Hydroxyapatite Particles—Directing the Cellular Activity in Bone Regeneration Processes: An Up-To-Date Review

Florea, Denisa Alexandra; Chircov, Cristina; Grumezescu, Alexandru Mihai

doi:10.3390/app10103483

Cited by 15 publications

(10 citation statements)

References 54 publications

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“…In addition, EDX analysis qualitatively confirmed HA deposition on the gyrospun PHA fibers following incubation in simulated body fluid (SBF) for 21 days (Figure S11). The formation of the hydroxyapatite crystals on the surface of an implant correlated with the in vivo bone bioactivity. , Thus, P(3HB) and P(3HB)/HA composite fibers demonstrated excellent potential as scaffolds to support and enhance bone formation.…”

Section: Resultsmentioning

confidence: 94%

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Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering

Basnett

Edirisinghe

Taylor

et al. 2021

ACS Appl. Mater. Interfaces

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Organ dysfunction is a major cause of morbidity and mortality. Transplantation is typically the only definitive cure, challenged by the lack of sufficient donor organs. Tissue engineering encompasses the development of biomaterial scaffolds to support cell attachment, proliferation, and differentiation, leading to tissue regeneration. For efficient clinical translation, the forming technology utilized must be suitable for mass production. Herein, uniaxial polyhydroxyalkanoate scaffolds manufactured by pressurized gyration, a hybrid scalable spinning technique, are successfully used in bone, nerve, and cardiovascular applications. Chorioallantoic membrane and in vivo studies provided evidence of vascularization, collagen deposition, and cellular invasion for bone tissue engineering. Highly efficient axonal outgrowth was observed in dorsal root ganglion-based 3D ex vivo models. Human induced pluripotent stem cell derived cardiomyocytes exhibited a mature cardiomyocyte phenotype with optimal calcium handling. This study confirms that engineered polyhydroxyalkanoate-based gyrospun fibers provide an exciting and unique toolbox for the development of scalable scaffolds for both hard and soft tissue regeneration.

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Section: Resultsmentioning

confidence: 94%

“…The formation of the hydroxyapatite crystals on the surface of an implant correlated with the in vivo bone bioactivity. 51,52 Thus, P(3HB) and P(3HB)/HA composite fibers demonstrated excellent potential as scaffolds to support and enhance bone formation.…”

Section: Resultsmentioning

confidence: 99%

Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering

Basnett

Edirisinghe

Taylor

et al. 2021

ACS Appl. Mater. Interfaces

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“…The resultant changes observed in surface morphology of HA were induced by stronger bonding of charged small molecules or peptides at (100) than (001) faces of HA comparable to chemical bonding. The bonding effect of small molecules in regulating the growth of HA crystals [46] also increased with the increase in the magnitude of the charge on small molecules, such as observed in the case of bone sialoprotein (BSP), osteopontin (OPN), dentin sialophosphoprotein (DSPP), dentin phosphoprotein (DPP), and amino acids [45,47]. The charge-dependent growth of HA also showed variation with the concentration of small molecules (50-80 mM).…”

Section: Bioactivity Of Scaffolds Having Small Molecules/proteins-mod...mentioning

confidence: 93%

Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity

et al. 2022

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Hydroxyapatite (HA) is a significant constituent of bones or teeth and is widely used as an artificial bone graft. It is often used to replace the lost bones or in reconstructing alveolar bones before dental implantation. HA with biological functions finds its importance in orthopedic surgery and dentistry to increase the local concentration of calcium ions, which activate the growth and differentiation of mesenchymal stem cells (MSC). To make relevant use of HA in bone transplantation, the surfaces of orthopedic and dental implants are frequently coated with nanosized hydroxyapatite (nHA), but its low dispersibility and tendency to form aggregates, the purpose of the surface modification of bone implants is defeated. To overcome these drawbacks and to improve the histocompatibility of bone implants or to use nHA in therapeutic applications of implants in the treatment of bone diseases, various studies suggested the attachment of biomolecules (growth factors) or drugs through chemical bonding at the surface of nHA. The growth factors or drugs bonded physically at the surface of nHA are mostly unstable and burst released immediately. Therefore, reported studies suggested that the surface of nHA needs to be modified through the chemical bonding of biologically active molecules at the surface of bone implants such as proteins, peptides, or naturally occurring polysaccharides to prevent the aggregation of nHA and to get homogenous dispersion of nHA in solution. The role of irradiation in producing bioactive and antibacterial nHA through morphological variations in surfaces of nHA is also summarized by considering internal structures and the formation of reactive oxygen species on irradiation. This mini-review aims to highlight the importance of small molecules such as proteins, peptides, drugs, and photocatalysts in surface property modification of nHA to achieve stable, bioactive, and antibacterial nHA to act as artificial bone implants (scaffolds) in combination with biodegradable polymers.

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“…In the reversal phase, which is a transient phase, bone resorption is inhibited, and pre-osteoblasts are recruited and subsequently differentiated to osteoblasts that will produce and mineralize the osteon. The osteoblasts undergo apoptosis or transform into lining cells or osteocytes [89,93]. The integrity of bone tissue is maintained through the delicate balance between resorption and formation processes.…”

Section: Essential Oils For Bone Repair and Regenerationmentioning

confidence: 99%

Essential Oils for Bone Repair and Regeneration—Mechanisms and Applications

et al. 2021

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Although bone possesses a remarkable capacity for self-remodeling and self-healing of small defects, the continuously increasing growth of bone diseases in the elderly population is becoming a significant burden, affecting individual life quality and society. Conventional treatment options involve surgical procedures for repair and reconstruction, local debridement, autografts or allografts, bone transport, Masquelet’s two-stage reconstructions, and vascularized bone transplants. However, as such approaches often lead to disruptions of bone-regeneration processes and microbial contaminations and are often inefficient, researchers focus on developing bone-regenerative strategies and identifying novel therapeutic agents that could aid the bone-healing process. In this regard, plant-derived biocompounds, especially essential oils (EOs), have received great scientific attention in recent years, owing to their antioxidant, anti-inflammatory, and antimicrobial effects. Current studies focus on either the direct application of EOs on bone tissue or the introduction of EOs as bioactive compounds in bone scaffolds or as coatings for bone implants. Some of the EOs investigated involve St. John’s wort, rosemary, thyme, ylang, white poplar, eucalyptus, lavender, and grape seed. In this context, the present paper aims to provide an overview of the main mechanisms involved in bone repair and regeneration and the potential of EOs to address and enhance these mechanisms.

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Hydroxyapatite Particles—Directing the Cellular Activity in Bone Regeneration Processes: An Up-To-Date Review

Cited by 15 publications

References 54 publications

Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering

Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering

Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity

Essential Oils for Bone Repair and Regeneration—Mechanisms and Applications

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