Hydroxyapatite thin films synthesized by Pulsed Laser Deposition onto titanium mesh implants for cranioplasty applications

Duta, L.; Stan, George E.; Popescu, Andrei C.; Socol, G.; Miroiu, F.; Mihăilescu, I. N.; Ianculescu, Adelina; Poeată, I.; Chiriac, A.

doi:10.1117/12.2032338

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“…In general, the results of the studies included in this review, obtained using standardized radiography and microradiography [63], computed tomography [72,73,75], histomorphometry [65][66][67]69], and tomodensitometry [71], have confirmed the osseointegration process (pointing to an increase in the osseous density), along with a strong bone-implant connection and no inflammatory process of the soft tissues. The histological investigations, performed with various microscopy techniques [32,52,[63][64][65]67,70,[72][73][74][75], have indicated also new active bone formation and demonstrated no adverse inflammatory reactions or gaps around the sites of implantation or at the bone-implant interface, for any of the investigated structures.…”

Section: Discussionmentioning

confidence: 82%

“…All the information was grouped according to the applied small and large animal models, respectively (Table 3 It should be emphasized that because of the reduced number of in vivo studies on the PLD synthesis of CaP-based coatings, the use of a certain animal model as the most suitable one for the optimal assessment of metallic implants' osteoconduction has not been established yet. The reports on clinical trials (using human patients) are therefore scarce [71].…”

Section: Animal and Human Implant Modelsmentioning

confidence: 99%

“…In a pioneering contribution, Duta et al [71] used the tomodensitometry analysis to evidence the osteogenesis process of simple and functionalized Ti meshes implanted in human patients, at 3 and 6 months after surgery. After 3 months, no changes were detected for any of the investigated patients in terms of tissue density on Hounsfield (HU) scale.…”

Section: Tomodensitometrymentioning

confidence: 99%

“…The data presented in this review are available in Refs. [32,52,[63][64][65][66][67][68][69][70][71][72][73][74][75].…”

Section: Data Availability Statementmentioning

confidence: 99%

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In Vivo Assessment of Synthetic and Biological-Derived Calcium Phosphate-Based Coatings Fabricated by Pulsed Laser Deposition: A Review

Duta

2021

Coatings

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The aim of this review is to present the state-of-the art achievements reported in the last two decades in the field of pulsed laser deposition (PLD) of biocompatible calcium phosphate (CaP)-based coatings for medical implants, with an emphasis on their in vivo biological performances. There are studies in the dedicated literature on the in vivo testing of CaP-based coatings (especially hydroxyapatite, HA) synthesized by many physical vapor deposition methods, but only a few of them addressed the PLD technique. Therefore, a brief description of the PLD technique, along with some information on the currently used substrates for the synthesis of CaP-based structures, and a short presentation of the advantages of using various animal and human implant models will be provided. For an in-depth in vivo assessment of both synthetic and biological-derived CaP-based PLD coatings, a special attention will be dedicated to the results obtained by standardized and micro-radiographies, (micro) computed tomography and histomorphometry, tomodensitometry, histology, scanning and transmission electron microscopies, and mechanical testing. One main specific result of the in vivo analyzed studies is related to the demonstrated superior osseointegration characteristics of the metallic (generally Ti) implants functionalized with CaP-based coatings when compared to simple (control) Ti ones, which are considered as the “gold standard” for implantological applications. Thus, all such important in vivo outcomes were gathered, compiled and thoroughly discussed both to clearly understand the current status of this research domain, and to be able to advance perspectives of these synthetic and biological-derived CaP coatings for future clinical applications.

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