Hydroxyapatite reinforced inherent RGD containing silk fibroin composite scaffolds: Promising platform for bone tissue engineering

Behera, Sibaram; Naskar, Deboki; Sapru, Sunaina; Bhattacharjee, Promita; Dey, Tuli; Ghosh, Ananta K.; Mandal, Mahitosh; Kundu, Subhas C.

doi:10.1016/j.nano.2017.02.016

Cited by 54 publications

(28 citation statements)

References 64 publications

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“…Given the thixotropic properties and adjustable mechanical strength of the hydrogels, porosity and integrity of the films, and their simple, eco-friendly preparation methods, the presented systems hold remarkable potential for bone regeneration applications. Owing to its high mechanical strength and RGD integrin-binding motif, non-mulberry tropical tasar silkworm (Antheraea mylitta) fibroin has been considered to be a material able to achieve superior osteoblast adherence and improved bone regeneration process compared with the widely used B. mori SF [163]. Various composite scaffold architectures were fabricated including HA-coated, nanoHA-reinforced, and SF-HA-nanocomposite-reinforced scaffolds.…”

Section: Biomedical Applications Of Sf-based Materialsmentioning

confidence: 99%

Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

et al. 2019

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Since it was first discovered, thousands of years ago, silkworm silk has been known to be an abundant biopolymer with a vast range of attractive properties. The utilization of silk fibroin (SF), the main protein of silkworm silk, has not been limited to the textile industry but has been further extended to various high-tech application areas, including biomaterials for drug delivery systems and tissue engineering. The outstanding mechanical properties of SF, including its facile processability, superior biocompatibility, controllable biodegradation, and versatile functionalization have allowed its use for innovative applications. In this review, we describe the structure, composition, general properties, and structure-properties relationship of SF. In addition, the methods used for the fabrication and modification of various materials are briefly addressed. Lastly, recent applications of SF-based materials for small molecule drug delivery, biological drug delivery, gene therapy, wound healing, and bone regeneration are reviewed and our perspectives on future development of these favorable materials are also shared.

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Section: Biomedical Applications Of Sf-based Materialsmentioning

confidence: 99%

Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review

et al. 2019

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“…Nanobiocomposites tested and implanted for tissue regeneration include hydroxyapatite (HAp/collagen) to reproduce biocompatibility, composition, and mechanical properties of bones [46]. Other biopolymers, for example, chitosan [47], PLA [48], silk fibroin [49], and alginate [50] have also been studied in combination with HAp for the development of suitable bone regeneration scaffold. These implants mimic the surface roughness, porosity, and nanostructure of natural bones, as this facilitates the propagation of osteoblasts and helps in the regeneration of bones.…”

Section: Nanobiocomposites In Healthcare Sectormentioning

confidence: 99%

Bioinspired Nanocomposites: Functional Materials for Sustainable Greener Technologies

Qamar¹,

Asgher²,

Khalid³

2020

Renewable Energy - Resources, Challenges and Applications

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This chapter presents a broad overview of the current advancements in bioplastics and bioinspired nanocomposites with nanoscale reinforcements that are being applied for a broad range of applications, that is, biomedical, electronics, durable goods and packaging materials. The production of nanocomposites by completely and/or partially renewable and biodegradable materials has helped in a range of different applications. Several drawbacks of conventional materials such as hydrophilicity, low-heat deflection, poor conductivity, and barrier properties can be efficiently overcome using biohybrid nanomaterials. Nano-reinforcements in composite materials deliver remarkably improved properties such as decrease in hydrophilicity and increase in mechanical properties as compared with neat biopolymer, which fails to exhibit these properties on its own. This approach can be used for other natural polymers to induce desired functionalities. This chapter covers the recent trends in nano-functional materials, renewable materials that are being applied for the production of nanobiocomposites and their applications especially in biomedical and healthcare sectors, which are discussed in detail. This emerging concept will definitely enhance the scope of nanohybrid materials for sustainable products development with improved properties than previously applied synthetic polymer-based or natural polymer-based materials.

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“…34,35 The RGD immobilization into scaffolds has shown to enhance cell recognition. 36,37 Therefore, the use of cell-adhesive molecules (CAM) in conjunction with RGD has been employed to mimic cell interactions and to enhance cell adhesion. CAMs are grouped into several families, namely, immunoglobulins, cadherins, integrins, selectins and ECM proteins (Table 1).…”

Section: Cellular Recognition and Adhesion Peptidesmentioning

confidence: 99%