Hydroxyapatite nanorod and microsphere functionalized with bioactive lactoferrin as a new biomaterial for enhancement bone regeneration

Shi, Peipei; Wang, Qun; Yu, Chang Yeon; Fan, Fan; Li, Meng; Tu, Maolin; Lu, Weihong; Du, Ming

doi:10.1016/j.colsurfb.2017.04.042

Cited by 35 publications

(26 citation statements)

References 47 publications

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“…This could be achieved by modifications of the material with active compounds displaying the requested features. One possible solution are materials consisting of a mechanical stable structure (e.g., hydroxyapatite) [ 5 ] filled, coated or modified with polymers representing soft part, e.g., hydrogels [ 6 ], which can be altered with cells or bioactive molecules [ 7 ]. Many studies in the last years demonstrated that the critical point for bone tissue engineering is not the induction of bone growth but the supply of the implant with nutrients and oxygen, showing that vascularization of the implant and its surroundings is the main requirement [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

A New Bone Substitute Developed from 3D-Prints of Polylactide (PLA) Loaded with Collagen I: An In Vitro Study

Ritz

Gerke

Götz

et al. 2017

IJMS

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Although a lot of research has been performed, large segmental bone defects caused by trauma, infection, bone tumors or revision surgeries still represent big challenges for trauma surgeons. New and innovative bone substitutes are needed. Three-dimensional (3D) printing is a novel procedure to create 3D porous scaffolds that can be used for bone tissue engineering. In the present study, solid discs as well as porous cage-like 3D prints made of polylactide (PLA) are coated or filled with collagen, respectively, and tested for biocompatibility and endotoxin contamination. Microscopic analyses as well as proliferation assays were performed using various cell types on PLA discs. Stromal-derived factor (SDF-1) release from cages filled with collagen was analyzed and the effect on endothelial cells tested. This study confirms the biocompatibility of PLA and demonstrates an endotoxin contamination clearly below the FDA (Food and Drug Administration) limit. Cells of various cell types (osteoblasts, osteoblast-like cells, fibroblasts and endothelial cells) grow, spread and proliferate on PLA-printed discs. PLA cages loaded with SDF-1 collagen display a steady SDF-1 release, support cell growth of endothelial cells and induce neo-vessel formation. These results demonstrate the potential for PLA scaffolds printed with an inexpensive desktop printer in medical applications, for example, in bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

A New Bone Substitute Developed from 3D-Prints of Polylactide (PLA) Loaded with Collagen I: An In Vitro Study

Ritz

Gerke

Götz

et al. 2017

IJMS

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“…The maximum adsorption capacity of nano-hydroxyapatite is greater than that of micro- hydroxyapatites, due the larger surface area of nano-hydroxyapatite. They demonstrated that lactoferrin on hydroxyapatite surface could improve the biologic activity of hydroxyapatite [ 116 ]. Hydroxyapatite nanocrystals have been successfully used to fabricate bone scaffolds and implant coating materials and vehicles for drug targeting [ 117 ].…”

Section: The Multiple Properties Of Lactoferrinmentioning

confidence: 99%

Lactoferrin Functionalized Biomaterials: Tools for Prevention of Implant-Associated Infections

Páll

Roman

2020

Antibiotics

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Tissue engineering is one of the most important biotechnologies in the biomedical field. It requires the application of the principles of scientific engineering in order to design and build natural or synthetic biomaterials feasible for the maintenance of tissues and organs. Depending on the specific applications, the selection of the proper material remains a significant clinical concern. Implant-associated infection is one of the most severe complications in orthopedic implant surgeries. The treatment of these infections is difficult because the surface of the implant serves not only as a substrate for the formation of the biofilm, but also for the selection of multidrug-resistant bacterial strains. Therefore, a promising new approach for prevention of implant-related infection involves development of new implantable, non-antibiotic-based biomaterials. This review provides a brief overview of antimicrobial peptide-based biomaterials—especially those coated with lactoferrin.

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“…In the tissue engineering field, MIR spectroscopy has been used for characterizing biomaterials and scaffolds, and ECM. This includes constructs designed for articular cartilage 48–50 , bone 51, 52 , heart 53, 54 , skin 55, 56 , cornea 57, 58 , and bladder 59 . However, the use of MIR to evaluate ECM produced by cells on engineered tissue constructs has focused primarily on studies of articular cartilage and bone, which is what we focus on here.…”

Section: Applications Of Fourier Transform Infrared Spectroscopy Anmentioning

confidence: 99%

Vibrational spectroscopy and imaging: applications for tissue engineering

Querido

Falcon

Kandel

et al. 2017

Analyst

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Tissue engineering (TE) approaches strive to regenerate or replace an organ or tissue. The successful development and subsequent integration of a TE construct is contingent on a series of in vitro and in vivo events that result in an optimal construct for implantation. Current widely used methods for evaluation of constructs are incapable of providing an accurate compositional assessment without destruction of the construct. In this review, we discuss the contributions of vibrational spectroscopic assessment for evaluation of tissue engineered construct composition, both during development and post-implantation. Fourier transform infrared (FTIR) spectroscopy in the mid and near-infrared range, as well as Raman spectroscopy, are intrinsically label free, can be non-destructive, and provide specific information on the chemical composition of tissues. Overall, we examine the contribution that vibrational spectroscopy via fiber optics and imaging have to tissue engineering approaches.

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Hydroxyapatite nanorod and microsphere functionalized with bioactive lactoferrin as a new biomaterial for enhancement bone regeneration

Cited by 35 publications

References 47 publications

A New Bone Substitute Developed from 3D-Prints of Polylactide (PLA) Loaded with Collagen I: An In Vitro Study

A New Bone Substitute Developed from 3D-Prints of Polylactide (PLA) Loaded with Collagen I: An In Vitro Study

Lactoferrin Functionalized Biomaterials: Tools for Prevention of Implant-Associated Infections

Vibrational spectroscopy and imaging: applications for tissue engineering

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