Hydroxyethyl starch and modified fluid gelatin maintain plasma volume in a porcine model of septic shock with capillary leakage

Marx, Gernot; Meyer, M Cobas; Schürholz, Tobias; Vangerow, Burkhard; Gratz, K. F.; Hecker, Hartmut; Sümpelmann, Robert; Rueckoldt, H; Leuwer, Martin

doi:10.1007/s00134-002-1260-3

Cited by 81 publications

(61 citation statements)

References 31 publications

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“…For decades there has been a debate regarding whether one should use crystalloids or colloids [10][11][12][13], but there is also a debate regarding the efficacy of different colloids [14][15][16]. In contrast to colloids, crystalloids have small effects on coagulation, there is no risk of inducing allergic reactions, and they are inexpensive.…”

Section: Introductionmentioning

confidence: 99%

Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat

2006

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Objective: To compare the colloids 5% albumin, 4% gelatine, and 6% HES 130/0.4 with one another, and with saline, regarding their plasma expanding effects at increased permeability, and to compare the results with those from a previous study at normal permeability.Design: Prospective controlled randomised laboratory study.Setting: University research laboratory.Subjects: 48 adult male Sprague-Dawly rats.Interventions: Permeability was increased by an injection of 0.5 ml dextran 70 using the fact that dextran causes anaphylactic reaction in the rat. Plasma volume was determined ( 125 I albumin tracer technique) after anaesthesia, 1 h after the dextran injection (before infusion for 10-15 min of 20 ml/kg bw of each of the colloids or 80 ml/kg of saline), and 3 h later. Blood pressure, haematocrit, blood gases and electrolytes were measured. CVP was measured in 4 rats. Measurements and results:Plasma volume was 41.1±1.9 ml/kg at baseline (n=9), and 29.1±4.1 ml/kg (n=35) 1 h after the dextran injection (p<0.05). Three hours after infusion of the plasma expander, plasma volume had increased by 17.1±3.4 ml/kg in the albumin group, by 7.9±3.6 ml/kg in the gelatine group, by 7.4±4.4 ml/kg in the HES group, and by 12.2±3.1 ml/kg in the saline group. It was unchanged in a control group given no solution (n=7 for all groups) (Means ± SD). Conclusion:Albumin was a more effective plasma volume expander than gelatine or HES or saline (p<0.05), which were equally effective. All solutions showed a smaller plasma expanding effect than observed in a previous study with normal permeability.3

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Section: Introductionmentioning

confidence: 99%

Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat

2006

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“…This is met with several studies which denoted that colloids are more effective regarding their plasma expanding property than crystalloids. (9,21) Regarding 4% succinylated gelatin (the colloid of use in this study), and being a colloid of low average molecular weight, there was a believe that it escapes the capillary pores faster than that of medium and high molecular weight can do, hence, less plasma expanding effect (23) , however several studies have described gelatins and starches as equal plasma expanders both in: animal models (24)(25)(26) and human. (20,27) Moreover, in their study, Dileep et al (21) have described an equal duration of plasma expansion of both 4% succinylated gelatin (gelofusine) and 6% hydroxyethyl starch (Voluven) attributing this to the fact that hydroxyethyl starch is eliminated by the cleavage action of the serum amylase, which increased four times after infusion of hydroxyethyl starch as reported by Wilkes et al (28) The PaCO2 levels in this study were maintained by ventilation therefore, base excess (BE) and PH changes reflected any change in the non-respiratory (i.e.…”

Section: Discussion:-mentioning

confidence: 99%

Comparative Study Between Succinylated Gelatin (Gelofusine) Versus Ringer’s Acetate Regarding Safety and Efficacy in Adult Patients Undergoing Cardiac Surgery.

Abdelhady.¹,

Elhamamssy.²,

Ali³

et al. 2017

IJAR

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“…So it was worthy of studying the impacts of early albumin application on microvascular albumin leakage after major abdominal surgery. Currently, the main methods to reduce microvascular albumin leakage included: controlling infection, improving intravascular osmotic pressure through applying hypertonic saline or artificial colloid, applying inflammatory mediator antagonists, etc, among which HES 130/0.4 was one kind of novel HES with middle molecular weight, which could reduce vascular endothelial cell injuries and neutrophil-mediated tissue damages, increase intravascular osmotic pressure, reduce inflammatory responses, and maintain oxygenation of blood system, thus improving microcirculation and reducing microvascular leakage 18 , HES 130/0.4 also had certain "sealing" effects towards microvascular leakage 19,20 . Therefore, this study synergized albumin and HES to observe the impacts on mesenteric microvascular albumin leakage in the early stage after major abdominal surgery.…”

Section: ■ Discussionmentioning

confidence: 99%

Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits

Cen

et al. 2017

Acta Cir. Bras.

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Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits 1 3-Experimental SurgeryActa Cir Bras. 2017;32(2):108-115 AbstractPurpose: To investigate the impacts of albumin synergized with hydroxyethyl starch (HES) on early microvascular albumin leakage after major abdominal surgery in rabbits. Methods: Forty male Japanese rabbits were randomly divided into four groups: the control group, the saline group, the albumin group, and the Syn group (hydroxyethyl starch+albumin). The latter three groups were performed gastrectomy plus resection of pancreatic body and tail and splenectomy. The serum albumin concentration was detected before and 48h after surgery, and the conditions of mesenteric microvascular leakage in these 4 groups were observed under microscope 48 h after surgery to calculate the leakage rate. Results: Compared with the saline group, the albumin group and the Syn group exhibited significantly increased serum albumin concentrations 48h after surgery (P<0.05). The albumin leakage rate was the most obvious in the albumin group, followed by the saline group, while that in the Syn group was the minimal, and there existed significant differences among these groups (P<0.05). Conclusion:Simple administration of albumin in the early stage after major abdominal surgery could increase the albumin leakage, while the synergization of albumin and hydroxyethyl starch could reduce the albumin leakage.

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Hydroxyethyl starch and modified fluid gelatin maintain plasma volume in a porcine model of septic shock with capillary leakage

Cited by 81 publications

References 31 publications

Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat

Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat

Comparative Study Between Succinylated Gelatin (Gelofusine) Versus Ringer’s Acetate Regarding Safety and Efficacy in Adult Patients Undergoing Cardiac Surgery.

Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits

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