Hydroxyapatite nano bioceramics optimized 3D printed poly lactic acid scaffold for bone tissue engineering application

Mondal, Sudip; Nguyen, Thanh Phuoc; Pham, Van Hiep; Hoang, Giang; Manivasagan, Panchanathan; Kim, Myoung-Hwan; Nam, Seung Yun; Oh, Junghwan

doi:10.1016/j.ceramint.2019.10.057

Cited by 138 publications

(73 citation statements)

References 45 publications

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“…These efficacies of a scaffold are affected by the materials that make up the scaffold and its physical structures, such as exposed surface, pore size, pore distribution, and interconnectivity ( Table 3 ). These solid scaffolds are mainly porous foams or fibrous meshes fabricated from synthetic polymers, such as poly(glycolic acid) (PGA), poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and polycaprolactone (PCL), and naturally derived polymers, such as collagen, hyaluronic acid, fibrin, alginate, gelatine, silk, and chitosan [ 93 , 94 , 95 , 96 , 97 , 98 , 99 ].…”

Section: Applications Of Biomaterials In 3d Cell Culturementioning

confidence: 99%

Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

Park

Huh

Kang

2021

IJMS

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The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.

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Section: Applications Of Biomaterials In 3d Cell Culturementioning

confidence: 99%

Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

Park

Huh

Kang

2021

IJMS

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“…With potential application in osseointegration as films at the interface between a metallic implant and bone, porous films are preferred due to their more bioresorbable behavior under physiological conditions, with in this case the mechanical and thermal properties not being very important [8][9][10]. Higher mechanical properties can be obtained in the case of scaffolds obtained by 3D printing due to the large amount of polymer in the volume of the obtained material [44]. Also, in terms of mechanical properties, these can be significantly improved by the use of an additional polymer during the preparation of composite films, but with a much higher percent of HA.…”

Section: Plamentioning

confidence: 99%

Synthesis and Characterization of PLA-Micro-structured Hydroxyapatite Composite Films

Pandele

Constantinescu

Radu³

et al. 2020

Materials

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This article presents a facile synthesis method used to obtain new composite films based on polylactic acid and micro-structured hydroxyapatite particles. The composite films were synthesized starting from a polymeric solution in chloroform (12 wt.%) in which various concentrations of hydroxyapatite (1, 2, and 4 wt.% related to polymer) were homogenously dispersed using ultrasonication followed by solvent evaporation. The synthesized composite films were morphologically (through SEM and atomic force microscopy (AFM)) and structurally (through FT-IR and Raman spectroscopy) characterized. The thermal behavior of the composite films was also determined. The SEM and AFM analyses showed the presence of micro-structured hydroxyapatite particles in the film’s structure, as well as changes in the surface morphology. There was a significant decrease in the crystallinity of the composite films compared to the pure polymer, this being explained by a decrease in the arrangement of the polymer chains and a concurrent increase in the degree of their clutter. The presence of hydroxyapatite crystals did not have a significant influence on the degradation temperature of the composite film.

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“…Hence, PLA is widely known as a sustainable, non-toxic biocompatible, and biodegrading material. To date, PLA is often used for biomedical applications, such as bone tissue engineering[ 11 ], scaffolds[ 12 ], and implants fabrication. PLA-based implants benefit from the avoidance of stress shielding effects, which is a known disadvantage for metal implants.…”

Section: Introductionmentioning

confidence: 99%

“…The resulting scaffolds’ compressive properties and cell proliferation were observed. It was found that the optimal printing orientation was 90° as it produced the highest compressive strength (53 MPa), while no cell deaths were observed and all live cells have attached to the scaffold surface, thus ensuring the non-toxicity of the HAp-modified 3D printed PLA scaffolds[ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Powder Loading Effects on the Physicochemical and Mechanical Properties of 3D Printed Poly Lactic Acid/Hydroxyapatite Biocomposites

Custodio¹,

Broñola²,

Cayabyab³

et al. 2021

ijb

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This study presents the physicochemical and mechanical behavior of incorporating hydroxyapatite (HAp) with polylactic acid (PLA) matrix in 3D printed PLA/HAp composite materials. Effects of powder loading to the composition, crystallinity, morphology, and mechanical properties were observed. HAp was synthesized from locally sourced nanoprecipitated calcium carbonate and served as the filler for the PLA matrix. The 0, 5, 10, and 15 wt. % HAp biocomposite filaments were formed using a twin-screw extruder. The resulting filaments were 3D printed in an Ultimaker S5 machine utilizing a fused deposition modeling technology. Successful incorporation of HAp and PLA was observed using infrared spectroscopy and X-ray diffraction (XRD). The mechanical properties of pure PLA had improved on the incorporation of 15% HAp; from 32.7 to 47.3 MPa in terms of tensile strength; and 2.3 to 3.5 GPa for stiffness. Moreover, the preliminary in vitro bioactivity test of the 3D printed PLA/HAp biocomposite samples in simulated body fluid (SBF) indicated varying weight gains and the presence of apatite species’ XRD peaks. The HAp particles embedded in the PLA matrix acted as nucleation sites for the deposition of salts and apatite species from the SBF solution

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Hydroxyapatite nano bioceramics optimized 3D printed poly lactic acid scaffold for bone tissue engineering application

Cited by 138 publications

References 45 publications

Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

Synthesis and Characterization of PLA-Micro-structured Hydroxyapatite Composite Films

Powder Loading Effects on the Physicochemical and Mechanical Properties of 3D Printed Poly Lactic Acid/Hydroxyapatite Biocomposites

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