Hydroxyapatite nanoceramics: Basic physical properties and biointerface modification

Aronov, D. A.; Карлов, А. В.; Rosenman, G.

doi:10.1016/j.jeurceramsoc.2007.02.121

Cited by 66 publications

(41 citation statements)

References 17 publications

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“…Calcium phosphate ceramics in the form of granules and porous scaffolds are widely used as bone substitutes in dentistry and orthopedics [1][2][3]. In order to improve mechanical properties and surgical handiness of bioceramics, a plasticizing agent e.g.…”

Section: Introductionmentioning

confidence: 99%

Biological properties of novel chitosan-based composites for medical application as bone substitute

Przekora

Ginalska

2014

Open Life Sciences

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Hydroxyapatite is the main inorganic component of bones and teeth. In order to improve mechanical properties and surgical handiness of bioceramics, a plasticizing agent e.g. polysaccharide can be added. Chitosan is a polysaccharide with biological properties that make it an ideal component of bioceramics-based composites for medical application as bone substitute. In this study, biocompatibility of two types of novel krill chitosan-based composites was evaluated. In vitro experiments were carried out using human foetal osteoblast cell line. Cytotoxicity, cell adhesion, and bone ALP activity tests were performed to assess biocompatibility of the composites. Osteoblast growth on composites was observed using confocal microscope. Our results demonstrated that fabricated novel composites are non-toxic, are favorable to cell adhesion and growth, and provoke increase in b-ALP activity with time, thus inducing osteoblast differentiation. Based on this data composites have promising clinical potential as a bone defect filler in regenerative medicine. It is worth emphasizing that our work resulted in fabrication of flexible and surgical handy, bone substitutes that possess absolute biocompatibility with structural and mechanical properties similar to trabecular bone.

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Section: Introductionmentioning

confidence: 99%

Biological properties of novel chitosan-based composites for medical application as bone substitute

Przekora

Ginalska

2014

Open Life Sciences

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“…However, the improvement of HA surface wettability by polarization did not affect structural transformation. In contrast, electron-induced surface energy modification such as photoluminescence and surface photovoltage spectroscopy was reported as an effective method of surface energy modification of HA nanoparticle coating 5 . The possible explanation for the improved surface wettability by polarization is the surface energy modification because of polar interaction energy with water.…”

Section: Discussionmentioning

confidence: 99%

“…The surface characteristics were reportedly affected by surface roughness, surface crystallinity 2 , the constituent elements at the surface, and the incorporation of ions such as carbonate or fluorine 3,4 . In addition, electron-induced surface energy modifications such as photoluminescence and surface photovoltage spectroscopy were also effective in the improvement of the surface characteristics 5 . The latter subject, stimulation from outside the cells, which includes electrical stimulation such as capacitive coupling, inductive coupling, and combined electromagnetic fields, affect osteoblast attachment, adhesion, and motility 5 .…”

Section: Introductionmentioning

confidence: 99%

Improved Wettability Increases Osteoblastic Adhesion on Hydroxyapatite

Nakamura

Nagai

Yamashita

2011

Phosphorus Research Bulletin

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Osteoblasts are susceptible to the surface characteristics of bioceramics and stimulation from outside the cells. The purpose of this study was to evaluate the effects of electrical polarization on surface characteristics and osteoblastic adhesion. The surface characteristics revealed that electrical polarization had no effect on surface roughness, crystallinity, and constituent elements. According to contact angle measurement, electrically polarized HA, which provides two kinds of surfaces, negatively charged HA (N-HA) and positively charged HA (P-HA), was even more hydrophilic than that of normal HA (HA). Morphological observations and quantitative analyses revealed that the typical adhered cells had a round shape on the HA but had a spindle or fan-like spreading configuration on the N-HA and the P-HA 1 h after seeding. After 3 h of cultivation, the rate of the number of spread cells and the size of focal adhesions on the HA increased and approached that of the N-HA and P-HA. However, the cell areas positively stained for actin, which indicates the degree of cell spreading, were distinctly larger on the N-HA and P-HA than that on the HA. The number of focal adhesions per cell was also less than that on the N-HA and P-HA.

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“…Extracellular stimuli such as capacitive coupling and combined electromagnetic fields affect cellular attachment, adhesion, and motility. 16) In the ceramic biomaterials fields, numerous studies of the interface between ceramic biomaterials and cells have revealed effects on osteoblast behaviours, including adhesion, proliferation, and differentiation. Control of osteoblast behaviour contributes to improved osteoconductivity.…”

Section: Surface Characteristics Of Polarized Bioceramicsmentioning

confidence: 99%

A study on tissue regeneration of the functionalized bioceramics

Nakamura

2014

J. Ceram. Soc. Japan

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Because of their excellent biocompatibility and osteoconductivity, ceramic biomaterials are clinically utilised as bone grafts for the reconstruction of injured bone tissues. Modification of the ceramic surface, leading to enhanced interaction with bone tissues, can improve the osteoconductive properties of bone grafts. Here, we explored the biophysical properties of bone tissue in order to develop a rationale for improved ceramic bone grafts. Material analyses revealed that the apatite minerals in bone tissues can store electrical energy generated by collagen fibrils in a piezoelectricity. Furthermore, we observed that bone, when polarized electrically by external voltage, depolarized by two mechanisms. Specifically, carbonate incorporation and electrical charges in bone minerals are important factors in bone piezoelectricity. These factors modulated osteogenic cell behaviours such as the osteoclastogenesis of peripheral mononuclear blood cells and the differentiation of mesenchymal stem cells into osteoblasts. Surface characteristics revealed that the electrical polarization increased the surface free energy and improved the surface wettability of the ceramic biomaterials. In addition, we applied the functionalized ceramic biomaterials to wound dressings and dental crowns. Composite materials, including polarized hydroxyapatite for wound dressing, enhanced epidermal recovery from full-thickness skin wounds. Surface modification by a combination of electrical polarization and chemical treatment improved bioactivity and durability of ceramics containing yttria-stabilized zirconia.

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Hydroxyapatite nanoceramics: Basic physical properties and biointerface modification

Cited by 66 publications

References 17 publications

Biological properties of novel chitosan-based composites for medical application as bone substitute

Biological properties of novel chitosan-based composites for medical application as bone substitute

Improved Wettability Increases Osteoblastic Adhesion on Hydroxyapatite

A study on tissue regeneration of the functionalized bioceramics

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