Hydroxypropyl methacrylamide-based copolymeric nanoparticles loaded with moxifloxacin as a mucoadhesive, cornea-penetrating nanomedicine eye drop with enhanced therapeutic benefits in bacterial keratitis

Ch, Sanjay; Mishra, Priyasha; Bhatt, Himanshu; Ghosh, Balaram; Roy, Sanhita; Biswas, Swati

doi:10.1016/j.colsurfb.2021.112113

Cited by 18 publications

(18 citation statements)

References 41 publications

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“…The ionic character of bond between boron and nitrogen atoms are responsible for chemical stability and its resistance to oxidation . BNNT are biocompatible in living cells which make them potential candidates for use in nanomedicine applications. ,− The dispersion and aqueous solubility of boron nitride can be improved after functionalization with molecules due to the ionic nature of B–N bonds and weak interactions such as π–π interaction, hydrogen bond interaction, and the cation−π interaction. ,,,, BNNT are semiconductors with wide band gap and independent of tube diameter and chirality . The wetting properties of BN play a crucial role to characterize and identify appropriate coating materials that increase the therapeutic effect.…”

Section: Boron-based Materials For Pttmentioning

confidence: 99%

“…69,146−150 The dispersion and aqueous solubility of boron nitride can be improved after functionalization with molecules due to the ionic nature of B−N bonds and weak interactions such as π−π interaction, hydrogen bond interaction, and the cation−π interaction. 26,124,124,151,152 BNNT are semiconductors with wide band gap and independent of tube diameter and chirality. 153 The wetting properties of BN play a crucial role to characterize and identify appropriate coating materials that increase the therapeutic effect.…”

Section: Properties and Biophysical Response Of Livingmentioning

confidence: 99%

“…The recent use of graphene and graphene oxide nanomaterials has increased in the fields of electronics and pharmaceuticals mostly due to its advantageous polymeric barrier properties. , However, research has found that graphene shows good amount of adsorption in many organic contaminants as well, including dyes, antibiotics, pesticides, etc. − Thus, it is necessary for us to ascertain the molecular adsorption properties to control the possible risks graphene may have on the various therapies its being researched on.…”

Section: Graphene and Its Derivatives For Pttmentioning

confidence: 99%

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Potential and Progress of 2D Materials in Photomedicine for Cancer Treatment

Bhatt

Pena-Zacarias

Beaven

et al. 2023

ACS Appl. Bio Mater.

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Over the last decades, photomedicine has made a significant impact and progress in treating superficial cancer. With tremendous efforts many of the technologies have entered clinical trials. Photothermal agents (PTAs) have been considered as emerging candidates for accelerating the outcome from photomedicine based cancer treatment. Besides various inorganic and organic candidates, 2D materials such as graphene, boron nitride, and molybdenum disulfide have shown significant potential for photothermal therapy (PTT). The properties such as high surface area to volume, biocompatibility, stability in physiological media, ease of synthesis and functionalization, and high photothermal conversion efficiency have made 2D nanomaterials wonderful candidates for PTT to treat cancer. The targeting or localized activation could be achieved when PTT is combined with chemotherapies, immunotherapies, or photodynamic therapy (PDT) to provide better outcomes with fewer side effects. Though significant development has been made in the field of phototherapeutic drugs, several challenges have restricted the use of PTT in clinical use and hence they have not yet been tested in large clinical trials. In this review, we attempted to discuss the progress, properties, applications, and challenges of 2D materials in the field of PTT and their application in photomedicine.

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Section: Boron-based Materials For Pttmentioning

confidence: 99%

Section: Properties and Biophysical Response Of Livingmentioning

confidence: 99%

Section: Graphene and Its Derivatives For Pttmentioning

confidence: 99%

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Potential and Progress of 2D Materials in Photomedicine for Cancer Treatment

Bhatt

Pena-Zacarias

Beaven

et al. 2023

ACS Appl. Bio Mater.

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“…In ophthalmology, corneal spheroids were primarily used for extracting highly proliferative cells through sphere formation experiments and have only recently been applied to permeability and cellular uptake studies. The focus of these studies was on the potential of mucoadhesive voriconazole-loaded nanomicelles for the treatment of fungal keratitis and the time-dependent penetration efficiency of moxifloxacin-loaded polymeric nanoparticles for the treatment of bacterial keratitis. , Weng et al evaluated the efficacy of cRGD-functionalized nanomicelles encapsulating flurbiprofen for the treatment of ocular inflammation. Due to their mucoadhesive properties and superior ocular surface retention, nanomicelles displayed enhanced corneal penetration in corneal spheroids.…”

Section: In Vitro Reconstructed Corneal Tissue Models To Study Drug P...mentioning

confidence: 99%

In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea

et al. 2023

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Drug permeation across the cornea remains a major challenge due to its unique and complex anatomy and physiology. Static barriers such as the different layers of the cornea, as well as dynamic aspects such as the constant renewal of the tear film and the presence of the mucin layer together with efflux pumps, all present unique challenges for effective ophthalmic drug delivery. To overcome some of the current ophthalmic drug limitations, the identification and testing of novel drug formulations such as liposomes, nanoemulsions, and nanoparticles began to be considered and widely explored. In the early stages of corneal drug development reliable in vitro and ex vivo alternatives, are required, to be in line with the principles of the 3Rs (Replacement, Reduction, and Refinement), with such methods being in addition faster and more ethical alternatives to in vivo studies. The ocular field remains limited to a handful of predictive models for ophthalmic drug permeation. In vitro cell culture models are increasingly used when it comes to transcorneal permeation studies. Ex vivo models using excised animal tissue such as porcine eyes are the model of choice to study corneal permeation and promising advancements have been reported over the years. Interspecies characteristics must be considered in detail when using such models. This review updates the current knowledge about in vitro and ex vivo corneal permeability models and evaluates their advantages and limitations.

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“…The NP drug carrier increases the bioavailability of the drug and reduces the side effects. It was reported that hydroxypropyl methacrylamide-loaded moxifloxacin copolymer NPs were effective in penetrating the cornea in the treatment of bacterial keratitis (Ch, Mishra et al, 2021). Moreover, they allowed for the sustained release of moxifloxacin and increased the retention time in the eye.…”

Section: Polymer Nanoparticlesmentioning

confidence: 99%

Nanoparticles in ocular applications and their potential toxicity

Cao

Yang

et al. 2022

Front. Mol. Biosci.

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Nanotechnology has been developed rapidly in recent decades and widely applied in ocular disease therapy. Nano-drug delivery systems overcome the bottlenecks of current ophthalmic drug delivery and are characterized with strong biocompatibility, stability, efficiency, sustainability, controllability, and few side effects. Nanoparticles have been identified as a promising and generally safe ophthalmic drug-delivery system based on the toxicity assessment in animals. Previous studies have found that common nanoparticles can be toxic to the cornea, conjunctiva, and retina under certain conditions. Because of the species differences between humans and animals, advanced in vitro cell culture techniques, such as human organoids, can mimic the human organism to a certain extent, bringing nanoparticle toxicity assessment to a new stage. This review summarizes the advanced application of nanoparticles in ocular drug delivery and the potential toxicity, as well as some of the current challenges and future opportunities in nanotoxicological evaluation.

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Hydroxypropyl methacrylamide-based copolymeric nanoparticles loaded with moxifloxacin as a mucoadhesive, cornea-penetrating nanomedicine eye drop with enhanced therapeutic benefits in bacterial keratitis

Cited by 18 publications

References 41 publications

Potential and Progress of 2D Materials in Photomedicine for Cancer Treatment

Potential and Progress of 2D Materials in Photomedicine for Cancer Treatment

In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea

Nanoparticles in ocular applications and their potential toxicity

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