with research conducted by Sugita et al [6][7], Shoaib et al [11], Kim et al [24], and Sarvanan et al [12], but different from chitosan-alginate crosslinked with glutaraldehyde a mechanism in acid medium is dominated by the first order, whereas in alkaline medium it follow order-0 and Hixson-Crowell. Release mechanism shown by the first and zero order equation support through the mechanism of drug release process of erosion, while the Hixson-Crowell equation signifies apart by drug diffusion mechanism accompanied by erosion events [6].…”

“…Conversely, if a hydrated matrix can not survive long in a certain time, then the rate of drug release is controlled by erosion events and patterns of linear release with time. Sugita et al [12] reported that the test results of the membrane diffusion of ketoprofen coated by chitosan-guar crosslinked with glutaraldehyde through a mechanism that begins with the swelling of the membrane when the membrane in contact with the fluid, then the formation and opening of the pore membrane so that the drugs can pass through the matrix .The thicker the layer of gel that must be passed by ketoprofen, the greater the barrier that must be ketoprofen overcome for migration [23]. Chitosanalginate membrane with a thickness of 10-34 μm successfully passed ketoprofen dose of 50 and 75 mg/L both at 37 and 42 °C.…”

“…The parameters include the order of the Determination of the reaction order is done using graphical methods, namely by looking at the value of the coefficient of determination, R 2 curves derived from the relationship between the concentration of ketoprofen and time [12][13]. The three formulas show the release kinetics of ketoprofen in both acidic and alkaline medium, all formulas followed Korsmeyer-Peppas kinetics model.…”

Ispaghula Husk-Based Extended Release Tablets of Diclofenac Sodium: Formulation, Evaluation and <i>In vitro</i> Release Studies

“…The formulated tablets were tested [12] for weight variation, thickness, friability, hardness and disintegration. The weight of 20 tablets from each batch was taken using an electronic balance (Mettler Toledo, PL 303) and the mean weight calculated.…”

Roller Compaction of Hydrophilic Extended Release Tablets—Combined Effects of Processing Variables and Drug/Matrix Former Particle Size

“…A limited number of studies have been published evaluating the suitability of dry granulation as the granulation method in the manufacture of HPMC-based hydrophilic matrix tablets (10)(11)(12). Hariharan et al studied the effects of formulation variables of diclofenac and HPMC-based matrix tablets prepared by roller compaction (12).…”