Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells

Reeves, James F.; Davies, Simon; Dodd, Nicholas J F; Jha, Awadhesh N.

doi:10.1016/j.mrfmmm.2007.12.010

Cited by 405 publications

(232 citation statements)

References 55 publications

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“…DNA damage classes one (Monday samples, p = 0.000; Friday samples, p = 0.000) and two (Monday samples, p = 0.000; Friday samples, p = 0.000) in the exposed group were higher than those observed in the control group, which showed a higher frequency of undamaged DNA (Table 4). None of the workers who [13,15,36,37]. However, the effects induced by the mixture of them are still controversial.…”

Section: Genotoxicity Assaysmentioning

confidence: 99%

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Cassini

Calloni

Bortolini

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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Objectives: Paints are complex mixtures of solvents and metals that can induce health damages in workers exposed to them. The aim of the present work was to evaluate possible oxidative and genotoxic effects in workers exposed to paints. Material and Methods: Peripheral blood and buccal cell samples were collected from 33 workers exposed to paints and 29 non-exposed workers (controls) during an ordinary working week (Monday morning and Friday evening). Oxidative markers were assessed using thiobarbituric acid assay, carbonylated proteins, superoxide dismutase and catalase activities. Hippuric acid and delta-aminolevulinic acid were determined as biomarkers of toluene and lead exposure, respectively. Genotoxicity was measured through comet assay and micronucleus (MN) frequencies. Results: The exposed group showed higher hippuric acid and delta-aminolevulinic acid levels (Friday samples) and lower superoxide dismutase activity (Monday samples) in relation to control group. DNA damage index (comet assay) was higher in the exposed group, both in Monday and Friday samples, compared to the control group. No differences were observed in frequency of micronuclei (MN) between the groups, either in lymphocytes or buccal cells. However, the exposed group presented an increase (Monday samples) in nuclear buds frequency in lymphocytes -a marker of gene amplificationas well as an increase in condensed chromatin in the buccal cells (Monday and Friday samples), suggesting induction of apoptosis. Furthermore, a decrease in the nuclear division index (Friday samples) was observed in the exposed group, indicating that paint exposure induces cytostatic effects in lymphocytes. Conclusion: The results suggest that individuals exposed to paints have increased levels of DNA damage.

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Section: Genotoxicity Assaysmentioning

confidence: 99%

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Cassini

Calloni

Bortolini

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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“…TiO 2 was classified as a carcinogenic nanoparticle used in cosmetics. Titanium dioxide (TiO 2 ) plays a role in the induction of apoptosis as well as oxidative stress [11][12][13]. One study indicated that Titanium dioxide TiO 2 can affect the mitochondria [14].…”

Section: Discussionmentioning

confidence: 99%

Calendula officinalis Protection Against Cytotoxicity Effects of Personal Care Products on HaCaT Human Skin Cells

Alnuqaydan¹,

Sanderson²

2016

J Clinic Toxicol

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“…Miller and coworkers [18] related that under low intensity UV, there is an increase of ROS in seawater with increasing TiO 2 -Np concentration. However, TiO 2 -Np promoted the production of ROS in P. subcapitata when exposed to UV, with or without a UV filter [38]; and in fish cells in the absence of UV [39]. In algae, an overall enhancement in the activities of antioxidant enzymes, such as catalase, following exposure to environmental stresses is evident.…”

Section: +mentioning

confidence: 97%

Nanoecotoxicological Effects of a Sunscreen Formulation based on Tio2 Nanoparticles on Microalgae from Guanabara Bay (Rio de Janeiro, Brazil)

Abe¹,

Cunha²,

Salomon³

et al. 2017

MOJPS

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The rise of nanotechnology has resulted in an increase in the use of nanoproducts, such as sunscreens based on nanoparticles of TiO 2 (TiO 2 -Np), which reach aquatic ecosystems through their manufacture, consumption and disposal. Studies indicate that TiO 2 -Np have an ecotoxicological potential, inactivating algae from the Anabaena, Microcystis and Melosira genera. Tetraselmis sp., abundant phytoplanktonic organisms of Guanabara Bay (Rio de Janeiro, Brazil), has been exposed to any discarded material released into this environment. In order to evaluate the effects of TiO 2 -Np on Tetraselmis sp., treatments with different doses of TiO 2 -Np were performed and their morphology, morphometry, surface charge, chlorophyll a rate and catalase production were analyzed. Under normal culture conditions, doses over 25 mg.L -1 caused intense precipitation, agglomeration and disruption of the cells, with remarkable variation of the zeta potential. No significant modification in the amount of chlorophyll a was observed, while the catalase production decreased only by 100 mg.L -1 of TiO 2 -Np. The results showed that TiO 2 -Np induced several effects in algae, highlighting their cell agglomeration. In conclusion, TiO 2 -Np provoked harmful effects in Tetraselmis sp., an important phytoplanktonic organism of Guanabara Bay (Rio de Janeiro, Brazil), and may disturb the dynamics of this ecosystem.

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Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells

Cited by 405 publications

References 55 publications

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Calendula officinalis Protection Against Cytotoxicity Effects of Personal Care Products on HaCaT Human Skin Cells

Nanoecotoxicological Effects of a Sunscreen Formulation based on Tio2 Nanoparticles on Microalgae from Guanabara Bay (Rio de Janeiro, Brazil)

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