Hydroxyls on the B ring and gallic acyl are essential for catechins to restrain ADP-induced thrombosis

Pan, Yani; Feng, Xinyu; Zhou, Shanshan; Yang, Shiyan; Qiu, Pei; Gong, Shuying; Chu, Qiang; Chen, Ping

doi:10.1039/d2fo01232d

Cited by 4 publications

(5 citation statements)

References 51 publications

(58 reference statements)

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“…Green tea is a rich source of polyphenols, alkaloids, amino acids (AAs), vitamins, and other nutrients, with the effects of anti‐inflammation, bactericide, and cancer prevention (Pan et al., 2023; Puligundla et al., 2017; Su et al., 2023; Zhang et al., 2022). Studies have confirmed the promoting effects of green tea extracts (GTE) on oral health.…”

Section: Introductionmentioning

confidence: 99%

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Pan,

Lv,

Zhang

et al. 2023

Journal of Food Science

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Oral cavity contains the second largest microbial community in the human body. Due to the highly vascularized feature of mouth, oral microbes could directly access the bloodstream and affect the host healthy systemically. The imbalance of oral microbiota is closely related to various oral and systemic diseases. Green tea extracts (GTE) mainly contain tea polyphenols, alkaloids, amino acid, flavones, and so on, which equipped with excellent anti‐inflammatory activities. Previous studies have demonstrated the beneficial effects of GTE on oral health. However, most researches used in vitro models or focused on limited microorganisms. In this study, the regulatory effect of GTE on oral microbiome and the alleviative effect on oral inflammation in vivo were evaluated. The results showed that GTE could efficiently alleviate the inflammations of the tongue, cheek pouch, as well as throat. GTE effectively inhibited the activation of NF‐κB through the upregulation of the anti‐inflammatory cytokine interleukin (IL)‐10, consequently leading to reduced expression of pro‐inflammatory cytokines IL‐6 and tumor necrosis factor‐α. The indexes of spleen and thymus were also elevated by GTE in stomatitis mice. Moreover, GTE promoted the growth of probiotics Lactobacillus and Bacillus, inhibited the reproduction of pathogens Achromobacter, reversing the microbiota disorders in oral cavity. This study not only presents a novel approach for enhancing oral microecology but also facilitates the wider adoption of tea consumption.

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Section: Introductionmentioning

confidence: 99%

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Pan,

Lv,

Zhang

et al. 2023

Journal of Food Science

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“…First, tea and its bioactive components can prevent the formation of blood clots by inhibiting platelet aggregation induced by a variety of agonists, or by hindering thrombin proteolytic activity that triggers platelet activation. 4,26,27 Second, tea is rich in polyphenols, which are bioactive compounds with potential antioxidant and anti-inflammation effects that can improve endothelial function. 5,[28][29][30] Third, flavonoids, one the major polyphenols in tea, can promote blood flow by improving the bioavailability of endothelial nitric oxide.…”

Section: Discussionmentioning

confidence: 99%

“…Tea is one of the most widely consumed beverages worldwide, and it contains a high concentration of polyphenols, which have potential properties on antiobesity, antioxidant, anti-inflammation, and inhibiting platelet aggregation, 4,5 all of which are important risk factors for the development of VTE. [6][7][8] However, the association between tea consumption and the risk of VTE is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Tea Consumption, Milk or Sweeteners Addition, Genetic Variation in Caffeine Metabolism, and Incident Venous Thromboembolism

Xiang,

Liu,

Zhou

et al. 2024

Thromb Haemost

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Objective The association between tea consumption and venous thromboembolism (VTE) remains unknown. We aimed to evaluate the association between tea consumption with different additives (milk and/or sweeteners) and incident VTE, and the modifying effects of genetic variation in caffeine metabolism on the association. Methods A total of 190,189 participants with complete dietary information and free of VTE at baseline in the UK Biobank were included. The primary outcome was incident VTE, including incident deep vein thrombosis and pulmonary embolism. Results During a median follow-up of 12.1 years, 4,485 (2.4%) participants developed incident VTE. Compared with non-tea drinkers, tea drinkers who added neither milk nor sweeteners (hazard ratio [HR]: 0.85; 95% confidence interval [95% CI]: 0.76–0.94), only milk (HR: 0.86; 95% CI: 0.80–0.93), and both milk and sweeteners to their tea (HR: 0.90; 95% CI: 0.81–0.99) had a lower risk of VTE, while those who added only sweeteners to their tea did not (HR: 0.94; 95% CI: 0.75–1.17). Moreover, there was an L-shaped relationship between tea consumption and incident VTE among tea drinkers who added neither milk nor sweeteners, only milk, and both milk and sweeteners to their tea, respectively. However, a nonsignificant association was found among tea drinkers who added only sweeteners to their tea. Genetic variation in caffeine metabolism did not significantly modify the association (p-interaction = 0.659). Conclusion Drinking unsweetened tea, with or without added milk, was associated with a lower risk of VTE. However, there was no significant association between drinking tea with sweeteners and incident VTE.

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“…Furthermore, the hydroxyl substitution at position 3′ on ring B and glucosyl substitution at position 8 on ring A also improves the antithrombotic activity of flavones (Figure 2b) (Lee & Bae, 2015). For catechins, the three hydroxyls at positions 3′, 4′, and 5′ on ring B and the gallic acyl at position 3 on ring C are the specific functional groups that inhibit platelet aggregation, especially the gallic acyl (Figure 2c) (Pan et al, 2023).…”

Section: Natural Products For Thrombosis Treatmentmentioning

confidence: 99%

“…The major components of S. militorrhiza , salvianolic acids A, B, and C, exhibited high binding affinity to P2Y12, and salvianolic acids A and C can antagonize the activity of both P2Y1 and P2Y12 receptors (Liu, Gao, et al, 2018). Furthermore, epigallocatechin gallate and dehydrocorydaline also showed notable inhibitory effects on platelet aggregation by suppressing both P2Y1‐ and P2Y12‐mediated signaling (Pan et al, 2023; Tan et al, 2019).…”

Section: Molecular Mechanisms Of Antithrombotic Natural Productsmentioning

confidence: 99%

Therapeutic effects and molecular mechanisms of natural products in thrombosis

Yuan,

Zhong,

Wang

et al. 2024

Phytotherapy Research

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Thrombotic disorders, such as myocardial infarction and stroke, are the leading cause of death in the global population and have become a health problem worldwide. Drug therapy is one of the main antithrombotic strategies, but antithrombotic drugs are not completely safe, especially the risk of bleeding at therapeutic doses. Recently, natural products have received widespread interest due to their significant efficacy and high safety, and an increasing number of studies have demonstrated their antithrombotic activity. In this review, articles from databases, such as Web of Science, PubMed, and China National Knowledge Infrastructure, were filtered and the relevant information was extracted according to predefined criteria. As a result, more than 100 natural products with significant antithrombotic activity were identified, including flavonoids, phenylpropanoids, quinones, terpenoids, steroids, and alkaloids. These compounds exert antithrombotic effects by inhibiting platelet activation, suppressing the coagulation cascade, and promoting fibrinolysis. In addition, several natural products also inhibit thrombosis by regulating miRNA expression, anti‐inflammatory, and other pathways. This review systematically summarizes the natural products with antithrombotic activity, including their therapeutic effects, mechanisms, and clinical applications, aiming to provide a reference for the development of new antithrombotic drugs.

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Hydroxyls on the B ring and gallic acyl are essential for catechins to restrain ADP-induced thrombosis

Abstract: Platelet hyperactivation could lead to various cardiovascular and cerebrovascular diseases, while epidemiological analyses have found that long-term tea drinking could prevent and restrain cardiovascular diseases. Existing studies have shown that...

Cited by 4 publications

References 51 publications

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice

Tea Consumption, Milk or Sweeteners Addition, Genetic Variation in Caffeine Metabolism, and Incident Venous Thromboembolism

Therapeutic effects and molecular mechanisms of natural products in thrombosis

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