Hydroxyproline Excretion and Height Velocity in Adolescent Boys

Zorab, P.A.; Clark, Stephanie; Harrison, Ailie; Seel, J. R.

doi:10.1136/adc.45.244.763

Cited by 19 publications

(12 citation statements)

References 10 publications

(16 reference statements)

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“…All except 2 of the 12 children considered to be classifiable as 'primordial dwarfs' (Table II) (with growth hormone deficency) 4 6/12 3 5/12 4 10/12 2 6/12 8 1/12 5 2/12 9 2/12 8 8/12 9 6/12 6 10 3/12 7 6/12 12 9/12 and Ziff, 1964;Whitehead, 1965;Zorab et al, 1970). Our present studies show that during childhood hydroxyproline excretion, when expressed per 24 hours per m2 body surface, can discriminate between stunted growth of endocrine origin and primordial dwarfism without endocrine disturbances, provided a hydroxyproline-free diet is ensured.…”

Section: Resultsmentioning

confidence: 99%

Hydroxyproline excretion in various forms of growth failure.

Teller¹,

Genscher²,

Burkhardt³

et al. 1973

Archives of Disease in Childhood

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. Hydroxyproline excretion in various forms of growth failure. The hydroxyproline excretion in 24-hour urines was determined in 26 children and adolescents whose heights were below the 3rd centile. In 14 growth failure was related to endocrine defects, and in 12 growth failure was unrelated to endocrine defect. The normal range of urinary hydroxyproline excretion at different ages was determined in 40 normal children aged between 3 and 14 years. All subjects were placed on a hydroxyproline-free diet before and during urine collections. Hydroxyproline excretion was expressed as mg/m2 body surface per 24 hr.Children with pituitary and hypothyroid dwarfism had decreased excretion of hydroxyproline. Giving growth hormone and/or thyroid hormone raised the hydroxyproline excretion to normal. Children with growth failure unrelated to endocrine defect had normal hydroxyproline excretion.During childhood, urinary hydroxyproline excretion provides a useful means for distinguishing between endocrine dwarfism (low excretion) and non-endocrine dwarfism (normal excretion). In older adolescents and adults it is less reliable.The amino acid hydroxyproline is formed by hydroxylation of proline within the collagen (for review see Adams, 1970), and 95% of urinary hydroxyproline is derived from collagen in bones. Under conditions of a hydroxyproline-free diet the urinary excretion of hydroxyproline can be considered a parameter of bone metabolism and bone growth (for reviews see Kivirikko, 1970;Sjoerdsma et al., 1965).Varying levels of hydroxyproline in 24-hour urines have been described in connexion with several skeletal disorders (Burkhardt, Dietrich, and Rommel, 1970;Filliat et al., 1965;Haddad, Couranz, and Avioli, 1970;Laitinen, Nikkila, and Kivirikko, 1966;Nakagawa et al., 1967; RuizTorres, 1969;Smiley and Ziff, 1964). Decreased hydroxyproline excretion has been described in hypopituitary and hypothyroid dwarfs (Chiumello and Del

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Section: Resultsmentioning

confidence: 99%

Hydroxyproline excretion in various forms of growth failure.

Teller¹,

Genscher²,

Burkhardt³

et al. 1973

Archives of Disease in Childhood

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“…Bone-specific alkaline phosphatase secretion reflects bone formation, closely follows height velocity, 31-37 and has been proposed as a useful marker for scoliosis progression. 34,37 The recent development of monoclonal antibodies to osteoclast bone-specific alkaline phosphatase allows more accurate assessment of bone formation. 39 Bone-specific alkaline phosphatase remains high and steady from Tanner 1 to 3, then decreases.…”

Section: Height Maturitymentioning

confidence: 99%

Correlates of the Peak Height Velocity in Girls With Idiopathic Scoliosis

Sanders

Browne²,

Cooney³

et al. 2006

Spine

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“…On a HOP-free diet the amount of HOP excreted in the urine over a 24-hour period has been shown to represent a reliable index of bone collagen metabolism (23). A relation between HOP and growth rate has also been shown to exist (29).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ascorbic Acid (Vitamin C) on the Epiphyseal Plate of Young Guinea Pigs Receiving Prednisolone

Liakakos¹,

Vlachos²,

Nl³

et al. 1981

Dev Pharmacol Ther

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The effect of excess ascorbic acid on the epiphyseal plate of young guinea pigs receiving prednisolone over a period of 28 days has been investigated. The results show that the structural and morphologic changes caused in the epiphyseal plate of the animals receiving prednisolone are prevented by the simultaneous administration of excess ascorbic acid. These data are consistent with the hypothesis that pharmacological doses of ascorbic acid given concurrently to children receiving prolonged treatment with corticosteroids may prevent suppression of growth in these children.

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Hydroxyproline Excretion and Height Velocity in Adolescent Boys

Cited by 19 publications

References 10 publications

Hydroxyproline excretion in various forms of growth failure.

Hydroxyproline excretion in various forms of growth failure.

Correlates of the Peak Height Velocity in Girls With Idiopathic Scoliosis

Effect of Ascorbic Acid (Vitamin C) on the Epiphyseal Plate of Young Guinea Pigs Receiving Prednisolone

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