Hydroxychloroquine, cold urticaria, and the ice bucket challenge: A case report

Re-evaluating the Effectiveness of Hydroxychloroquine on Urticaria: A Systematic Review

“…Furthermore, both case reports by Iweala [16] and Merhi et al [17] as well as the case series by Eastman et al [19], all provide further low to moderate quality supporting evidence for the effectiveness of HCQ. Iweala et al [16] month of HCQ treatment.…”

“…Additionally, Eastman et al showed that 73.2% of patients in the study attained complete or partial response to HCQ, with a 2.3 month mean response time to treatment. The study by Merhi et al [17] was unique in that the investigators demonstrated that 200 mg of daily HCQ treatment resulted in resolution of the cold urticaria -a sub-classification of urticaria in which wheals appear on the skin soon after exposure to a cold stimulus, after 5 weeks. The results of this study are of great interest as it highlights the versatility of HCQ in the treatment of analogous urticarial pathologies and therefore warrants further investigation.…”

“…Details regarding the key characteristics of the 5 eligible studies are provided in Table 2. A total of 2 RCTs, 2 case reports, 2 retrospective cohort studies, and a single case series were retrieved [14][15][16][17][18][19][20]. Of the 81 participants who were randomised in the RCTs, 45 (56%) were assigned to the HCQ treatment group.…”