Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization

Abstract

HC is a potent COX-1/COX-2 inhibitor, ROS scavenger and inhibits platelet calcium signaling, TXB(2) production and aggregation. HC could be a potential therapeutic agent for prevention and treatment of atherosclerosis and other cardiovascular diseases through its anti-inflammatory and antiplatelet effects, without effects on haemostatic functions.

Baicalein inhibits agonist- and tumor cell-induced platelet aggregation while suppressing pulmonary tumor metastasis via cAMP-mediated VASP phosphorylation along with impaired MAPKs and PI3K-Akt activation

“…To evaluate the potential cytotoxicity of baicalein, we measured lactate dehydrogenase (LDH) leakage from platelets as previously described [50]. Baicalein was incubated at 37 8C for 6 min and then centrifuged at 350 Â g at room temperature for 3 min.…”

Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle

“…Among them, the most potent effect was found in the extract of Piper betle LINNE (Piperaceae) leaves. Although hydroxychavicol, 4-allylresorcinol, stigmast-4-en-3,6-dione and aristololactam A-II were reported to be present in the leaves, flowers or roots of P. betle [11,12], the XO inhibitory activity of those constituents have not been reported. In this paper, the screening of Piperaceous plants for XO inhibitory activity and the identification of the active principle from P. betle are reported.…”

Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties

“…Hydroxychavicol has also been shown to impede cell-cycle progression of prostate cancer and oral KB carcinoma cells (20)(21)(22). Several reports indicate hydroxychavicol as an antimutagenic agent (12,23) as well as an effective inhibitor of cyclooxygenase (COX), platelet calcium signaling, and thromboxane B2 production (21). Other studies suggest that hydroxychavicol also known as APC possesses antiulcerogenic activity (24) and has been shown to alleviate indomethacin-induced stomach ulceration leading to gastric cancer (25).…”

“…Hydroxychavicol, a phenolic compound quantitatively present at approximately 26% in betel leaves, has been shown to exert antiproliferative activity in prostate cancer (20). Hydroxychavicol has also been shown to impede cell-cycle progression of prostate cancer and oral KB carcinoma cells (20)(21)(22). Several reports indicate hydroxychavicol as an antimutagenic agent (12,23) as well as an effective inhibitor of cyclooxygenase (COX), platelet calcium signaling, and thromboxane B2 production (21).…”