Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties

Kane, Robert J.; Weiss-Bilka, Holly E.; Meagher, Matthew J.; Liu, Yongxing; Gargac, Joshua A.; Niebur, Glen L.; Wagner, Diane R.; Roeder, Ryan K.

doi:10.1016/j.actbio.2015.01.031

Cited by 168 publications

(161 citation statements)

References 58 publications

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“…11,22,26 Recent reports indicate that the addition of one-dimensional HAP nanostructured materials such as HAP whiskers and nanowires can signicantly improve the mechanical properties and biological responses of the composite biomaterials. 11,18,22,27 More signicantly, the highly exible ultralong HAP nanowires (UHANWs) with lengths of several hundred micrometres were prepared by the calcium oleate precursor solvothermal method by this research group, [28][29][30] and exhibit a great potential in constructing different types of biomaterials with enhanced mechanical properties and improved biological responses. 18,27,31 In addition, the morphology of the UHANWs is similar to that of mineralized collagen brils in the natural bone.…”

Section: -10mentioning

confidence: 99%

“…[19][20][21] Consequently, the HAP/ collagen (HAP/Col) composite scaffolds can chemically and structurally mimic the natural bone, and have excellent bioactivity, biodegradability and osteoinductive activity. 11,13,22 So far, the biomimetic HAP/Col composite scaffolds with high porosity are typically fabricated via lyophilisation, which is benecial for cell inltration, neovascularization and new bone ingrowth.…”

Section: -10mentioning

confidence: 99%

“…22,35,36 The relative density (r a /r m ) was determined from the apparent density (r a ) and material density (r m ) of the freezedried porous nanocomposite. The material density of solid collagen and HAP was assumed to be 1.30 and 3.15 g mL À1 ,…”

Section: Porosity Of the As-prepared Porous Nanocompositementioning

confidence: 99%

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Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Sun

Chen

2018

RSC Adv.

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The synthetic bone grafts that mimic the composition and structure of human natural bone exhibit great potential for application in bone defect repair. In this study, a biomimetic porous nanocomposite consisting of ultralong hydroxyapatite nanowires (UHANWs) and collagen (Col) with 66.7 wt% UHANWs has been prepared by the freeze drying process and subsequent chemical crosslinking. Compared with the pure collagen as a control sample, the biomimetic UHANWs/Col porous nanocomposite exhibits significantly improved mechanical properties. More significantly, the rehydrated UHANWs/Col nanocomposite exhibits an excellent elastic behavior. Moreover, the biomimetic UHANWs/Col porous nanocomposite has a good degradable performance with a sustained release of Ca and P elements, and can promote the adhesion and spreading of mesenchymal stem cells. The in vivo evaluation reveals that the biomimetic UHANWs/Col porous nanocomposite can significantly enhance bone regeneration compared with the pure collagen sample. After 12 weeks implantation, the woven bone and lamellar bone are formed throughout the entire UHANWs/Col porous nanocomposite, and connect directly with the host bone to construct a relatively normal bone marrow cavity, leading to successful osteointegration and bone reconstruction. The as-prepared biomimetic UHANWs/Col porous nanocomposite is promising for applications in various fields such as bone defect repair.

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Section: -10mentioning

confidence: 99%

Section: -10mentioning

confidence: 99%

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Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Sun

Chen

2018

RSC Adv.

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“…40,41 Collagen-based materials that serve as analogs of organic components of bone matrix have previously been developed for bone regeneration. 10,42 It was hypothesized that the incorporation of MHMs or Zn-MHMs would improve the osteoinductive potential of the Coll scaffolds. Previous studies have demonstrated that hydroxyapatite could stimulate the osteogenesis of osteoblasts in vitro and induce in vivo bone formation.…”

Section: Yu Et Almentioning

confidence: 99%

“…6,7 The hydroxyapatite/collagen composite scaffolds mimicking the structure and composition of trabecular bone were extensively investigated, and they have been shown to have great potential in bone repair and regeneration. [8][9][10] The hydroxyapatite-collagen pairing naturally occurs in bone, whereby the collagen matrix provides strength and structural stability, whereas hydroxyapatite reinforces the organic matrix. 11 The organic matrix containing collagen and noncollagenous proteins plays an important role in mineralization, during which the organic matrix not only directs mineral deposition but also guides its growth.…”

mentioning

confidence: 99%

Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation

Sun

et al. 2017

IJN

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Biomaterials with high osteogenic activity are desirable for sufficient healing of bone defects resulting from trauma, tumor, infection, and congenital abnormalities. Synthetic materials mimicking the structure and composition of human trabecular bone are of considerable potential in bone augmentation. In the present study, a zinc (Zn)-doped mesoporous hydroxyapatite microspheres (Zn-MHMs)/collagen scaffold (Zn-MHMs/Coll) was developed through a lyophilization fabrication process and designed to mimic the trabecular bone. The Zn-MHMs were synthesized through a microwave-hydrothermal method by using creatine phosphate as an organic phosphorus source. Zn-MHMs that consist of hydroxyapatite nanosheets showed relatively uniform spherical morphology, mesoporous hollow structure, high specific surface area, and homogeneous Zn distribution. They were additionally investigated as a drug nanocarrier, which was efficient in drug delivery and presented a pH-responsive drug release behavior. Furthermore, they were incorporated into the collagen matrix to construct a biomimetic scaffold optimized for bone tissue regeneration. The Zn-MHMs/Coll scaffolds showed an interconnected pore structure in the range of 100–300 μm and a sustained release of Zn ions. More importantly, the Zn-MHMs/Coll scaffolds could enhance the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. Finally, the bone defect repair results of critical-sized femoral condyle defect rat model demonstrated that the Zn-MHMs/Coll scaffolds could enhance bone regeneration compared with the Coll or MHMs/Coll scaffolds. The results suggest that the biomimetic Zn-MHMs/Coll scaffolds may be of enormous potential in bone repair and regeneration.

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Principle Renewable Biopolymers and Their Biomedical Applications

Duru

Oğuz

Öztatlı

et al. 2017

Handbook of Composites From Renewable Materials

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Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties

Cited by 168 publications

References 58 publications

Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation

Principle Renewable Biopolymers and Their Biomedical Applications

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