SUMMARY 21 children with scoliosis were studied for a year during which time 24-hour urinary total hydroxyproline levels were estimated and anthropometric measurements were made on 4 occasions. The total hydroxyproline levels (using hydroxyproline centiles) and the uncorrected heights of the children were all normal. The sitting heights of the children were below average, but, although the sample was small, the findings indicate that the children's 'uncoiled' height would be greater than average.In scoliosis, progressive changes in the vertebral column may occur with growth. Its onset is generally noticed in infancy or adolescence.'-2 Measurable deterioration can occur during times of rapid increase in height. Because of the curvature of the spine in scoliotic children, the predicted normal height for age and stage of development is difficult to estimate. Significant differences in standing height between normal and scoliotic children were found by Willner,34 and Burwell et al.5 Burwell and coworkers found disproportion in upper limb length which was related to the convexity of the curvature.There is a close relationship between rate of growth and total hydroxyproline (THP) excretion. Fast growth rates are associated with high levels of urinary THP due to increased collagen turnover'69 Slow growth rates are associated with low THP levels. We studied THP excretion and anthropometric measurements of growth in a group of scoliotic children for a year. The purpose of the study was to compare the findings for these children with those for normal children'0 to see if there was any difference in THP levels and body size between the two groups.Material 21 children attending a scoliotic clinic as outpatients were studied. None of these children had had spinal surgery. 14 were girls with an age of 8 *2-16* 5 (mean